Cinema from Within Interrogating Black Identity and Representation In South African Cinema

The principal objective of this Film by Practice PhD is to explore, through both my identity as a black South African man and my practice as a writer/director/producer of film and television, how black identity and representation in South African cinema has developed from the colonial and Apartheid1 eras to the politically negotiated transition to democracy in 1994. Discourses on black/ blackness—with regards to cinema in both theory and practice— and their connection to race, class and gender are, of course, wide-ranging and often polemical. My research is primarily concerned with discourses on blackness as they relate to my experiences living and working as a black South African man during and after formal Apartheid

A Composite Index for Measuring Stock Market Inefficiency

Market inefficiency is a latent concept, and it is difficult to be measured by means of a single indicator. In this paper, following both the adaptive market hypothesis (AMH) and the fractal market hypothesis (FMH), we develop a new time-varying measure of stock market inefficiency. The proposed measure, called composite efficiency index (CEI), is estimated as the synthesis of the most common efficiency measures such as the returns' autocorrelation, liquidity, volatility, and a new measure based on the Hurst exponent, called the Hurst efficiency index (HEI). To empirically validate the indicator, we compare different European stock markets in terms of efficiency over time

Forage Accumulation and Quality of Three Contrasting Ecotypes of Tall Fescue (\u3ci\u3eSchedonorus arundinaceus\u3c/i\u3e) Managed under Frequent Defoliation

In the past, tall fescue ecotypes were compared under intermediate management defoliation frequency, but now has station, Argentina (-33 ° 56 \u27S, -60 ° 33\u27 W) in autumn 2016, on a typical Argiudoll soil. The treatments were cultivars representing three ecotypes of tall fescue: (i) - Mediterranean (cv. Flecha), (ii) - Intermediate (cv. Royal Q 100) and (iii) - Continental (cv. Lujan INTA). Each plot consisted of 7 rows 6.0 m long, 0.2 m apart (8.4m2 plot size) arranged in a randomized complete block design with 4 replicates. The first cut was done at the end of September when pastures reached \u3e 90 % of soil cover. The following six cuts were done when thermal time was 550°±50°C degree days (base temperature=4°C). The forage accumulation was determined by cutting with a mowing machine the central 5 m2 of each plot, at a height of 0.05 m. A sample (0.250 g) was taken to analyze in vitro dry matter digestibility (IVDIG), crude protein (CP), neutral detergent fiber (NDF) and NDF digestibility (NDFDIG). Mixed model was applied to consider ecotype and time effects. Ecotype*time interaction was significant for all variables (p\u3c 0.0001) except for forage accumulation. The values ranged between 491 and 2,625 kg DM ha-1 for forage accumulation, while IVDIG ranged between 57.2 and 68.7%, CP between 11.5 and 19.1%, NDF between 45.5 and 62.8% and NDFDIG between 26 and 65.3%. The Mediterranean ecotype produced less forage but in many cuts with higher CP. In many cuts, IVDIG was higher in the Continental ecotype associated with less leaf diseases

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry. We found a positive correlation between nuclear GLI1 expression and tumor grade in ductal carcinoma cases. Cytoplasmic Shh staining significantly correlated with a lower tumor grade. Next, the in vitro effects of two Hh signaling pathway inhibitors on breast cancer cell lines were evaluated using the Smoothened (SMO) antagonist GDC-0449 and the direct GLI1 inhibitor GANT-61. GDC-0449 and GANT-61 exhibited the following effects: a) inhibited breast cancer cell survival; b) induced apoptosis; c) inhibited Hh pathway activity by decreasing the mRNA expression levels of GLI1 and Ptch and inhibiting the nuclear translocation of GLI1; d) increased/decreased EGFR and ErbB2 protein expression, reduced p21- Ras and ERK1/ERK2 MAPK activities and inhibited AKT activation; and e) decreased the nuclear translocation of NF-κB. However, GANT-61 exerted these effects more effectively than GDC-0449. The in vivo antitumor activities of GDC-0449 and GANT- 61 were analyzed in BALB/c mice that were subcutaneously inoculated with mouse breast cancer (TUBO) cells. GDC-0449 and GANT-61 suppressed tumor growth of TUBO cells in BALB/c mice to different extents. These findings suggest that targeting the Hh pathway using antagonists that act downstream of SMO is a more efficient strategy than using antagonists that act upstream of SMO for interrupting Hh signaling in breast cancer

Characterization of a Be(p,xn) neutron source for fission yields measurements

We report on measurements performed at The Svedberg Laboratory (TSL) to characterize a proton-neutron converter for independent fission yield studies at the IGISOL-JYFLTRAP facility (Jyv\"askyl\"a, Finland). A 30 MeV proton beam impinged on a 5 mm water-cooled Beryllium target. Two independent experimental techniques have been used to measure the neutron spectrum: a Time of Flight (TOF) system used to estimate the high-energy contribution, and a Bonner Sphere Spectrometer able to provide precise results from thermal energies up to 20 MeV. An overlap between the energy regions covered by the two systems will permit a cross-check of the results from the different techniques. In this paper, the measurement and analysis techniques will be presented together with some preliminary results.Comment: 3 pages, 3 figures, also submitted as proceedings of the International Conference on Nuclear Data for Science and Technology 201

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

OBJECTIVE—Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception and targets of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pain in diabetes

Slowing and cooling molecules and neutral atoms by time-varying electric field gradients

A method of slowing, accelerating, cooling, and bunching molecules and neutral atoms using time-varying electric field gradients is demonstrated with cesium atoms in a fountain. The effects are measured and found to be in agreement with calculation. Time-varying electric field gradient slowing and cooling is applicable to atoms that have large dipole polarizabilities, including atoms that are not amenable to laser slowing and cooling, to Rydberg atoms, and to molecules, especially polar molecules with large electric dipole moments. The possible applications of this method include slowing and cooling thermal beams of atoms and molecules, launching cold atoms from a trap into a fountain, and measuring atomic dipole polarizabilities.Comment: 13 pages, 10 figures. Scheduled for publication in Nov. 1 Phys. Rev.

Power, norms and institutional change in the European Union: the protection of the free movement of goods

How do institutions of the European Union change? Using an institutionalist approach, this article highlights the interplay between power, cognitive limits, and the normative order that underpins institutional settings and assesses their impact upon the process of institutional change. Empirical evidence from recent attempts to reinforce the protection of the free movement of goods in the EU suggests that, under conditions of uncertainty, actors with ambiguous preferences assess attempts at institutional change on the basis of the historically defined normative order which holds a given institutional structure together. Hence, path dependent and incremental change occurs even when more ambitious and functionally superior proposals are on offer