Nutrition and dementia: Evidence for preventive approaches?

In recent years, the possibility of favorably influencing the cognitive trajectory through promotion of lifestyle modifications has been increasingly investigated. In particular, the relationship between nutritional habits and cognitive health has attracted special attention. The present review is designed to retrieve and discuss recent evidence (published over the last 3 years) coming from randomized controlled trials (RCTs) investigating the efficacy of nutritional interventions aimed at improving cognitive functioning and/or preventing cognitive decline in non-demented older individuals. A systematic review of literature was conducted, leading to the identification of 11 studies of interest. Overall, most of the nutritional interventions tested by the selected RCTs were found to produce statistically significant cognitive benefits (defined as improved neuropsychological test scores). Nevertheless, the clinical meaningfulness of such findings was not adequately discussed and appears controversial. In parallel, only 2 studies investigated between-group differences concerning incident dementia and mild cognitive impairment cases, reporting conflicting results. Results of the present review suggest that several dietary patterns and nutritional components may constitute promising strategies in postponing, slowing, and preventing cognitive decline. However, supporting evidence is overall weak and further studies are needed

The unique case of the AGN core of M87: a misaligned low power blazar?

M87 hosts one of the closest jetted active galactic nucleus (AGN) to Earth. Thanks to its vicinity and to the large mass of is central black hole, M87 is the only source in which the jet can be directly imaged down to near-event horizon scales with radio very large baseline interferometry (VLBI). This property makes M87 a unique source to isolate and study jet launching, acceleration and collimation. In this paper we employ a multi-zone model designed as a parametrisation of general relativistic magneto-hydrodynamics (GRMHD); for the first time we reproduce the jet's observed shape and multi-wavelength spectral energy distribution (SED) simultaneously. We find strong constraints on key physical parameters of the jet, such as the location of particle acceleration and the kinetic power. However, we under-predict the (unresolved) {\gamma}-ray flux of the source, implying that the high-energy emission does not originate in the magnetically-dominated inner jet regions. Our results have important implications both for comparisons of GRMHD simulations with observations, and for unified models of AGN classes.Comment: 12 pages, 7 figures, accepted for publication on MNRAS, comments are welcom

The dynamics of the β-propeller domain in Kelch protein KLHL40 changes upon nemaline myopathy-associated mutation

Evolutionarily widespread, functionally and structurally diverse and still largely unexplored, Kelch proteins, characterized by the presence of a conserved C-terminal β-propeller, are implicated in a number of diverse fundamental biological functions, including cytoskeletal arrangement, regulation of cell morphology and organization, and protein degradation. Mutations in the genes encoding for Kelch superfamily members are being discovered as the cause of several neuromuscular diseases and cancer. The E528K mutation in Kelch protein KLHL40, which regulates skeletal muscle myogenesis, has been identified as a frequent cause of severe autosomal-recessive nemaline myopathy (NM). We use all-atom molecular dynamics simulations to characterize the dynamic behaviour of the β-propeller of the wild-type protein and identify correlated motions underlying the in vivo functionality. We also modelled the NM-associated mutation and we found that it does not lead to dramatic disruption of the β-propeller architecture; yet, residue 528 is a hub in the correlated motions of the domain, and mutation-induced local structural alterations are propagated to the whole protein, affecting its dynamics and physicochemical properties, which are fundamental for in vivo interaction with partners. Our results indicate that rational design of drugs can be envisioned as a strategy for restoring the internal network of communication and resetting KLHL40 to its physiological state

Venturi mask is the pioneer of High-Flow Oxygen Therapy Concepts

Oxygen therapy should be carefully considered and monitored because, as any other medications, it can cause harm to patients, if used inappropriately. This paper focus on the distinction between low-flow and high-flow oxygen therapy. A discussion about Venturi system for oxygen administration is carried on, given that some authors include it in the low-flow devices group despite its characteristics to deliver high flow therapy

Role of intra-band transitions in photo-carrier generation

We theoretically investigate the role of intra-band transitions in laser-induced carrier-generation for different photon energy regimes: (i) strongly off-resonant, (ii) multi-photon resonant, and (iii) resonant conditions. Based on the analysis for the strongly off-resonant and multi-photon resonant cases, we find that intra-band transitions strongly enhance photo-carrier generation in both multi-photon absorption and tunneling excitation regimes, and thus, they are indispensable for describing the nonlinear photo-carrier generation processes. Furthermore, we find that intra-band transitions enhance photo-carrier generation even in the resonant condition, opening additional multi-photon excitation channels once the laser irradiation becomes sufficiently strong. The above findings suggest a potential for efficient control of photo-carrier generation via multi-color laser pulses through optimization of the contributions from intra-band transitions

The peculiar variable X-ray spectrum of the active galactic nucleus PKS 2005-489

PKS 2005-489 is a well-known, bright southern BL Lac object that has been detected up to TeV energies. In a low-flux state it exhibits the expected multiwavelength double-peaked spectrum in the radio -- $\gamma$-ray band. The high-flux state shows extreme flux variations in the X-ray band with a hardening as well as a peculiar curved feature in the spectrum. Thus far, PKS 2005-489 is the only source to exhibit such a feature. To study the X-ray variability further, we obtained the first hard X-ray spectrum of the source with NuSTAR. We compare quasi-simultaneous radio, optical, UV, soft and hard X-ray, and $\gamma$-ray data of PKS 2005-489 to archival data in order to study its broadband behavior. We find a very consistent quiet state in the SED, with little variation in spectral shape or flux between the 2012 and 2020 data. A possible explanation for the peculiar X-ray spectrum in the flaring state is an additional component in the jet, possibly accelerated via magnetic reconnection, that is not co-spatial to the low-flux state emission region

The RSC chromatin-remodeling complex influences mitotic exit and adaptation to the spindle assembly checkpoint by controlling the Cdc14 phosphatase

Rsc2 promotes Cdc14 release from the nucleolus to free cells from mitotic arrest

Time-frequency mapping of two-colour photoemission driven by harmonic radiation

The use of few-femtosecond, extreme ultraviolet (XUV) pulses, produced by high-order harmonic generation, in combination with few-femtosecond infrared (IR) pulses in pump-probe experiments has great potential to disclose ultrafast dynamics in molecules, nanostructures and solids. A crucial prerequisite is a reliable characterization of the temporal properties of the XUV and IR pulses. Several techniques have been developed. The majority of them applies phase reconstruction algorithms to a photoelectron spectrogram obtained by ionizing an atomic target in a pump-probe fashion. If the ionizing radiation is a single harmonic, all the information is encoded in a two-color two-photon signal called sideband (SB). In this work, we present a simplified model to interpret the time-frequency mapping of the SB signal and we show that the temporal dispersion of the pulses directly maps onto the shape of its spectrogram. Finally, we derive an analytical solution, which allows us to propose a novel procedure to estimate the second-order dispersion of the XUV and IR pulses in real time and with no need for iterative algorithms

CADASIL or MS? Consider “Red Flags” but Avoid a Misdiagnosis: Case Series of a Concomitant Diagnosis

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic autosome-dominant disease with chronic clinical course. Rarely, CADASIL may present with atypical relapsing-remitting manifestations, cerebral and spinal white matter lesions, mimicking inflammatory CNS disease as multiple sclerosis (MS). The rarely co-occurrence of MS and CADASIL may represent a hard challenging diagnosis even for an expert neurologist. Here, we present a case series of two patients with CADASIL showing MRI pattern overlapping MS. They were the only case of co-occurrence of CADASIL and MS in their own family. Both patients were treated with anti-inflammatory and anti-platelet drugs, mostly with good response. Pathogenic hypothesis highlights that genetic events, related to monogenic disease, may expose CNS antigens with a consequent self-immune attack. In CADASIL, the function of Notch3 receptor showed a consistent interplay with immune system activity. Indeed, certain mutations of Notch3 receptor show abnormal upregulation of specific pro-inflammatory patterns. However, even if it is not possible to determinate if the proinflammatory activity may be promoted by pathogenic mutations in Notch3, the "apparent" difference between MS and “inflammatory CADASIL” could be considered more semantic than etiologic