1,064 research outputs found
Correlator Bank Detection of GW chirps. False-Alarm Probability, Template Density and Thresholds: Behind and Beyond the Minimal-Match Issue
The general problem of computing the false-alarm rate vs. detection-threshold
relationship for a bank of correlators is addressed, in the context of
maximum-likelihood detection of gravitational waves, with specific reference to
chirps from coalescing binary systems. Accurate (lower-bound) approximants for
the cumulative distribution of the whole-bank supremum are deduced from a class
of Bonferroni-type inequalities. The asymptotic properties of the cumulative
distribution are obtained, in the limit where the number of correlators goes to
infinity. The validity of numerical simulations made on small-size banks is
extended to banks of any size, via a gaussian-correlation inequality. The
result is used to estimate the optimum template density, yielding the best
tradeoff between computational cost and detection efficiency, in terms of
undetected potentially observable sources at a prescribed false-alarm level,
for the simplest case of Newtonian chirps.Comment: submitted to Phys. Rev.
Role of microRNAs (miRNAs) in the pathophysiology of Diabetes mellitus
© 2017 EDIZIONI MINERVA MEDICA. Diabetes mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of β cells within the pancreas. This disease becomes the leading cause of death, so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters. Here in this review role of miRNA is being illustrated as it plays a crucial role in the pathogenesis, progression, and fate of beta cells of pancreas regulating the insulin secretion. Here in this review, we try to include the effects and pathophysiology of various miRNA in diabetes mellitus and on the various sites of the human body
Testing the Mutually Enhanced Magicity Effect in Nuclear Incompressibility via the Giant Monopole Resonance in the Pb Isotopes
Using inelastic -scattering at extremely forward angles, including
, the strength distributions of the isoscalar giant monopole resonance
(ISGMR) have been measured in the Pb isotopes in order to
examine the proposed mutually enhanced magicity (MEM) effect on the nuclear
incompressibility. The MEM effect had been suggested as a likely explanation of
the "softness" of nuclear incompressibility observed in the ISGMR measurements
in the Sn and Cd isotopes. Our experimental results rule out any manifestation
of the MEM effect in nuclear incompressibility and leave the question of the
softness of the open-shell nuclei unresolved still.Comment: Accepted for publication in Physics Letters B. Very minor changes in
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The effects of spatial constraints on the evolution of weighted complex networks
Motivated by the empirical analysis of the air transportation system, we
define a network model that includes geographical attributes along with
topological and weight (traffic) properties. The introduction of geographical
attributes is made by constraining the network in real space. Interestingly,
the inclusion of geometrical features induces non-trivial correlations between
the weights, the connectivity pattern and the actual spatial distances of
vertices. The model also recovers the emergence of anomalous fluctuations in
the betweenness-degree correlation function as first observed by Guimer\`a and
Amaral [Eur. Phys. J. B {\bf 38}, 381 (2004)]. The presented results suggest
that the interplay between weight dynamics and spatial constraints is a key
ingredient in order to understand the formation of real-world weighted
networks
14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells
<p>Abstract</p> <p>Background</p> <p>The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence major emphasis is being laid on identification of novel molecular targets and development of multi-targeted therapies. 14-3-3 zeta, a multifunctional phospho-serine/phospho-threonine binding protein, is emerging as an effector of pro-survival signaling by binding to several proteins involved in apoptosis (Bad, FKHRL1 and ASK1) and may serve as an appropriate target for head and neck cancer therapy. Herein, we determined effect of guggulsterone (GS), a farnesoid X receptor antagonist, on 14-3-3 zeta associated molecular pathways for abrogation of apoptosis in head and neck cancer cells.</p> <p>Methods</p> <p>Head and neck cancer cells were treated with guggulsterone (GS). Effect of GS-treatment was evaluated using cell viability (MTT) assay and apoptosis was verified by annexin V, DNA fragmentation and M30 CytoDeath antibody assay. Mechanism of GS-induced apoptosis was determined by western blotting and co-IP assays using specific antibodies.</p> <p>Results</p> <p>Using in vitro models of head and neck cancer, we showed 14-3-3 zeta as a key player regulating apoptosis in GS treated SCC4 cells. Treatment with GS releases BAD from the inhibitory action of 14-3-3 zeta in proliferating HNSCC cells by activating protein phosphatase 2A (PP2A). These events initiate the intrinsic mitochondrial pathway of apoptosis, as revealed by increased levels of cytochrome c in cytoplasmic extracts of GS-treated SCC4 cells. In addition, GS treatment significantly reduced the expression of anti-apoptotic proteins, Bcl-2, xIAP, Mcl1, survivin, cyclin D1 and c-myc, thus committing cells to apoptosis. These events were followed by activation of caspase 9, caspase 8 and caspase 3 leading to cleavage of its downstream target, poly-ADP-ribose phosphate (PARP).</p> <p>Conclusion</p> <p>GS targets 14-3-3 zeta associated cellular pathways for reducing proliferation and inducing apoptosis in head and neck cancer cells, warranting its investigation for use in treatment of head and neck cancer.</p
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