6 research outputs found
Beam test performance of a prototype module with Short Strip ASICs for the CMS HL-LHC tracker upgrade
The Short Strip ASIC (SSA) is one of the four front-end chips designed for the upgrade of the CMS Outer Tracker for the High Luminosity LHC. Together with the Macro-Pixel ASIC (MPA) it will instrument modules containing a strip and a macro-pixel sensor stacked on top of each other. The SSA provides both full readout of the strip hit information when triggered, and, together with the MPA, correlated clusters called stubs from the two sensors for use by the CMS Level-1 (L1) trigger system. Results from the first prototype module consisting of a sensor and two SSA chips are presented. The prototype module has been characterized at the Fermilab Test Beam Facility using a 120 GeV proton beam
Gravitational Focusing of Non−Relativistic Dark Matter Streams by the Earth.
In this report, we investigate how monochromatic streams of low-velocity dark matter are gravitationally lensed by the Earth. Specifically, it is found that an incoming Dark Matter stream from sufficiently far away, exhibits significant amplification in its original flux at the Earth's surface when is initiated with a speed of 8.8 km s. The computational evolution of the equations of motion was performed with the VelocityVerlet algorithm with a timediscretization parameter of s
Comparative p16(IKN4A) Expression in Laryngeal Carcinoma and Cervical Cancer Precursors: A Real-time Grid-based Immunocytochemistry Analysis
Background/Aim: p16 (gene locus: 9p21) tumor suppressor gene is
considered an important biomarker for the progression and prognosis in a
variety of malignancies and pre-cancerous lesions, including high-risk
(HR-) human papilloma virus (HPV)-mediated squamous intraepithelial
lesions (SILs), based on cytological and the corresponding cervical
intraepithelial neoplasia (CIN) histopathological categorization. p16
acts as a cyclin-dependent kinase-4 inhibitor negatively regulating the
cell cycle. In persistent HPV infection, E7 oncogenic protein binds
retinoblastoma protein leading to its proteolytic transformation, also
triggering E2F dissociation, which increases DNA transcription and
progression to S phase. This mechanism promotes aberrant p16
over-expression. Our aim was to comparatively analyze p16 protein
expression patterns in laryngeal squamous cell carcinomas (LSCC) and
also in SILs. Materials and Methods: Fifty (n=50) primary LSCCs tissues
all non-HPV-dependent, and a set of 50 liquid-based SILs, were analyzed
by immunohistochemistry and immunocytochemistry, respectively.
Concerning the screening process in cytological slides, a novel
real-time reference and calibration grid platform was implemented and
employed. Results: Decreased protein expression was observed in 34/50
(68%) tissues regarding LSCCs. Overall p16 expression was associated to
smoking status of the patients (p=0.001), and also with the p-stage of
the examined malignancies (p=0.033). A strong statistical significance
was assessed correlating LSIL/HSIL cases with a progressive p16 over
expression (p=0.001), also reflecting a higher CIN diagnosis (p=0.001).
Conclusion: p16 down- regulation is a frequent genetic event in LSCCs,
which is associated with advanced disease. In contrast to this, p16
over- expression triggered by a specific molecular mechanism shows a
strong relationship with a progressively aggressive phenotype due to
upgraded SIL/CIN cervical categorization. The first described
application of the grid platform demonstrated a considerable improvement
in the immunocytochemistry slide screening process enhancing the
diagnostic reliability
Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma
Background: Oral squamous cell carcinoma (OSCC) is an aggressive
neoplasm. Many chromosomal and gene alterations have been identified in
OSCC, including structural and numerical changes. In this study, we
implemented a molecular assay of chromosome 7 (Chr7) in order to
investigate the level of its numerical instability in OSCC. Materials
and Methods: Using tissue microarray technology, 30 primary OSCCs were
cored and re-embedded into one recipient block. Chromogenic in situ
hybridization assay was performed based on Chr7 centromeric
probedetection. Results: Chr 7 numerical analysis detected polysomy
(trisomy/tetrasomy) in 4/30 (13.3%) of the examined tissue OSCC cores.
Statistical significance was assessed correlating Chr7 numerical
aberrations with stage (p= 0.015), especially detected in cases not
related to human papillomavirus (HPV) (p= 0.01). Conclusion: Although
Chr7 polysomy is a relatively rare gross genetic event in OSSC, it
affects their biological behavior leading toa progressively aggressive
phenotype (advanced stage). Furthermore, Chr7 polysomy is observed more
frequently in non-viral (HPV) cases
Beam test performance of a prototype module with Short Strip ASICs for the CMS HL-LHC tracker upgrade
The Short Strip ASIC (SSA) is one of the four front-end chips designed for the upgrade of the CMS Outer Tracker for the High Luminosity LHC. Together with the Macro-Pixel ASIC (MPA) it will instrument modules containing a strip and a macro-pixel sensor stacked on top of each other. The SSA provides both full readout of the strip hit information when triggered, and, together with the MPA, correlated clusters called stubs from the two sensors for use by the CMS Level-1 (L1) trigger system. Results from the first prototype module consisting of a sensor and two SSA chips are presented. The prototype module has been characterized at the Fermilab Test Beam Facility using a 120 GeV proton beam
Beam test performance of a prototype module with Short Strip ASICs for the CMS HL-LHC tracker upgrade
International audienceThe Short Strip ASIC (SSA) is one of the four front-endchips designed for the upgrade of the CMS Outer Tracker for the HighLuminosity LHC. Together with the Macro-Pixel ASIC (MPA) it willinstrument modules containing a strip and a macro-pixel sensorstacked on top of each other. The SSA provides both full readout ofthe strip hit information when triggered, and, together with theMPA, correlated clusters called stubs from the two sensors for useby the CMS Level-1 (L1) trigger system. Results from the firstprototype module consisting of a sensor and two SSA chips arepresented. The prototype module has been characterized at theFermilab Test Beam Facility using a 120 GeV proton beam