Pre-therapy process and outcome: A review of research instruments and findings

Pre-Therapy aims at stimulating psychological contact in persons suffering psychosis. We offer a review of Pre-Therapy research instruments and findings. The Pre-Therapy Rating Scale (PTRS, Prouty, 1994) and the Evaluation Criterion for the Pre-Therapy Interview (ECPI, Dinacci, 1997) have been the two most frequently used instruments for the assessment of psychological contact. PTRS scores seem more reliable than ECPI scores, but all manuals need revision. Particular attention is needed for the rating of nonverbal behavior. A preliminary evaluation of the structure of the PTRS indicates that it is two-dimensional rather than three-dimensional. The PTRS and the ECPI can be regarded as measures of communicative contact but also as measures of the meaningfulness of communication. Preliminary outcome studies suggest that pre-post and comparative effect sizes of Pre-Therapy are large for communicative contact, but the number of participants in these studies is generally low, as is the number of systematic case studies

Cell cycle specific radiosensitisation by the disulfiram and copper complex

The disulfiram and copper complex (DSF:Cu) has emerged as a potent radiosensitising anti-cancer agent. The ability of copper to stabilise DSF in a planar conformation and to inhibit DNA replication enzymes stimulated our investigation of the effect of DSF:Cu on cell cycle regulation. Flow cytometry and immunoblotting were used to assess the effect of DSF:Cu on cell cycle progression of the neuroblastoma cell line SK-N-BE(2c) and the glioma cell line UVW. Treatment with 0.1 and 0.3 μM DSF:Cu inhibited DNA synthesis in SK-N-BE(2c) and UVW cells, respectively. The increased potency of ionising radiation treatment induced by DSF:Cu and/or gemcitabine was determined by clonogenic assay. Treatment with 0.3 μM DSF:Cu resulted in greater radiation kill, exemplified by dose enhancement factor values of 2.64 and 2.84 in SKN-BE(2c) and UVW cells, respectively. Although DSF:Cu failed to sensitise S phase cells to irradiation, we observed that DSF:Cu radiosensitisation was potentiated by the S phase-specific cytotoxic drug gemcitabine. The efficacy of the combination treatment consisting of DSF:Cu, gemcitabine and ionising radiation was scheduledependent. Together, these results describe cell cycle specific radiosensitisation by DSF:Cu. The well-established toxicity profiles of DSF and gemcitabine should facilitate their evaluation as a combination treatment in patients undergoing radiotherapy

Anomalous dimension of subleading-power N-jet operators

We begin a systematic investigation of the anomalous dimension of subleading power N-jet operators in view of resummation of logarithmically enhanced terms in partonic cross sections beyond leading power. We provide an explicit result at the one-loop order for fermion-number two N-jet operators at the second order in the power expansion parameter of soft-collinear effective theory.Comment: 37 page

Tiled QR factorization algorithms

This work revisits existing algorithms for the QR factorization of rectangular matrices composed of p-by-q tiles, where p >= q. Within this framework, we study the critical paths and performance of algorithms such as Sameh and Kuck, Modi and Clarke, Greedy, and those found within PLASMA. Although neither Modi and Clarke nor Greedy is optimal, both are shown to be asymptotically optimal for all matrices of size p = q^2 f(q), where f is any function such that \lim_{+\infty} f= 0. This novel and important complexity result applies to all matrices where p and q are proportional, p = \lambda q, with \lambda >= 1, thereby encompassing many important situations in practice (least squares). We provide an extensive set of experiments that show the superiority of the new algorithms for tall matrices

Extracting partition statistics from semistructured data

The effective grouping, or partitioning, of semistructured data is of fundamental importance when providing support for queries. Partitions allow items within the data set that share common structural properties to be identified efficiently. This allows queries that make use of these properties, such as branching path expressions, to be accelerated. Here, we evaluate the effectiveness of several partitioning techniques by establishing the number of partitions that each scheme can identify over a given data set. In particular, we explore the use of parameterised indexes, based upon the notion of forward and backward bisimilarity, as a means of partitioning semistructured data; demonstrating that even restricted instances of such indexes can be used to identify the majority of relevant partitions in the data

Formal analysis of firewall policies

This dissertation describes a technique for formally analyzing a firewall security policy using a quasi-reduced multiway decision diagram model. The analysis allows a system administrator to detect and repair errors in the configuration of the firewall without a tedious manual inspection of the firewall rules.;We present four major contributions. First, we describe a set of algorithms for representing a firewall rule set as a multi-way decision diagram and for solving logical queries against that model. We demonstrate the application of these techniques in a tool for analyzing iptables firewalls. Second, we present an extension of our work that enables analysis of systems of connected firewalls and firewalls that use network address translation and other packet mangling rules. Third, we demonstrate a technique for decomposing a network into classes of equivalent hosts. These classes can be used to detect errors in a firewall policy without apriori knowledge of potential vulnerabilities. They can also be used with other firewall testing techniques to ensure comprehensive coverage of the test space. Fourth, we discuss a strategy for partially automating repair of the firewall policy through the use of counterexamples and rule history.;Using these techniques, a system administrator can detect and repair common firewall errors, such as typos, out-of-order rules, and shadowed rules. She can also develop a specification of the behaviors of the firewall and validate the firewall policy against that specification

Pressure buildup during CO2 injection in brine aquifers using the Forchheimer equation

If geo-sequestration of CO2 is to be employed as a key emissions reduction method in the global effort to mitigate climate change, simple yet robust screening of the risks of disposal in brine aquifers will be needed. There has been significant development of simple analytical and semi-analytical techniques to support screening analysis and performance assessment for potential carbon sequestration sites. These techniques have generally been used to estimate the size of CO2 plumes for the purpose of leakage rate estimation. A common assumption has been that both the fluids and the geological formation are incompressible. Consequently, calculation of pressure distribution requires the specification of an arbitrary radius of influence. In this talk, a new similarity solution is derived using the method of matched asymptotic expansions. By allowing for slight compressibility in the fluids and formation, the solution improves on previous work by not requiring the specification of an arbitrary radius of influence. A large-time approximation of the solution is then extended to account for non-Darcy inertial effects using the Forchheimer equation. Both solutions are verified by comparison with finite difference solutions. The results show that inertial losses will often be comparable, and sometimes greater than, the viscous Darcy-like losses associated with the brine displacement, although this is strongly dependent on formation porosity and permeability