Activated carbon-metal organic framework composite materials with enhanced gas adsorption capacity and process for the preparation thereof:US9433919B2

The present invention discloses activated carbon-metal organic framework composite materials (AC@MOF) with enhanced gas adsorption capacity. The present invention also discloses a process for the preparation of carbon-metal organic framework composite materials (AC@MOF). The present invention involves the use of “void space filling method” in metal organic frameworks (MOFs), which have been accomplished by in-situ addition of selected type and appropriate amount of activated carbon during the synthesis of MOF such as Cu-BTC, in the storage of gases such as methane. The gas adsorption capacity of these AC@MOF composite materials is significantly increased through this method.<br/

Activated carbon-metal organic framework composite materials with enhanced gas adsorption capacity and process for the preparation thereof:US9433919B2

The present invention discloses activated carbon-metal organic framework composite materials (AC@MOF) with enhanced gas adsorption capacity. The present invention also discloses a process for the preparation of carbon-metal organic framework composite materials (AC@MOF). The present invention involves the use of “void space filling method” in metal organic frameworks (MOFs), which have been accomplished by in-situ addition of selected type and appropriate amount of activated carbon during the synthesis of MOF such as Cu-BTC, in the storage of gases such as methane. The gas adsorption capacity of these AC@MOF composite materials is significantly increased through this method.<br/

Supplementary Figure 6 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 6 shows data from Ingenuity Pathway Analysis of colorectal cancer cells expressing NHE9, and the association between enrichment scores for Ca2+ signaling and NHE9 expression in colorectal cancer samples.</p

Supplementary Figure 3 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 3 shows the experimental protocol for measuring endosomal pH in colorectal cancer cells.</p

Supplementary Figure 9 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 9 shows data supporting the role of NHE9 on expression of MMP1 in colorectal cancer.</p

Supplementary Figure 2 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 2 shows data on how NHE9 expression corresponds with EMT status in normal epithelial and mesenchymal populations of the intestine, and in human cancer cells.</p

Supplementary Figure 4 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 4 shows how NHE9 affects cell apoptosis and cell cycle progression in colorectal cancer cells.</p

Supplementary Figure 5 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 5 shows NHE9 expression in primary and metastatic colorectal cancer patient samples.</p

Supplementary Table 1 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplemental Table 1 shows the parameter values for the mathematical model of endosomal pH.</p