Crisis management: operational logistics and asset visibility technologies

MBA Professional ReportThe purpose of this MBA Project was to identify and explore logistical frameworks that leverage technology to overcome problems associated with coordinated logistics operations during crisis management. Over the past ten years, there have been significant advances in RFID, satellite and other related asset visibility technologies. These advances are mature enough to significantly increase the probability of achieving a useful common operational picture during emergency response activities. Recent crisis response operations that would have benefited from improved asset visibility include the Indian Ocean tsunami, the Pakistani earthquake, Hurricane Katrina and those related to the Global War on Terror. In each of these cases, multi-agency involvement, both foreign and domestic, compounded the complexity of asset tracking and communication protocols. The establishment of a logisticstracking framework that provides adequate asset visibility, while maintaining operational security, will greatly increase the effectiveness of future crisis response operations. The proposed logistics framework serves as a viable solution for common logistical problems encountered by the U.S. and other industrialized nations while conducting crisis response operations. The framework identifies concepts, technologies and protocols that can be used to improve crisis operations on a global scale.http://archive.org/details/crisismanagement1094510122Approved for public release; distribution is unlimited

Noncanonical Self-Assembly of Highly Asymmetric Genetically Encoded Polypeptide Amphiphiles into Cylindrical Micelles

Elastin-like polypeptides (ELPs) are a class of biopolymers consisting of the pentameric repeat (VPGαG)n based on the sequence of mammalian tropoelastin that display a thermally induced soluble-to-insoluble phase transition in aqueous solution. We have discovered a remarkably simple approach to driving the spontaneous self-assembly of high molecular weight ELPs into nanostructures by genetically fusing a short 1.5 kDa (XGy)z assembly domain to one end of the ELP. Classical theories of self-assembly based on the geometric mass balance of hydrophilic and hydrophobic block copolymers suggest that these highly asymmetric polypeptides should form spherical micelles. Surprisingly, when sufficiently hydrophobic amino acids (X) are presented in a periodic sequence such as (FGG)8 or (YG)8, these highly asymmetric polypeptides self-assemble into cylindrical micelles whose length can be tuned by the sequence of the morphogenic tag. These nanostructures were characterized by light scattering, tunable resistive pulse sensing, fluorescence spectrophotometry, and thermal turbidimetry, as well as by cryogenic transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). These short assembly domains provide a facile strategy to control the size, shape, and stability of stimuli responsive polypeptide nanostructures