Scan-Rescan Variation of Measures Derived from Brain Magnetization Transfer Ratio Histograms Obtained in Healthy Volunteers by Use of a Semi-interleaved Magnetization Transfer Sequence

Summary: A novel semiinterleaved gradient-echo (GE) sequence for quantitative measurement of magnetization transfer ratio (MTR) is described. With this sequence, several lines of k-space are collected for the non-MT image then several lines are collected for the MT image, thus building up the entire k-space in distinct acquisition blocks, with a good trade-off between motion-induced misregistration and degree of MT effect. The scan-rescan coefficients of variation for several MTR histogram-derived measures from 10 healthy volunteers scanned serially with this semiinterleaved sequence proved to be lower than those achieved using a conventional GE sequence. This sequence may be useful in a clinical environment to measure MTR changes over time more reliably than when acquiring the non-MT and MT images sequentially, which inevitably are affected by patient motion

Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques

<p></p><p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s40120-018-0103-2">https://link.springer.com/article/10.1007/s40120-018-0103-2</a></p><p></p><p></p><p> </p><p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p><br><p></p

SUITer: An Automated Method for Improving Segmentation of Infratentorial Structures at Ultra-High-Field MRI

  This folder contains Application datasets, described in El Mendili et al. J Neuroimaging. 2020 (https://doi.org/10.6084/m9.figshare.7886243.v1) Application datasets: - 20 preprocessed 7T T1w from 10 MS patients (A1 to A10) and 10 healthy controls (A11 to A20) (0.7 mm isotropic resolution). - 20 preprocessed 3T T1w from the same 10 MS patients and 10 healthy controls (0.8 mm isotropic resolution). Please use interpolate_T1w.sh script to generate Application_datasets images at 1mm isotropic resolution. Authors of publications or presentations that use  Application_datasets should cite:  El Mendili MM, Petracca M, Podranski K, Fleysher L, Cocozza S, Inglese M. SUITer: An Automated Method for Improving Segmentation of Infratentorial Structures at Ultra-High-Field MRI. J Neuroimaging. 2020 Jan;30(1):28-39. doi: 10.1111/jon.12672.</p

Demographic and clinical characteristics of all subjects.

<p>Data are presented as mean ± SD, unless otherwise indicated. Abbreviations: RR-MS = relapsing-remitting MS; PP-MS = primary-progressive MS; EDSS = Expanded Disability Status Scale; BSI = Brief Symptom Inventory; MFI = multidimensional fatigue inventory.</p><p>* <i>p</i> < 0.05 when compared to RR-MS group</p><p>** <i>p</i> < 0.001 when compared to RR-MS group</p><p>^¥ p < 0.001 when comparing to healthy controls</p><p>^{^} median and range</p><p>Demographic and clinical characteristics of all subjects.</p

Mean and standard deviation of Z-scores on neuropsychological tests.

<p>Abbreviations: RR-MS = relapsing-remitting MS; PP-MS = primary-progressive MS; CLVT = California Verbal Learning Test; SDMT = Symbol Digit Modalities Test; DKEFS-I = Delis—Kaplan Executive Function System Inhibition; DKEFS-IS = Delis—Kaplan Executive Function System Inhibition Switching; PASAT = Paced Auditory Serial Addition Test.</p><p>* p < 0.05</p><p>Mean and standard deviation of Z-scores on neuropsychological tests.</p

Mean and standard deviation of MRI measures for each subject group.

<p>RR-MS = relapsing-remitting MS; PP-MS = primary-progressive MS; All patients = both patients groups together (RR-MS & PP-MS); T2LV = T2-weighted lesion volume; T1LV = T1-weighted lesion volume; NBV = normalized brain volume; NGMV = normalized gray matter volume; NWMV = normalized white matter volume; Temporal MA = temporal lobe -medial aspect; Temporal LA = Temporal lobe—lateral aspect. Normalized volumes are in mL, cortical thickness is in mm, subcortical volume is in mm³.</p><p>* p < 0.05 when compared with control group</p><p>** p < 0.01 when compared with control group</p><p>*** p < 0.001 when compared with control group</p><p>^# p < 0.05 when compared with RR-MS group</p><p>Mean and standard deviation of MRI measures for each subject group.</p

Baseline and follow-up cortical lesion volumes and counts in patients with primary progressive multiple sclerosis.

<p>Baseline and follow-up cortical lesion volumes and counts in patients with primary progressive multiple sclerosis.</p

Reclassification of new cortical lesions.

<p>Baseline and follow up axial DIR (a, b) of the brain of a patient with primary progressive multiple sclerosis (PPMS) demonstrating a new focal lesion in the cortical grey matter (white-arrows) at follow-up. Corresponding baseline and follow-up axial PSIR (c, d) of the same patient with PPMS demonstrating focal lesions in the cortical grey matter (white-arrows) at both baseline and follow-up.</p

Retrospective analysis of new PSIR cortical lesions.

<p>Baseline and follow-up axial PSIR images of different patients with primary progressive MS demonstrating focal lesions in the cortical grey matter. Intracortical lesion that was too small to be counted at baseline (a, white arrow), but that enlarged and was counted on follow-up scan (b, white arrow). New LC lesion (d, white arrow) noted at follow-up but not at baseline (c).</p

Significant baseline and follow-up correlations between CL counts and volumes and clinical variables (without correction for age and gender).

<p>Significant baseline and follow-up correlations between CL counts and volumes and clinical variables (without correction for age and gender).</p