Intravascular large B-cell lymphoma appearance on dual-energy computed tomography: a case report

Abstract Background Intravascular large B-cell lymphoma (IVLBCL) is the proliferation of neoplastic B lymphocytes in the vascular space. Since conventional computed tomography (CT) shows nonspecific findings, differentiation between IVLBCL and other lung diseases, such as diffuse interstitial lung disease, is difficult. Case presentation A 73-year-old man presented with dyspnea and hypoxemia. Laboratory findings showed an increased lactate dehydrogenase level of 1690 U/L (normal: 130–235 U/L) and soluble interleukin-2 receptor level of 1140 U/mL (normal: 157–474U/mL). Dual-energy CT iodine mapping showed a significant symmetrical decrease in iodine distribution in the upper lungs, suggesting an unusual distribution of pulmonary hypoperfusion. Therefore, IVLBCL was suspected. A random skin biopsy confirmed the diagnosis of IVLBCL. Due to the severity of the disease, lung biopsy was averted. After admission to the hospital, high-dose methotrexate was administered for central nervous system involvement, due to findings of suspected intracranial infiltration on a brain magnetic resonance imaging and elevated cell counts on lumbar puncture. Subsequently, oxygen demand improved, and rituximab along with cyclophosphamide, doxorubicin, vincristine, and prednisone was added to the patient’s regime. Eventually, oxygen administration was terminated, the patient’s general condition improved, and the patient was discharged after 47 days of hospitalization. Conclusions Since the diagnosis of IVLBCL depends on whether it is possible to suspect IVLBCL, the finding of decreased iodine perfusion demonstrated on dual-energy CT is considered important information for diagnosis. An immediate diagnosis of IVLBCL is needed to avoid rapid disease progression and introduce early treatment for a favorable prognosis. In this case, unique pulmonary hypoperfusion demonstrated by dual-energy CT promoted early diagnosis of IVLBCL

Identification of alcohol stress tolerance genes of Synechocystis sp. PCC 6803 using adaptive laboratory evolution

Abstract Background Synechocystis sp. PCC 6803 is an attractive organism for the production of alcohols, such as isobutanol and ethanol. However, because stress against the produced alcohol is a major barrier for industrial applications, it is highly desirable to engineer organisms with strong alcohol tolerance. Results Isobutanol-tolerant strains of Synechocystis sp. PCC 6803 were obtained by long-term passage culture experiments using medium containing 2 g/L isobutanol. These evolved strains grew on medium containing 5 g/L isobutanol on which the parental strain could not grow. Mutation analysis of the evolved strains revealed that they acquired resistance ability due to combinatorial malfunctions of slr1044 (mcpA) and slr0369 (envD), or slr0322 (hik43) and envD. The tolerant strains demonstrated stress resistance against isobutanol as well as a wide variety of alcohols such as ethanol, n-butanol, and isopentanol. As a result of introducing an ethanol-producing pathway into the evolved strain, its productivity successfully increased to 142% of the control strain. Conclusions Novel mutations were identified that improved the stress tolerance ability of various alcohols in Synechocystis sp. PCC 6803

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本研究では, 平成11年度及び12年度M県陸上競技短距離およびハードルの国体代表選手男子12名の70m走の全力疾走の疾走速度を測定し, その速度に関係があると思われるジャンプ能力と最大無酸素性パワーの体力要素について調査した。そして疾走速度との相関関係を調べ, 100m走のパフォーマンスに深い関係のある, 疾走中の最大速度に関係する体力要素を検討した。以下に, 今回明らかになった知見をまとめる。1)立幅跳, 立三段跳共に, 疾走速度と有意な相関を示した(立幅跳 : r=0.596,p<0.05,立三段跳 : r=0.621,p<0.05)。その理由として, これらのジャンプ運動は, 水平方向への跳躍であることから, 疾走運動に共通する動作を多く含んでいるためと考えられた。2)振込動作を行う, 行わないに関わらず, 垂直跳は疾走速度とは有意な相関はみられなかった。これは, 垂直跳の離地するまでの接地時間が長いこと, 短距離走とキックの特性が違うことが理由として考えられた。3)リバウンドドロップジャンプは, 振込動作を行ったジャンプの跳躍高だけが, 疾走速度と有意な相関を示した(r=0.624,p<0.05)。リバウンドドロップジャンプ指数が低い相関を示したのは, 被験者のほとんどが, トレーニングで筋の伸張-短縮形のジャンプ運動を実施していないことによると考えられた。4)最大無酸素性パワーは, 疾走速度と有意な相関は示さなかったが, 体重あたりの最大無酸素性パワーは有意な相関を示した(r=0.587,p<0.05)。以上のことから, 最大疾走速度9.02～10.20m/sの男子短距離・ハードル選手を対象の場合, 疾走速度に関係する体力要素は, (1)立幅跳, 立三段跳, (2)振込動作を行うリバウンドドロップジャンプの跳躍高, (3)体重あたりの最大無酸素性パワーであり, 疾走速度が速いほどこれらの数値が高くなる傾向がみられた。The purpose of this study is to examine the characteristics of physical fitness. Subjects were 12 male sprinters and hurdlers. They were representative athletes of M prefecture in the National Sports Festival in 1998 and 1999. The measured items were jumping ability and maximal anaerobic power in which the correlation coefficients between running velocity and their items were obtained. The results were summarized as follows : 1. Standing broad jump (SBJ) and standing triple jump (STJ) were correlated significantly with running velocity (SBJ : r=0.596,p<0.05,STJ : r=0.621,p<0.05). 2. Both heights of vertical jump with no-swing arms (VJ1) and swing arms (VJ2) were not correlated significantly with running velocity. Height of rebound drop jump with swing arms (RDJ2h) was correlated significantly with running velocity (r=0.624,p<0.05). But index of rebound drop jump (RDJ1i amd 2i) showed a low correlation with running velocity (1i : r=0.295,n.s., 2i : r=0.212,n.s.). 3. Maximal anaerobic power (MANP) was not correlated significantly with running velocity, but maximal anaerobic power per body weight (MANP/BW) was correlated significantly (r=0.587,p<0.05). These results suggest that if these values (SBJ, STJ, RDJ2h and MANP/BW) are higher, running velocity is faster

MOESM1 of Identification of alcohol stress tolerance genes of Synechocystis sp. PCC 6803 using adaptive laboratory evolution

Additional file 1. Additional figures, table, and details procedures for strain construction

Radiology of Fractures in Intoxicated Emergency Department Patients: Locations, Mechanisms, Presentation, and Initial Interpretation Accuracy.

The purpose of this study was to investigate the relationship of alcohol intoxication to time-to-presentation following injury, fracture type, mechanism of injury leading to fracture, and initial diagnostic radiology interpretation performance of emergency physicians versus diagnostic radiologists in patients who present to the emergency department (ED) and are subsequently diagnosed with fracture. Medical records of 1286 patients who presented to the ED and were diagnosed with fracture who also underwent plain film or computed tomography (CT) imaging were retrospectively reviewed. The subjects were divided into intoxicated and sober groups. Patient characteristics, injury-to-presentation time, fracture location, and discrepancies between initial clinical and radiological evaluations were compared. Of 1286 subjects, 181 patients were included in the intoxicated group. Only intoxicated patients presented with head/neck fractures more than 24 hours after injury. The intoxicated group showed a higher rate of head/neck fractures (skull 23.2% vs 5.8%, face and orbit 30.4% vs 9.5%; P &lt; 0.001) and a lower rate of extremity injuries. The rate of nondiagnosis of fractures by emergency physicians later identified by radiologists was the same in both groups (7.7% vs 7.7%, P = 0.984). While the same proportion of intoxicated patients presented more than 24 hours following injury, only intoxicated patients presented with craniofacial and cervical spinal fractures during this period. Alcohol-related injuries are more often associated with head/neck fractures but less extremity injuries. The rate of fractures missed by emergency physicians but later diagnosed by radiologists was the same in intoxicated and sober patients