Ponseti method for treatment of idiopathic congenital talipes equinovarus at tertiary care center in India

Background: Different treatment methods were tried with variable success rates but Ponseti method of serial casting and manipulation stood apart due to better understanding of foot biomechanics and became accepted choice of treatment worldwide.Methods: 50 patients were enrolled in the study out of which 40 were available for final follow-up. We studied 40 cases during October 2018 to December 2020 at Government Medical College, Aurangabad. Out of 40 cases 31 were male and 9 were female. 25 were unilateral and 15 were bilateral. All cases were idiopathic. 4 inches Plaster of Paris (POP) bandages were cut into half and such 2 inches POP bandages were used for casting. Tenotomies were performed under controlled environment of Operation Theater with general anaesthesia. Number 12 surgical blade was used. Dennis-Browne splint was used for maintenance of correction.Results: Out of total 55 feet studied, 10 feet (18.18%) required tendo Achilles tenotomy and 45 feet (81.82%) were treated with casting alone. There were 8 cases of relapses (20%). All relapsed cases were treated with repeat casting as per Ponseti protocol and none of them required repeat tenotomy. Complications related to plaster were minimal and there were no incidence of rocker bottom deformity.Conclusions: We conclude that in a low income developing country like India where case load is very high; Ponseti method is effective, inexpensive form of treatment with minimal complications. Need for extensive soft tissue procedures vastly reduced with this method

Role of trimetazidine in carbon tetrachloride induced liver damage in rats

Background: Hepatotoxicity by chemicals and drugs is a common clinical problem. Presently very few drugs are showing effectiveness in prevention and treatment of hepatic damage. So in this study, we evaluated the role of trimetazidine in carbon tetrachloride (CCl4) induced liver damage in rats. Objective of current study is to evaluate effects of prophylactic trimetazidine against carbon tetrachloride induced liver damage in rats.Methods: Liver damage was induced in 30 albino rats by CCl4 (0.5 ml/kg, i.p.) once daily for 7 days. Extent of damage was studied by assessing biochemical parameters (SGOT, SGPT, ALP, proteins and bilirubin). These biochemical observations were supplemented by pentobarbitone Sleeping Time and Histological Examination of liver. The effect of co-administration of trimetazidine (doses 5 and 10 mg/kg p. o.) on the above parameters was investigated. Liv.52® was used as Positive Control. Data was analyzed by one way ANOVA, followed by Dunnett's test.Results: Trimetazidine significantly prevented CCl4 induced elevation of serum SGOT, SGPT, ALP and bilirubin (total and direct), and reduction in protein level. Pentobarbitone sleeping time and histological examination of the liver showed consistent results. The results were comparable to that of Liv.52®.Conclusions: Trimetazidine, when administered prophylactically, shows hepatoprotective effect against CCl4 induced liver damage

Anomalous pinning behavior in an incommensurate two-chain model of friction

Pinning phenomena in an incommensurate two-chain model of friction are studied numerically. The pinning effect due to the breaking of analyticity exists in the present model. The pinning behavior is, however, quite different from that for the breaking of analyticity state of the Frenkel-Kontorova model. When the elasticity of chains or the strength of interchain interaction is changed, pinning force and maximum static frictional force show anomalously complicated behavior accompanied by a successive phase transition and they vanish completely under certain conditions.Comment: RevTex, 9 pages, 19 figures, to appear in Phys. Rev. B58 No.23(1998

Atomic Scale Sliding and Rolling of Carbon Nanotubes

A carbon nanotube is an ideal object for understanding the atomic scale aspects of interface interaction and friction. Using molecular statics and dynamics methods different types of motion of nanotubes on a graphite surface are investigated. We found that each nanotube has unique equilibrium orientations with sharp potential energy minima. This leads to atomic scale locking of the nanotube. The effective contact area and the total interaction energy scale with the square root of the radius. Sliding and rolling of nanotubes have different characters. The potential energy barriers for sliding nanotubes are higher than that for perfect rolling. When the nanotube is pushed, we observe a combination of atomic scale spinning and sliding motion. The result is rolling with the friction force comparable to sliding.Comment: 4 pages (two column) 6 figures - one ep

Tag retention, wound healing, and subsequent reproductive history of southern right whales following satellite-tagging

This paper presents data from 48 resightings of 16 southern right whales that were satellite-tagged on the South African coast in September 2001, up to and including 2012. Tag performance in terms of number of days with locations received was significantly higher in males than females, and lowest in cows with calves, and attributed to behavioral differences leading to variable degrees of antenna damage. Resightings occurred from 4 to 4,054 d after tagging: tags were retained in all whales seen within 27 mo, but were apparently shed in all but one individual seen within 36 mo of tagging. The exception was a whale that still had the tag present 11 yr after tagging. Healing at the tag site occurred gradually and within 5 yr of tagging (and 2 yr after tag shedding). No significant difference in the subsequent frequency of calving was detected between 12 tagged and 382 untagged females photographed contemporaneously, and although statistical power was low, a 21% or greater reduction in calving rate in tagged females would seem incompatible with the observations. The death of one female 3 yr after tagging was more likely attributable to a ship strike on an animal debilitated by a prolapsed uterus.U.S. National Marine Fisheries Service, Office of Naval Research and gifts from donors to the Oregon State University Marine Mammal Program.http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1748-76922016-04-30hb201

Reef Coral Reproduction in the Eastern Pacific: Costa Rica, Panamá, and the Galápagos Islands (Ecuador). VI. Agariciidae, Pavona clavus

The reproductive ecology of the zooxanthellate reef coral Pavona clavus was investigated at several sites in Costa Rica, Panama, and the Galapagos Islands (Ecuador) over the period 1985–2009. Pavona clavus displayed stable gonochorism as only five hermaphrodites were found in 590 samples. At four of five locations, sex ratios were skewed toward female dominance; however, at Saboga Island (Panama) male colonies predominated. In Panama, sexual maturity was observed in an estimated eight year old female colony, and several colonies of 10–20 years of age demonstrated gametogenesis. Sexual activity was observed at all study sites, but gamete development occurred in only 14–31% of colonies sampled sporadically. Seasonality of gametogenic activity occurred predominantly during the warm/wet season, June to August, at mainland sites (Cano Island, Costa Rica, and Gulfs of Chiriqui and Panama, Panama). This pattern was repeated in the Galapagos Islands, but mainly from March to May when seasonally high sea temperatures and rainfall prevailed there. Histological sampling and field observations indicated that spawning was centered around the full moon, most frequently on lunar day 17, and near sunset (1,800 h). Mean fecundity (mature ova cm-2 live tissue) estimates were significantly different for two sites and ranged from ~1,780 (Saboga Island, Gulf of Panama, seasonally upwelling) to ~4,280 (Uva Is, Gulf of Chiriqui, nonupwelling). Assuming three annual spawning events colony-1 (August, September, October), extrapolation of minimum and maximum fecundities yield 5,340 and 12,840 ova cm-2 year-1. Seasonal, lunar, and diel spawning patterns in nine zooxanthellate species at Uva Island indicate asynchronous coral community spawning

Coastal, offshore, and migratory movements of South African right whales revealed by satellite telemetry

In September 2001, 21 satellite-monitored radio tags were deployed on southern right whales in South African waters, 15 of which transmitted for 25-161 d. Most coastwise movement on the south coast occurred in a westerly direction with cow-calf pairs moving slowest. Three whales tagged on the west coast and one tagged on the south coast moved north into St Helena Bay, a probable feeding ground, where residence times were 36-100 d. Five animals tracked after leaving the coast maintained a bearing of 201-220o before branching out over the southeast Atlantic from 37-60o S and between 13o W and 16o E, travelling 3800-8200 km over the ensuing 53-110 d before transmissions ceased. Their locations were categorized as migrating or nonmigrating based on the relative orientation of the track and net speed. An average of 42% of non-migrating locations were between 37-45o S and 53% south of 52o S, possibly associated with the Sub Tropical Convergence and Antarctic Polar Front respectively. Whaling data suggest right whales fed largely on copepods at the former and euphausiids at the latter. If the non-migrating locations represented feeding at these frontal zones, switching between them would seem to have obvious cost-benefit implications.P. B. B. acknowledges the support of the National Research Foundation of South Africa (GUN number 2047517). B. R. M. acknowledges the support of the National Oceanic and Atmospheric Administration through the Northeast Consortium, based at the University of New Hampshire (Grant #NA16FL1324), the U.S. Office of Naval Research, and donors to the Oregon State University Endowed Marine Mammal Program.http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1748-7692ab201

A Pulsed-air Model of Blue Whale B Call Vocalizations

Blue whale sound production has been thought to occur by Helmholtz resonance via air flowing from the lungs into the upper respiratory spaces. This implies that the frequency of blue whale vocalizations might be directly proportional to the size of their sound-producing organs. Here we present a sound production mechanism where the fundamental and overtone frequencies of blue whale B calls can be well modeled using a series of short-duration (\u3c1 \u3es) wavelets. We propose that the likely source of these wavelets are pneumatic pulses caused by opening and closing of respiratory valves during air recirculation between the lungs and laryngeal sac. This vocal production model is similar to those proposed for humpback whales, where valve open/closure and vocal fold oscillation is passively driven by airflow between the lungs and upper respiratory spaces, and implies call frequencies could be actively changed by the animal to center fundamental tones at different frequency bands during the call series