1,805 research outputs found
Patient-reported outcome measures, complication rates, and re-revision rates are not associated with the indication for revision total hip arthroplasty : a prospective evaluation of 647 consecutive patients
Barrier effect of hydrolyzed collagen: characterization and chemical-physical behavior
This thesis concerns hydrolyzed collagen, also called gelatin, widely used in pharmaceutical
industry both for its nutritional properties, in order to correct the deficiency arising from its
insufficient dietary intake, and for its protective action towards aggressive agents, mainly
used by topical route. Chemical composition, molecular structure and medical uses of
collagen are described together with its metabolism in human body, with particular reference
to hydrolyzed collagen.
With the above premise, the research was focused on:
a) the chemical-physical characterization of the barrier effect of collagen, measuring it
towards the erosive action of hydrochloric acid;
b) the influence of the aminoacidic composition and degree of hydrolysis on the barrier
effect.
c) the effectiveness of hydrolyzed collagen and different antacidsin controlling acidity levels
in vitro.
On the basis of these experimental results a food supplement, based on hydrolyzed collagen
and tricalcium phosphate, was developed. Its efficacy and safety were tested by a clinical
trial in patients affected from functional dyspepsia.
These preliminary findings require validation with additional data from further
investigations, including a double-blinded and randomized clinical trial. It is of note,
however, that the present study deals with magnitudes in the order of 100 per cent. Their
statistical confrontation provides the so called âfactualâ evidence, which is different from
the âexperimentalâ one. Moreover, the present study involved patients that did not respond
to current treatments. Therefore, this food supplement should be evaluated from the point of
view of âexperimental therapyâ, rather than âexperimental researchâ
Effects of olive and pomegranate by-products on human microbiota : a study using the SHIME (R) in vitro simulator
Two by-products containing phenols and polysaccharides, a "pate" (OP) from the extra virgin olive oil milling process and a decoction of pomegranate mesocarp (PM), were investigated for their effects on human microbiota using the SHIME (R) system. The ability of these products to modulate the microbial community was studied simulating a daily intake for nine days. Microbial functionality, investigated in terms of short chain fatty acids (SCFA) and NH4+, was stable during the treatment. A significant increase in Lactobacillaceae and Bifidobacteriaceae at nine days was induced by OP mainly in the proximal tract. Polyphenol metabolism indicated the formation of tyrosol from OP mainly in the distal tract, while urolithins C and A were produced from PM, identifying the human donor as a metabotype A. The results confirm the SHIME (R) system as a suitable in vitro tool to preliminarily investigate interactions between complex botanicals and human microbiota before undertaking more challenging human studies
Numerical Analysis of a Low NOx Partially Premixed Burner for Industrial Gas Turbine Applications
Abstract A numerical analysis of a low NOx partially premixed burner for industrial gas turbine applications is presented. In the first part the mixing inside a double annular counter-rotating swirl nozzle where the fuel is injected in a transverse jet configuration is studied. Standard k â â model and Two variable Schmidt number models were assessed in order to find a reliable configuration able to fit the available experimental profiles. Resulting profiles are used to perform reactive simulations of the experimental test rig, where NOx, CO measurement were available Results are compared in terms of NOx concentration at the outlet with experimental data
Ca-Lignosulphonate and sclerotial viability of Sclerotinia sclerotiorum
Lignosulphonates, low cost by-products of the pulping process, have shown suppressive effects against some diseases caused by soil-borne pathogens. In this study, the effect of 1.5% v/v calcium lignosulphonate (Ca-Ls) amendment to two commercial potting mixes (peat + coconut fibres; PC; and municipal compost + peat + pumice; MCPP) on the viability of Sclerotinia sclerotiorum sclerotia was investigated. Sclerotia were buried in the Ca-Ls amended substrates for 30 days. Non-amended PC and MCPP, sterile sand and sterile PC with and without Ca-Ls were used as controls. The viability of sclerotia recovered from PC and MCPP amended with Ca-Ls was reduced by 50 and 42% respectively compared to control treatments. Ca-Ls amendment decreased sclerotial viability by enhancing the activity of the indigenous mycoparasitic fungi, Fusarium oxysporum, Mucor spp. and Trichoderma spp. The biocontrol ability of Ca-Ls against sclerotia was due to the stimulation of microbial activity and is, therefore, strictly dependent on the microbial composition of the substrate
Total Knee Arthroplasty in Haemophilia: Long-Term Results and Survival Rate of a Modern Knee Implant with an Oxidized Zirconium Femoral Component
Arthroscopic confirmation of femoral button deployment avoids post-operative X-ray in ACL reconstruction
Left ventricular cavity obliteration during dobutamine stress echocardiography in diabetic patients
Precision and accuracy of robot-assisted technology with simplified express femoral workflow in measuring leg length and offset in total hip arthroplasty
Cortico-Cortical Connectivity between Right Parietal and Bilateral Primary Motor Cortices during Imagined and Observed Actions: A Combined TMS/tDCS Study
Previous transcranial magnetic stimulation (TMS) studies showed functional connections between the parietal cortex (PC) and the primary motor cortex (M1) during tasks of different reaching-to-grasp movements. Here, we tested whether the same network is involved in cognitive processes such as imagined or observed actions. Single pulse TMS of the right and left M1 during rest and during a motor imagery and an action observation task (i.e., an indexâthumb pinch grip in both cases) was used to measure corticospinal excitability changes before and after conditioning of the right PC by 10âmin of cathodal, anodal, or sham transcranial direct current stimulation (tDCS). Corticospinal excitability was indexed by the size of motor-evoked potentials (MEPs) from the contralateral first dorsal interosseous (FDI; target) and abductor digiti minimi muscle (control) muscles. Results showed selective ipsilateral effects on the M1 excitability, exclusively for motor imagery processes: anodal tDCS enhanced the MEPsâ size from the FDI muscle, whereas cathodal tDCS decreased it. Only cathodal tDCS impacted corticospinal facilitation induced by action observation. Sham stimulation was always uneffective. These results suggest that motor imagery, differently from action observation, is sustained by a strictly ipsilateral parieto-motor cortex circuits. Results might have implication for neuromodulatory rehabilitative purposes
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