L’Œuvre de Jan Václav Hugo Voříšek (1791-1825) dans la production pour piano de son époque et son interprétation aujourd’hui

Jan Václav Hugo Voříšek (1791-1825) has an indispensable role in the music history: being the creator of the genre impromptu, his visionary musical style has many qualities. His music has a great potential to speak to nowaday´s public, if well interpreted. This thesis wishes to fill three gaps in the existing treatment of the subject: the research in the field of the theory of interpretation, the comented critical edition and the work of the applied research – a complete recording on an instrument suitable to the repertoire. The text offers the results of the research and shows the possibilities of today´s interpretation of early music. First chapter treats composer´s life and artistic developpement, the second chapter orientates on general period interpretation and the third chapter analyses Voříšek´s solo piano music. Two practical annexes complete the thesis. One of them is the suggestion of changes in the existing edition, in order to fulfill the needs of the historically informed interpretation. The other one, the recording shows an interpretation based on a study of the musical sources and of the period practise, on an instrument close to the time of the genesis of the works performed. The aim was to apply the results of the theoretical research presented in the second and the third chapter of this thesis in the interpretation.Jan Václav Hugo Voříšek (1791 – 1825) a une importance réelle dans l'histoire de la musique notamment pour avoir fondé le genre de l'impromptu, et sa musique, au style résolument visionnaire en plusieurs points, est de qualité. Elle peut de plus séduire le public d'aujourd'hui pourvu qu'on la joue bien. La présente thèse souhaite combler trois lacunes : un travail dans le domaine de la thèorie de l’interprétation, une édition critique commentée, et la réalisation d’un travail de recherche appliquée – l’enregistrement intégral sur un instrument approprié. Le texte propose la recherche sur l’interprétation de la musique ancienne aujourd’hui. Le premier chapitre présente la vie du compositeur et son développement artistique. Le deuxième chapitre est consacré à des questions plus générales d’interprétation, illustrées par la suite sur les œuvres de Voříšek. Les problèmes concrets d’interprétation sont vus plus en détail dans le troisième chapitre, où les œuvres de Voříšek sont examinées. La thèse est complétée par deux annexes pratiques. La première propose l‘esquisse des changements nécessaires dans l’édition moderne de la partie la moins traitée auparavant, les Rapsodies op. 1. La deuxième est un enregistrement sonore des œuvres de Voříšek, qui présente l’interprétation basée sur l’étude de sources musicales et de la pratique de l’époque, sur l’instrument proche du temps de la naissance des œuvres joués

Mobilizing after disasters in advanced industrial democracies

Environmental disasters are frequently catalysts for social and political change. Yet, disasters of similar scale and impact seem to encourage collective action in some cases but fail to do so in others. For example, while some large oil spills have generated mass nationwide (and international) protests, others have gone largely unnoticed and protests, if any, remained small and localized. If disasters are political triggering events, as the existing literature suggests, why do they often fail to generate large scale collective action? In fact, why do some highly damaging industrial environmental disasters succeed, and others fail to catalyze protest movements? This research strives to explain a variation in the occurrence and size of non-violent protest after industrial environmental disasters in advanced democracies. I examine the mobilizing effects of disaster type and location, the underlying societal conditions conducive to protest, and the ‘language of disasters’ in post-disaster communication. I argue that in addition to grievances, resources, political opportunities, and framing, uncertainty about disaster impacts plays a crucial role in the protest mobilization process, one that has not been fully explored by scholars. Specifically, while uncertainty may have a dampening effect on protest mobilization, this effect is conditioned by people’s pre-existing beliefs, and particularly political ideology. Left-leaning (i.e., more liberal) individuals resist the dampening effect of uncertainty, while right-leaning (i.e., more conservative) individuals embrace it. This research draws on theories of social movements and framing as well as insights from previously studied disasters; it involves an in-depth analysis of cases of industrial disasters with large environmental impacts, including the 2014 Mount Polley mine leak, the 2010 Deepwater Horizon oil spill, and the 2011 Fukushima nuclear disaster. The cases were selected due to the varying protest sizes following these events. To allow for a systematic examination of different factors linked to post-disaster protest, this research employs several methods and tools, including a geographic information systems (GIS) analysis, qualitative comparative analysis (QCA), content analysis, and survey experiment. Such multi-method approach is most suitable for answering the variety and complexity of questions this research poses.Arts, Faculty ofPolitical Science, Department ofGraduat

The work of Jan Václav Hugo Voříšek (1791-1825) in the context of the period production and his interpretation today

Jan Václav Hugo Voříšek (1791 – 1825) a une importance réelle dans l'histoire de la musique notamment pour avoir fondé le genre de l'impromptu, et sa musique, au style résolument visionnaire en plusieurs points, est de qualité. Elle peut de plus séduire le public d'aujourd'hui pourvu qu'on la joue bien. La présente thèse souhaite combler trois lacunes : un travail dans le domaine de la thèorie de l’interprétation, une édition critique commentée, et la réalisation d’un travail de recherche appliquée – l’enregistrement intégral sur un instrument approprié. Le texte propose la recherche sur l’interprétation de la musique ancienne aujourd’hui. Le premier chapitre présente la vie du compositeur et son développement artistique. Le deuxième chapitre est consacré à des questions plus générales d’interprétation, illustrées par la suite sur les œuvres de Voříšek. Les problèmes concrets d’interprétation sont vus plus en détail dans le troisième chapitre, où les œuvres de Voříšek sont examinées. La thèse est complétée par deux annexes pratiques. La première propose l‘esquisse des changements nécessaires dans l’édition moderne de la partie la moins traitée auparavant, les Rapsodies op. 1. La deuxième est un enregistrement sonore des œuvres de Voříšek, qui présente l’interprétation basée sur l’étude de sources musicales et de la pratique de l’époque, sur l’instrument proche du temps de la naissance des œuvres joués.Jan Václav Hugo Voříšek (1791-1825) has an indispensable role in the music history: being the creator of the genre impromptu, his visionary musical style has many qualities. His music has a great potential to speak to nowaday´s public, if well interpreted. This thesis wishes to fill three gaps in the existing treatment of the subject: the research in the field of the theory of interpretation, the comented critical edition and the work of the applied research – a complete recording on an instrument suitable to the repertoire. The text offers the results of the research and shows the possibilities of today´s interpretation of early music. First chapter treats composer´s life and artistic developpement, the second chapter orientates on general period interpretation and the third chapter analyses Voříšek´s solo piano music. Two practical annexes complete the thesis. One of them is the suggestion of changes in the existing edition, in order to fulfill the needs of the historically informed interpretation. The other one, the recording shows an interpretation based on a study of the musical sources and of the period practise, on an instrument close to the time of the genesis of the works performed. The aim was to apply the results of the theoretical research presented in the second and the third chapter of this thesis in the interpretation

Soluble and EV-Associated Diagnostic and Prognostic Biomarkers in Knee Osteoarthritis Pathology and Detection

Osteoarthritis (OA) is the most common degenerative disease of the connective tissue of the human musculoskeletal system. Despite its widespread prevalence, there are many limitations in its diagnosis and treatment. OA diagnosis currently relies on the presence of clinical symptoms, sometimes accompanied by changes in joint X-rays or MRIs. Biomarkers help not only to diagnose early disease progression but also to understand the process of OA in many ways. In this article, we briefly summarize information on articular joints and joint tissues, the pathogenesis of OA and review the literature about biomarkers in the field of OA, specifically inflammatory cytokines/chemokines, proteins, miRNA, and metabolic biomarkers found in the blood, synovial fluid and in extracellular vesicles

Soluble and EV-Associated Diagnostic and Prognostic Biomarkers in Knee Osteoarthritis Pathology and Detection

Osteoarthritis (OA) is the most common degenerative disease of the connective tissue of the human musculoskeletal system. Despite its widespread prevalence, there are many limitations in its diagnosis and treatment. OA diagnosis currently relies on the presence of clinical symptoms, sometimes accompanied by changes in joint X-rays or MRIs. Biomarkers help not only to diagnose early disease progression but also to understand the process of OA in many ways. In this article, we briefly summarize information on articular joints and joint tissues, the pathogenesis of OA and review the literature about biomarkers in the field of OA, specifically inflammatory cytokines/chemokines, proteins, miRNA, and metabolic biomarkers found in the blood, synovial fluid and in extracellular vesicles

The Effect of Mycotoxin Deoxynivalenol on Haematological and Biochemical Indicators and Histopathological Changes in Rainbow Trout (Oncorhynchus mykiss)

Deoxynivalenol (DON), produced by the Fusarium genus, is a major contaminant of cereal grains used in the production of fish feed. The effect of mycotoxin deoxynivalenol on rainbow trout (Oncorhynchus mykiss) was studied using a commercial feed with the addition of DON in a dose of 2 mg/kg feed. The fish (n=40) were exposed to the mycotoxin for 23 days. The trout were divided into two groups, control and experimental groups. Control groups were fed a commercial feed naturally contaminated with a low concentration of DON (225 μg/kg feed); experimental groups were fed a commercial feed with the addition of DON (1964 μg/kg feed). Plasma biochemical and haematological indices, biometric parameters, and histopathological changes were assessed at the end of the experiment. The experimental groups showed significantly lower values in MCH (P<0.05). In biochemical indices, after 23-day exposure, a significant decrease in glucose, cholesterol (P<0.05), and ammonia (P<0.01) was recorded in the experimental group compared to the control group. Our assessment showed no significant changes in biometric parameters. The histopathological examination revealed disorders in the caudal kidney of the exposed fish. The obtained data show the sensitivity of rainbow trout (O. mykiss) to deoxynivalenol

Transcriptomic Analysis of Macrophage Polarization Protocols: Vitamin D₃ or IL-4 and IL-13 Do Not Polarize THP-1 Monocytes into Reliable M2 Macrophages

Two main types of macrophages (Mφ) include inflammatory (M1) and anti-inflammatory (M2) macrophages. These cells can be obtained in vitro by polarization of monocytic cell lines using various stimuli. Since there is currently no consensus on the best method for the acquisition of reliable M1 and M2 macrophages from the THP-1 cell line, we decided to compare three different polarization protocols at the transcriptomic level. Whole transcriptomes of Mφ polarized according to the chosen protocols were analyzed using RNA-seq. Differential expression of genes and functional enrichment for gene ontology terms were assessed. Compared with other protocols, M1 macrophages polarized using PMA (61.3 ng/mL) and IFN-γ along with LPS had the highest expression of M1-associated regulatory genes and genes for M1 cytokines and chemokines. According to the GO enrichment analysis, genes involved in defensive and inflammatory processes were differentially expressed in these Mφ. However, all three chosen protocols which use Vit D3, IL-13/IL-4, and IL-4, respectively, failed to promote the polarization of macrophages with a reliable M2 phenotype. Therefore, optimization or development of a new M2 polarization protocol is needed to achieve macrophages with a reliable anti-inflammatory phenotype

Mesenchymal Stem Cells in the Treatment of Human Spinal Cord Injury: The Effect on Individual Values of pNF-H, GFAP, S100 Proteins and Selected Growth Factors, Cytokines and Chemokines

At present, there is no effective way to treat the consequences of spinal cord injury (SCI). SCI leads to the death of neural and glial cells and widespread neuroinflammation with persisting for several weeks after the injury. Mesenchymal stem cells (MSCs) therapy is one of the most promising approaches in the treatment of this injury. The aim of this study was to characterize the expression profile of multiple cytokines, chemokines, growth factors, and so-called neuromarkers in the serum of an SCI patient treated with autologous bone marrow-derived MSCs (BM-MSCs). SCI resulted in a significant increase in the levels of neuromarkers and proteins involved in the inflammatory process. BM-MSCs administration resulted in significant changes in the levels of neuromarkers (S100, GFAP, and pNF-H) as well as changes in the expression of proteins and growth factors involved in the inflammatory response following SCI in the serum of a patient with traumatic SCI. Our preliminary results encouraged that BM-MSCs with their neuroprotective and immunomodulatory effects could affect the repair process after injury