Singular stress field near the edge of interface of bonded dissimilar materials with an interlayer

AbstractFor bonded dissimilar materials, the free-edge stress singularity usually prevails near the intersection of the free-surface and the interface. When two materials are bonded by using an adhesive, an interlayer develops between the two bonded materials. When a ceramic and a metal are bonded, the residual stress develops because of difference in the coefficient of thermal expansion. An interlayer may be inserted between the two materials to defuse the residual stress. Stress field near the intersection of the interface and free-surface in the presence of the interlayer is then very important for evaluating the strength of bonded dissimilar materials.In this study, stress distributions on the interface of bonded dissimilar materials with an interlayer were calculated by using the boundary element method to investigate the effect of the interlayer on the stress distribution. The relation between the free-edge singular stress fields of bonded dissimilar materials with and without an interlayer was investigated numerically. It was found that the influence of the interlayer on the stress distributions was confined within a small area of the order of interlayer thickness around the intersection of the interface and the free-surface when the interlayer was very thin. The stress distribution near the intersection of the interface and the free-surface was controlled by the free-edge stress singularity of the bonded dissimilar materials without the interlayer. In this case, the interlayer can be called free-edge singularity-controlled interlayer. If a stress distribution on the interface is known for one thickness of an interlayer h, stress distributions on the interface for other values of h can be estimated

Secondary electrons induced by fast ions under channeling conditions. I. Production and emission of secondary electrons

Energy spectra of ion-induced secondary electrons emitted from Si and GaAs single crystals have been measured for various ions with a velocity of 3.75 MeV/amu. A simple Z12-scaling behavior of the electron yields indicates that the observed keV electrons stem from simple binary collisions between the ions and the target electrons. Measurements for GaAs crystals preamorphized with 2-keV Ar+ ions provide evidence for the localization of the binary collisions near the surface region under channeling incidence conditions. Furthermore, these measurements are used to determine the effective target thicknesses both for channeling and random incidence conditions

Regulating divergent transcriptomes through mrna splicing and its modulation using various small compounds

Human transcriptomes are more divergent than genes and contribute to the sophistication of life. This divergence is derived from various isoforms arising from alternative splicing. In addition, alternative splicing regulated by spliceosomal factors and RNA structures, such as the RNA G-quadruplex, is important not only for isoform diversity but also for regulating gene expression. Therefore, abnormal splicing leads to serious diseases such as cancer and neurodegenerative disorders. In the first part of this review, we describe the regulation of divergent transcriptomes using alternative mRNA splicing. In the second part, we present the relationship between the disruption of splicing and diseases. Recently, various compounds with splicing inhibitor activity were established. These splicing inhibitors are recognized as a biological tool to investigate the molecular mechanism of splicing and as a potential therapeutic agent for cancer treatment. Food-derived compounds with similar functions were found and are expected to exhibit anticancer effects. In the final part, we describe the compounds that modulate the messenger RNA (mRNA) splicing process and their availability for basic research and future clinical potential

Pyogenic Liver Abscess: a Study of 18 Patients

Eighteen patients with pyogenic liver abscess were treated at Hiroshima University Hospital, First Department of Surgery and Hiroshima Memorial Hospital between 1979 and August 1984. The most frequent cause of the disease was infection of the biliary tract, accounting for 44%. The most useful diagnostic methods were echography and CT. The use of these, two techniques enabled us to establish diagnosis in almost all the patients. Sufficient drainage of the biliary tract was important in cases of hepatic abscess via the biliary tract. In other causes of hepatic abscess, drainage under echographic guidance was useful in treatment for solitary liver abscess. In cases of multiple liver abscess, it was also considered necessary to puncture the abscess under echographic guidance, to detect the causative organisms, and to use effective antibiotics against that organisms

シングルセルRNAシーケンシングによる1,25-ジヒドロキシビタミンD3反応性Fgf23発現骨細胞の同定

Fibroblast growth factor 23 (FGF23), a hormone, mainly produced by osteocytes, regulates phosphate and vitamin D metabolism. By contrast, 1,25-dihydroxyvitamin D3, the active form of vitamin D, has been shown to enhance FGF23 production. While it is likely that osteocytes are heterogenous in terms of gene expression profiles, specific subpopulations of Fgf23-expressing osteocytes have not been identified. Single-cell RNA sequencing (scRNA-seq) technology can characterize the transcriptome of an individual cell. Recently, scRNA-seq has been used for bone tissue analysis. However, owing to technical difficulties associated with isolation of osteocytes, studies using scRNA-seq analysis to characterize FGF23-producing osteocytes are lacking. In this study, we characterized osteocytes secreting FGF23 from murine femurs in response to calcitriol (1,25-dihydroxyvitamin D3) using scRNA-seq. We first detected Dmp1, Mepe, and Phex expression in murine osteocytes by in situ hybridization and used these as marker genes of osteocytes. After decalcification, enzyme digestion, and removal of CD45+ cells, femoral bone cells were subjected to scRNA-seq. We identified cell clusters containing osteocytes using marker gene expression. While Fgf23 expression was observed in some osteocytes isolated from femurs of calcitriol-injected mice, no Fgf23 expression was detected in untreated mice. In addition, the expression of several genes which are known to be changed after 1,25-dihydroxyvitamin D3 treatment such as Ccnd2, Fn1, Igfbp7, Pdgfa, and Timp1 was also affected by calcitriol treatment in Fgf23-expressing osteocytes, but not in those lacking Fgf23 expression, even after calcitriol administration. Furthermore, box-and-whisker plots indicated that Fgf23 expression was observed in osteocytes with higher expression levels of the Fam20c, Dmp1, and Phex genes, whose inactivating mutations have been shown to cause FGF23-related hypophosphatemic diseases. These results indicate that osteocytes are heterogeneous with respect to their responsiveness to 1,25-dihydroxyvitamin D3, and sensitivity to 1,25-dihydroxyvitamin D3 is one of the characteristics of osteocytes with Fgf23 expression. It is likely that there is a subpopulation of osteocytes expressing several genes, including Fgf23, involved in phosphate metabolism

A Planetary Companion to the Intermediate-Mass Giant HD 100655

A precise radial velocity survey conducted by a Korean-Japanese planet search program revealed a planetary companion around the intermediate-mass clump giant HD 100655. The radial velocity of the star exhibits a periodic Keplerian variation with a period, semi-amplitude and eccentricity of 157.57 d, 35.2 m s^-1 and 0.085, respectively. Adopting an estimated stellar mass of 2.4 M_Sun, we confirmed the presence of a planetary companion with a semi-major axis of 0.76 AU and a minimum mass of 1.7 M_Jup. The planet is the lowest-mass planet yet discovered around clump giants with masses greater than 1.9 M_Sun.Comment: 17 pages, 8 figures, accepted for publication in PAS