The use of a combined bipedicled axial perforator based fasciocutaneous flap for the treatment of a traumatic diabetic foot wound: a case report

The axial and perforator vascularised fasciocutaneous flaps are reliable and effective treatment methods for covering lower limb post-traumatic, septic, Charcot, and diabetic foot wounds. The authors describe the unique utilisation of a hybrid flap as an axial-perforator flap combination for the treatment of a traumatic diabetic foot wound

Vinorelbine-based chemotherapy in hormone refractory prostate cancer

Background: No consensus exists regarding further therapy for the management of hormone-refractory prostate cancer. In this phase II study, the combination of Vinorelbine with 5-Fluorouracil and folinic acid (FLN regimen) was evaluated in patients with progressive or resistant disease after hormone therapy. Patients and Methods: Thirty-four patients were treated with Vinorelbine at a dose of 20 mg/m 2 intravenously (i.v.) on days 1 and 3, folinic acid (FA), 100 mg/m 2 i.v. and 5-Fluorouracil (5-FU), 350 mg/m 2 i.v. as a short infusion on days 1 to 3. The therapy was given in an out-patient setting, every 3 weeks. Results: All of the 34 eligible patients were evaluable for toxicity and 30 for activity. A total of 127 cycles was administered (91% at full dose). Among the 15 patients with measurable disease, four had a partial response (26.6%; C.I. 95%, 28.3% to 65.7%) and four achieved stable disease. In 14 patients (47%) a clinical benefit was documented. Six out of 15 patients with bone-only involvement had stable disease (40%). The median duration of stabilization and partial response was 16 weeks (range 4-24 weeks). The most common toxicity was hematological: Grade 4 (NCI-CTC scale) in five patients at re-cycle. Other toxicities were of low incidence and easy to manage. Conclusion: The encouraging results obtained with the FLN regimen in terms of clinical benefit and its predictable and manageable toxicity support the palliative role of this chemotherapeutic strategy in hormone-refractory prostate patients

Data mining and neural networks to determine the financial market prediction

Predicting stock market movements has been a complex task for years by gaining the increasing interest of researchers and investors present all around the world. These have tried to get ahead of the way in order to know the levels of return and thus reduce the risk they face in investments [1]. Capital markets are areas of fundamental importance for the development of economies and their good management that favors the transition from savings to investment through the purchase and sale of shares [2]. These actions are so important that they are influenced by economic, social, political, and cultural variables. Therefore, it is reasonable to consider the value of an action in an instant not as a deterministic variable but as a random variable, considering its temporal trajectory as a stochastic process

COMPARATIVE STUDY OF VIBRATIONS IN APPARATUS COMBINATIONS TANGENTIAL THRESHING

          Vibrations are dynamics phenomenon which appear in some environment as a result of an external force whose action consist on an oscillation. The effect of these oscillations harm to the environment where they appear and if this environment is the human body then the results are more harmful, hauling consequences, sometimes irreversible, on the health of the human body. In this respect, studying and knowing the effects of the vibrations on human body have become a necessity, the research taking place in order to find out the limit to which the men could work in an environment with vibrations such as the agricultural machinery (self-propelled combines for cereals crop in a way) without no effects on the health of human being

AGRICULTURE 4.0 - THE USE OF SMART TECHNOLOGIES FOR HIGHPERFORMANCE AGRICULTURE

Given that the labor market in Romania has an acute shortage of labor (about 1 million people), in agriculture this lack is felt even more acutely because the population in the villages is declining and aging, thus it is increasingly difficult for Romanian farmers to find labor, let alone skilled labor. One solution can be the digitization of agriculture, ie the introduction of the latest management concepts, sensors, automation, robots, etc. in the modernization of work processes in agriculture, thus reducing the need for labor, while increasing productivity and efficiency in agriculture

Design of a decision support system for improving air quality assessment

Establishing a system that allows the transition from environmental and traffic monitoring to environmental management at the personal level has become a necessity. Such a system will improve the life quality, reduce health costs and increase the support of vulnerable groups (i.e., the elderly, children). ESTABLISH project aims to advance an innovative platform which allows converting environmental (sensor) data into actionable information for users to provide a healthier and safer environment thereby improving the quality of life. Smart adaptive services providing real-time feedback tailored to specific user and application needs will be developed by combining networked sensors and other data sources with adaptive models. This paper will present the on-going research within the ESTABLISH project related to the development of a decision support component which assesses the air quality. Based on real-time monitoring and quantification methods, and certain types of notifications for risk groups and general populations, the proposed system links pollutant concentrations to individual health risks. The proposed decision support for air quality assessment is structured on two components. The first component is represented by the comparison with the limit values provided by the legislation, and the second is the forecast of near-real-time air pollution episodes (based on trigger values). Thus, for each pollutant considered (PM2.5, PM10, SO2, NO2, O3, and CO) the frequency of pollutants concentrations measurement, the averaging periods according to the legislation, the averaging period and the limit values used for the notification component were established