Utilisation de la langue naturelle pour l'interrogation de documents structurés

http://www.asso-aria.org/coria/2005/19.pdfInternational audienceLe langage de requête est l'indispensable interface entre l'utilisateur et l'outil de recherche. Simplifié au maximum dans les cas où les moteurs indexent essentiellement des documents plats, il devient fort complexe lorsqu'il s'adresse à des documents structurés et qu'il s'a git de définir des contraintes portant à la fois sur la structure et le contenu. L'approche ici- décrite propose d'utiliser la langue naturelle comme interface pour exprimer de telles requêtes. L'article décrit dans un premier temps les différentes phases qui permettent de transformer (dans un cadre de recherche d'information) la requête en langage naturel en une représentation sémantique indépendante du contexte. Des règles de simplification adaptées à la structure et au domaine du corpus sont ensuite appliquées, permettant d'obtenir une forme finale, adaptée à une conversion ver s un langage de requête formel. L'article décrit enfin les expérimentations effectuées et tir e les premières conclusions sur divers aspects de cette approche

0230: Effectiveness of switching Prasugrel's ‘low responders’ to ticagrelor after acute coronary syndrome

AimsThis study aimed to assess the effectiveness and safety of switching from Prasugrel to Ticagrelor patients identified as Prasugrel low-responders one month after ACS.Methods and results540 patients admitted for ACS with coronary stent implantation and discharged on Prasugrel 10mg were screened. Prasugrel response was assessed one month after discharge using Platelet Reactivity Index Vasodilatator Stimulated Phosphoprotein (PRI VASP). High on-Treatment Platelet Reactivity (HTPR) was defined as VASP>50%. Patients with HTPR were enrolled and switched to Ticagrelor 90 mg twice a day. They were re-tested a month later. Primary endpoint was defined as: comparison of degree of platelet inhibition and incidence of HTPR one month after switching to Ticagrelor in patients with HTPR on Prasugrel therapy. The safety endpoint was the incidence of bleedings under Ticagrelor as compared with Prasugrel therapy, using the Bleeding Academic Research Consensus definition.Between March 2010 and November 2013, 19 patients were defined as HTPR on Prasugrel 10 mg one month after ACS, with a mean VASP of 59,3%. Among these patients, 14 were switched to Ticagrelor 180 mg daily and, at one month, we observed a significant decrease in PRI VASP, with a mean value at 19.6% (p<0.001). No patients remained HTPR and 4 patients (28.4%) were identified as Very Low on-Treatment Platelet Reactivity (VLTPR) (VASP<10%). No ischemic events were reported after switching, while 3 patients (21%) suffered from bleeding complications (2 BARC1 and 1 BARC2 bleedings) during Ticagrelor therapy.ConclusionSwitch to Ticagrelor in Prasugrel's “low responders” patients is an effective strategy, leading to an adequate platelet inhibition in a large majority of patients. This biological tailored approach could be useful in preventing ischemic complications, in this specific high risk population, potentially increasing bleeding risk. This hypothesis needs to be confirmed in large clinical studies.Abstract 0230 – Figur

Two-photon intravital imaging of lungs during anthrax infection reveals long-lasting macrophage-dendritic cell contacts.

International audience: Dynamics of the lung immune system at a microscopic level are largely unknown because of inefficient methods to rid chest motion during image acquisition. In this study, we developed an improved intravital method for two-photon lung imaging uniquely based on a posteriori parenchymal tissue motion correction. We took advantage of the alveolar collagen pattern given by second harmonic generation signal as a reference for frame registration. We describe here for the first time a detailed dynamic account of two major lung immune cell populations, alveolar macrophages and CD11b-positive dendritic cells, during homeostasis and infection by spores of Bacillus anthracis, the agent of anthrax. We show that after alveolar macrophages capture spores, CD11b-positive dendritic cells come in prolonged contact with infected macrophages. Dendritic cells are known to carry spores to the draining lymph nodes and elicit the immune response in pulmonary anthrax. The intimate and long-lasting contacts between these two lines of defense may therefore coordinate immune responses in the lung through an immunological synapse-like process

Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B

DNA double strand-breaks (DSBs) are the most deleterious lesions that can affect the genome of living beings and are lethal if not quickly and properly repaired. Recently, we discovered a new family of anticancer agents designated as N-phenyl ureidobenzenesulfonates (PUB-SOs) that are blocking the cells cycle progression in S-phase and inducing DNA DSBs. Previously, we have studied the effect of several modifications on the molecular scaffold of PUB-SOs on their cytocidal properties. However, the effect of the nature and the position of substituents on the aromatic ring B is still poorly studied. In this study, we report the preparation and the biological evaluation of 45 new PUB-SO derivatives substituted by alkyl, alkoxy, halogen and nitro groups at different positions on the aromatic ring B. All PUB-SOs were active in the submicromolar to low micromolar range (0.24–20 μM). The cell cycle progression analysis showed that PUB-SOs substituted at position 2 by alkyl, halogen or nitro groups or substituted at position 4 by a hydroxyl group arrest the cell cycle progression in S-phase. Interestingly, all others PUB-SOs substituted at positions 3 and 4 arrested the cell cycle in G2/M-phase. PUB-SOs arresting the cell cycle progression in S-phase also induced the phosphorylation of H2AX (γH2AX) which is indicating the generation of DNA DSBs. We evidenced that few modifications on the ring B of PUB-SOs scaffold lead to cytocidal derivatives arresting the cell cycle in S-phase and inducing γH2AX and DSBs. In addition, this study shows that these new anticancer agents are promising and could be used as alternative to circumvent some of the biopharmaceutical complications that might be encountered during the development of PUB-SOs

Parallel FPGA Implementation of RSA with Residue Number Systems - Can side-channel threats be avoided? - Extended version

In this paper, we present a new parallel architecture to avoid side-channel analyses such as: timing attack, simple/differential power analysis, fault induction attack and simple/differential electromagnetic analysis. We use a Montgomery Multiplication based on Residue Number Systems. Thanks to RNS, we develop a design able to perform an RSA signature in parallel on a set of identical and independent coprocessors. Of independent interest, we propose a new DPA countermeasure in the framework of RNS. It is only (slightly) memory consuming (1.5 KBytes). Finally, we synthesized our new architecture on FPGA and it presents promising performance results. Even if our aim is to sketch a secure architecture, the RSA signature is performed in less than 160 ms, with competitive hardware resources. To our knowledge, this is the first proposal of an architecture counteracting electromagnetic analysis apart from hardware countermeasures reducing electromagnetic radiations