Chaos synchronization between two different fractional systems of Lorenz family

This work investigates chaos synchronization between two different fractional order chaotic systems of Lorenz family. The fractional order Lü system is controlled to be the fractional order Chen system, and the fractional order Chen system is controlled to be the fractional order Lorenzlike system. The analytical conditions for the synchronization of these pairs of different fractional order chaotic systems are derived by utilizing Laplace transform. Numerical simulations are used to verify the theoretical analysis using different values of the fractional order parameter

Chaos Synchronization between Two Different Fractional Systems of Lorenz Family

This work investigates chaos synchronization between two different fractional order chaotic systems of Lorenz family. The fractional order Lü system is controlled to be the fractional order Chen system, and the fractional order Chen system is controlled to be the fractional order Lorenz-like system. The analytical conditions for the synchronization of these pairs of different fractional order chaotic systems are derived by utilizing Laplace transform. Numerical simulations are used to verify the theoretical analysis using different values of the fractional order parameter

Dacryocystorhinostomie endonasale Vs Dacryocystorhinostomie externe : La Préférence patient

Introduction :La prise en charge des sténoses lacrymo-nasales est exclusivement chirurgicale par Dacryocystorhinostomie (DCR), ce procédé peut être réalisé par voie externe longtemps considéré comme le gold-standars dans la prise en charge de ces pathologies ou alors par voie endonasale (end), plus esthétique. Le but de notre étude était entre autres d’analyser la préférence patient pour la voie endonasale.Matériels & Méthode :C’est une étude monocentrique, prospective de 117 DCR-end (97 patients). Ce travail consiste, à Comparer les résultats post-opératoires suivant les deux techniques (voie externe et voie endoscopique) et d’évaluer la préférence patient pour la voie endonasale.Résultats & commentaires : Le taux de réussite enregistré dans notre série était de 89,7% (105/117), un résultat moyen (perméabilité de la voie lacrymale à l’examen clinique avec persistance de la symptomatologie dans certaines situations) était considéré comme un échec soit 4,2% des cas (5/117).Seul des complications mineurs sont observé dans notre série à type de douleurs post-opératoire 5 cas (5,2%), hémorragie post-opératoire 3 cas (3,2%), synéchies du cornet inférieur 4 cas (4,1)Au dernier contrôle, de 6 mois ; 4 patients n’étaient pas satisfaits, et était indécis concernant le conseil de l’intervention à un ami, soit 95,9% de patients Satisfaits.Conclusion :La DCR endonasale est moyen sure et efficace dans la prise des sténoses lacrymo-nasales. Malheureusement elle ne fait toujours pas partie de l’arsenal thérapeutique dans beaucoup de centres hospitaliers qui traite de ces pathologies

Management of tiny unruptured intracranial aneurysms: A comparative effectiveness analysis

© 2017 American Medical Association. All rights reserved. Importance: Unruptured intracranial aneurysms (UIAs) are relatively common in the general population and are being increasingly diagnosed; a significant proportion are tiny (≤3 mm) aneurysms. There is significant heterogeneity in practice and lack of clear guidelines on the management of incidental, tiny UIAs. It is important to quantify the implications of different management strategies in terms of health benefits to patients. Objective: To evaluate the effectiveness of routine treatment (aneurysm coiling) vs 3 strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny UIAs. Design, Setting, and Participants: A decision-analytic model-based comparative effectiveness analysis was conducted from May 1 to June 30, 2017, using inputs from the medical literature. PubMed searches were performed to identify relevant literature for all key model inputs, each of which was derived from the clinical study with the most robust data and greatest applicability. Analysis included 10 000 iterations simulating adult patients with incidental detections of UIAs 3 mm or smaller and no history of subarachnoid hemorrhage. Interventions: The following 5 management strategies for tiny UIAs were evaluated: annual magnetic resonance angiography (MRA) screening, biennial MRA screening, MRA screening every 5 years, aneurysm coiling and follow-up, and no treatment or preventive follow-up. Main Outcomes and Measures: A Markov decision model for lifetime rupture was constructed from a societal perspective per 10 000 patients with incidental, tiny UIAs. Outcomes were assessed in terms of quality-adjusted life-years. Probabilistic, 1-way, and 2-way sensitivity analyses were performed. Results: In this analysis of 10000 iterations simulating adult patients with a mean age of 50 years, the base-case calculation shows that the management strategy of no treatment or preventive follow-up has the highest health benefit (mean [SD] quality-adjusted life-years, 19.40[0.31]). Among the management strategies that incorporate follow-up imaging, MRA every 5 years is the best strategy with the next highest effectiveness (mean [SD] quality-adjusted life-years, 18.05 [0.62]). The conclusion remains robust in probabilistic and 1-way sensitivity analyses. Noroutine follow-up remains the optimal strategy when the annual growth rate and risk of rupture of growing aneurysms are varied. When the annual risk of rupture of nongrowing UIAs is less than 1.7%(0.23% in base case scenario), no follow-up is the optimal strategy. If annual risk of rupture is more than 1.7%, coiling should be performed directly. Conclusions and Relevance: Given the current literature, no preventive treatment or imaging follow-up is the most effective strategy in patients with aneurysms that are 3mm or smaller, resulting in better health outcomes. More aggressive imaging surveillance for aneurysm growth or preventive treatment should be reserved for patients with a high risk of rupture. Given these findings, it is important to critically evaluate the appropriateness of current clinical practices, and potentially determine specific guidelines to reflect the most effective management strategy for patients with incidental, tiny UIAs

On New Generalized Ostrowski Type Integral Inequalities

The Ostrowski inequality expresses bounds on the deviation of a function from its integral mean. The aim of this paper is to establish some new inequalities similar to the Ostrowski's inequality. The current paper obtains bounds for the deviation of a function from a combination of integral means over the end intervals covering the entire interval in terms of the norms of the second derivative of the function. Some new perturbed results are obtained. Application for cumulative distribution function is also discussed

Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report

<p>Abstract</p> <p>Introduction</p> <p>Ovarian cancer ascitic fluid, which contains malignant cells, is usually present in women with an advanced stage disease. There are currently no effective therapies for the treatment of ovarian cancer ascitic fluid. We developed a new therapeutic strategy to target expression of the diphtheria toxin fragment A gene in ovarian tumor cells under the control of H19 regulatory sequences.</p> <p>Case presentation</p> <p>A 64-year-old Caucasian woman was diagnosed with a stage IIIc epithelial ovarian cancer. She suffered from progressive disease, accumulation of malignant ascites that needed to be drained weekly, abdominal pain, vomiting, anorexia and severe weakness. Infusion of the diphtheria toxin A chain-H19 plasmid into the peritoneum of our patient resulted in complete resolution of the ascites with minimum adverse events.</p> <p>Conclusion</p> <p>On the basis of this preliminary experience, we are currently conducting an extensive Phase I study on a larger number of patients in order to assess the safety and preliminary efficacy of this novel patient-oriented treatment approach.</p

Routh-Hurwitz Stability and Quasiperiodic Attractors in a Fractional-Order Model for Awareness Programs: Applications to COVID-19 Pandemic

This work explores Routh-Hurwitz stability and complex dynamics in models for awareness programs to mitigate the spread of epidemics. Here, the investigated models are the integer-order model for awareness programs and their corresponding fractional form. A non-negative solution is shown to exist inside the globally attracting set (GAS) of the fractional model. It is also shown that the diseasefree steady state is locally asymptotically stable (LAS) given that R0 is less than one, where R0 is the basic reproduction number. However, as R0>1, an endemic steady state is created whose stability analysis is studied according to the extended fractional Routh-Hurwitz scheme, as the order lies in the interval (0,2]. Furthermore, the proposed awareness program models are numerically simulated based on the predictor-corrector algorithm and some clinical data of the COVID-19 pandemic in KSA. Besides, the model's basic reproduction number in KSA is calculated using the selected data R0=1.977828168. In conclusion, the findings indicate the effectiveness of fractional-order calculus to simulate, predict, and control the spread of epidemiological diseases. © 2022 Taher S. Hassan et al

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy