Single-agent rituximab is an effective salvage therapy in pretreated patients with hairy cell leukemia

No abstract availabl

Italian real life experience with ibrutinib: Results of a large observational study on 77 relapsed/refractory mantle cell lymphoma

Although sometimes presenting as an indolent lymphoma, mantle cell lymphoma (MCL) is an aggressive disease, hardly curable with standard chemo-immunotherapy. Current approaches have greatly improved patients' outcomes, nevertheless the disease is still characterized by high relapse rates. Before approval by EMA, Italian patients with relapsed/refractory MCL were granted ibrutinib early access through a Named Patient Program (NPP). An observational, retrospective, multicenter study was conducted. Seventyseven heavily pretreated patients were enrolled. At the end of therapy there were 14 complete responses and 14 partial responses, leading to an overall response rate of 36.4%. At 40 months overall survival was 37.8% and progression free survival was 30%; disease free survival was 78.6% at 4 years: 11/14 patients are in continuous complete response with a median of 36 months of follow up. Hematological toxicities were manageable, and main extra-hematological toxicities were diarrhea (9.4%) and lung infections (9.0%). Overall, 4 (5.2%) atrial fibrillations and 3 (3.9%) hemorrhagic syndromes occurred. In conclusions, thrombocytopenia, diarrhea and lung infections are the relevant adverse events to be clinically focused on; regarding effectiveness, ibrutinib is confirmed to be a valid option for refractory/relapsed MCL also in a clinical setting mimicking the real world

L\u2019emergere del Political nei processi di rigenerazione urbana a Bologna: movimenti e spazi di dissenso

Negli ultimi decenni, nel quadro della teoria post-politica, si \ue8 sviluppato un ampio dibattito sui concetti di Politics e Political, discutendone la loro natura divergente e l\u2019epistemologia conflittuale e avanzando una maggiore concettualizzazione del Political, dei relativi spazi e attori. Nel contesto della citt\ue0 neoliberale, i processi di rigenerazione urbana si possono ricondurre alla nozione di Politics, in riferimento alla loro natura tecnocratica e all\u2019utilizzo di strumenti partecipatori di governance volti alla deliberazione del consenso. Nonostante l\u2019apparente carattere inclusivo, le pratiche di rigenerazione tendono a marginalizzare il dissenso e perci\uf2 sono messe in discussione da esperienze sociali che possono ricondursi all\u2019ambito del Political. Nell\u2019ambito del dibattito della teoria post-politica, l\u2019articolo mira a riflettere sulle politiche di rigenerazione urbana promosse nella citt\ue0 di Bologna e ad analizzare l\u2019emergere del Political focalizzandosi su due movimenti sociali: il collettivo Labas e il movimento socio-ambientale Rigenerazione NO Speculazione. Se Labas \ue8 emerso come spazio urbano radicato nella comunit\ue0 locale volto a promuovere una visione alternativa di citt\ue0 attraverso la difesa e valorizzazione dello spazio pubblico, Rigenerazione NO Speculazione ha rivendicato la democratizzazone dei processi di rigenerazione urbana promuovendo istanze quali la giustizia spaziale, ambientale e climatica. L\u2019analisi di pratiche, posizioni, spazi e visioni dei due movimenti urbani ci permette di riflettere sulla natura eterogenea del Political in contrapposizione alle politiche urbane contemporane

Politics, conflict and “political” community: The case of Bologna

In the framework of critical geographies post-politics theory has discussed the depoliticization of politics, technocratic urban governance and the nature of the political as a heterogeneous radical space of disagreement and solidarity. However, the concept of community in relation to post-politics and, in particular, the political requires further exploration. Building on Roberto Esposito's conceptualization of communitas, our article contributes to the theoretical reflection on political community by exploring the evolution of conflicting relations between institutional politics and urban struggles in Bologna, Italy. The findings discuss the fragmentation of the local political community due to the neutralization of dissent together with divergent and exclusive political stances unable to advance a shared front to challenge political mechanisms. In relation to this fragmentation, we reflect on the nature of socio-environmental struggles as a possible move to build a political community to advance new ontologies in the direction of environmental and climate justice

Gastric MALT Lymphoma in a Sleeve Gastrectomy Specimen: Case Report and Literature Review

In the last years, there has been a rise in the use of sleeve gastrectomy (SG) as primary surgical option in the management of morbid obesity. As result, SG specimens (SGSs) are commonly received for histological examination. In the majority of cases, histological findings are no specific modifications and/or benign inflammatory diseases, with a very low percentage of premalignant conditions, benign and/or malignant tumors, including exceptional reported cases of lymphomas. In this study, we present a case of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma incidentally diagnosed on an SGS, with a brief literature review of analogous cases in this particular setting of patients

PD-1 blockade as bridge to allogenic stem cell transplantation in relapsed/refractory Hodgkin lymphoma patients: a retrospective single center case series

N

90

No abstract available