5 research outputs found
Successful Adoption of Children with Down Syndrome and Other Developmental Disabilities
- Author
- Barth R. P.
- Beck A. T.
- Brigid M. Cahill
- Cahill B. M.
- Cole E. S.
- Coleman J. G.
- Coyne A.
- Featherman D. L.
- Fisman S.
- Flynt S. W.
- Glidden L. M.
- Glidden L. M.
- Glidden L. M.
- Glidden L. M.
- Grotevant H. D.
- Groze V.
- Holroyd J.
- Holroyd J.
- Laraine Masters Glidden
- McCubbin H.
- Nelson K. A.
- Olson D. H.
- Patton J. R.
- Robinson N. M.
- Robinson N. M.
- Rosenthal J. A.
- Salisbury C. L.
- Salisbury C. L.
- Stoneman Z.
- Publication venue
- 'The Haworth Press'
- Publication date
- Field of study
Management Strategies for Musculoskeletal Stress in the Parents of Children with Restricted Mobility
- Author
- Anderson VP
- Calliet R
- Chartered Society of Physiotherapy
- Clinical Standards Advisory Group
- Clinical Standards Advisory Group
- Couzens-Howard D
- Cowen A
- Haslam D
- Health and Safety Commission
- Hewett S
- Hubert J
- Kinnear PR
- Lamb B
- Marshall C
- Masters-Glidden L
- Norusis MJ
- Richardson A
- Secretary of State for Health
- SPSS UK
- Stewart MJ
- Tanner MJ
- Tonkin J
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Parental coping and family stress I: Resources for and functioning of families with a preschool child having a developmental disability
- Author
- Abidin R. R.
- Bayley N.
- Blacher J.
- Bristol M. M.
- Bristol M. M.
- Cameron S. J.
- Crnic K. A.
- Friedrich W. N.
- Gallagher J. J.
- Garbow B. S.
- Gerard M. Kysela
- Hollingshead A. B.
- Jan E. Reddon
- Linda McDonald
- Mardiros M.
- MastersâGlidden L.
- McCubbin H. I.
- McCubbin H. I.
- McCubbin H. I.
- McCubbin M. A.
- McCubbin M.A.
- Skinner H. A.
- Steinhauer P.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Mnemonics in marketing: a pedagogical tool
- Author
- Barbara Wilson
- Carl E. McFarland
- Carol Carrier
- Deborah L. Best
- Debra Tolfa Veit
- Douglas L. Nelson
- E.K. Perewiznyk
- Edmund Blair Bolles
- Elizabeth Loftus
- F. Yates
- F.S. Bellezza
- F.S. Bellezza
- F.S. Bellezza
- F.S. Bellezza
- Gary R. McKenzie
- Herbert Schuman
- J.C. Marshall
- J.T. OâSullivan
- James W. Hall
- Joel R. Levin
- Joel R. Levin
- Judith L. Elliott
- K.L. Higbee
- K.L. Higbee
- Kenneth A. Blick
- Kenneth L. Higbee
- Laird S. Cermak
- Laraine Masters Glidden
- Lucy Anschutz
- M. Pressley
- M. Pressley
- M. Pressley
- M.M. Gruneberg
- M.M. Gruneberg
- M.M. Gruneberg
- Margo A. Mastropieri
- Maria M. Condus
- Michael Pressley
- N.K. Malhotra
- N.K. Malhotra
- N.K. Malhotra
- Naresh K. Malhotra
- P. Labau
- P.G. Jaffe
- Paul Gordon
- Peter E. Morris
- R.F. Carlson
- R.R. Hoffman
- R.S. Atkinson
- Richard C. Atkinson
- Richard Laufenberg
- Rossana Beni De
- Seymour Sudman
- Simon Kemp
- Thomas E. Scruggs
- W.D. Rohwer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
- Babiker A
- Babikhina K
- Back D
- Badjé A
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baggaley R
- Baghazal A
- Bagley Z
- Bah-sow O
- Baijnath P
- Bailey R
- Bailey R
- Bajos N
- Bajracharya A
- Bajunirwe F
- Bakowska E
- Bakwalufu J
- Balestre E
- Balkan S
- Balzer L
- Bamba A
- Banda G
- Banda K
- Bandason T
- Bangsberg
- Baral S
- Baral S
- Baral S
- Baral S
- Baral S
- Barasa M
- Barber M
- Barbour R
- Barde A
- Bardeguez A
- Barihuta T
- Barker C
- Barnabas R
- Barnes P
- Barnighausen T
- Baron D
- Barone M
- Barr D
- Barrenas C
- Barrington C
- Barron P
- Baruwa E
- Basar M
- Bassett I
- Bassett J
- Bassett J
- Bastos F
- Batrouney C
- Bauer G
- Baum M
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton B
- Bavinton B
- Baxter C
- Baya J
- Bazin B
- Bañón S
- Beauchamp G
- Beauchamp G
- Beck G
- Beckham S
- Bedi K
- Bekker L-G
- Beletsky L
- Belkind U
- Bell J
- Belloso W
- Belonosova E
- Belzer M
- Benedetti M
- Benfield T
- Bennett K
- Bennett K
- Bennett K
- Benson S
- Bere A
- Berkhout B
- Bermudez LG
- Bernard E
- Bernardo V
- Bernaud C
- Bertrand S
- Bhagani
- Bhardwaj K
- Bhardwaj S
- Bhardwaj S
- Bhayani L
- Bi G
- Biello K
- Biello K
- Bii S
- Bilkovski R
- Binda K
- Binley J
- Bisht M
- Bisignano A
- Bivol S
- Black D
- Blantari J
- Blick G
- Blumenthal S
- Bock N
- Boivin M
- Boleo C
- Boleo C
- Bolton-Moore C
- Bond V
- Bonnecwe C
- Bonnington O
- Bonnington O
- Bonzela J
- Boonsuk S
- Bor J
- Bor J
- Bor J
- Bor J
- Bor J
- Bor J
- Borkird T
- Borquez A
- Bose M
- Bosomprah S
- Bouchaud O
- Boulle A
- Boum Y
- Bouzas M
- Bowman B
- Boyd A
- Boyd R
- Boyer S
- Boyer S
- Boyes M
- Bozinoff N
- Bozzi G
- Bradley J
- Brahmbhatt H
- Brainard D
- Brand R
- Bredeek U
- Brenchley J
- Brennan A
- Brennan A
- Brennan A
- Brennan C
- Brennan D
- Brewster-Lee D
- Brezak A
- Brigham F
- Brigstock-Barron O
- Brill I
- Brill I
- Brittain K
- Britto P
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brooks R
- Brooks-Pollock E
- Brothers J
- Brotto L
- Brouwers P
- Brown E
- Brown G
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- Browning R
- Browning R
- Brummel S
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- Bryant H
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- BrÀu N
- Bucek A
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- Buchanan A
- Buehler S
- Bukenya D
- Bukenya D
- Bukenya D
- Bukowski L
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- Bukusi D
- Bukusi E
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- Bulterys M
- Bulya N
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- Bunu A
- Burchett S
- Burgener A
- Burke S
- Burman W
- Burmeister S
- Burton R
- Burwitz B
- Busch M
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- Busza J
- Bwakura-Dangarembizi M
- Bwakura-Dangarembizi M
- Bwana M
- Bygrave H
- Byrareddy S
- Byrd J
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- BĂ€rnighausen T
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- Cadigan J
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- Cardenas-Ochoa A
- Cardoso J
- Carias A
- Carlson J
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- Carolus G
- Carrasco M
- Carrington M
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- Carter A
- Casado J
- Casavant I
- Cassell M
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- Chabeda S
- Chakhtoura N
- Chakhtoura N
- Chakhtoura N
- Chamanga R
- Chamie G
- Chanaiwa V
- Chandawale A
- Chandra C
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- Changalucha J
- Chapman S
- Chappell E
- Charlebois E
- Charlebois E
- Charlebois E
- Charlebois E
- Charoenying S
- Charreau I
- Charreau I
- Chas J
- Chas J
- Chasanov
- Chaturvedi S
- Chaudhury S
- Chege W
- Chelbi-Alix M
- Chemhuru M
- Chen C-H
- Chen L
- Chen M
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng H
- Cheng Z
- Cheu R
- Chidiac C
- Chigayo M
- Chihana NK
- Chikandiwa A
- Chikandiwa A
- Chikonda J
- Chileshe C
- Chilima B
- Chilima B
- Chilongani J
- Chimanpure V
- Chimbetete C
- Chimbetete C
- Chime C
- Chinkonde J
- Chinsinga B
- Chipadze
- Chipeta Z
- Chipungu J
- Chirchir B
- Chirowodza A
- Chirwa E
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- Chiyaka T
- Chomba E
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- Chomchey N
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- Chopera D
- Chung A
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- Cicala C
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- Coffey-Esquivel J
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- Colebunders R
- Coletti A
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- Collins I
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- Colua E
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- Contreras D
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- Costagliola D
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- Coulibaly A
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- Crandall B
- Cranston R
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- De Gruttola V
- De Jong B
- de la Grecca R
- de Lima Pereira ME
- de Lima CE
- de Oliveira T
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- de Pedro A
- de Pokomandy A
- de Roubaix M
- de Schacht C
- de Souza M
- de Souza MB
- de Vries H
- Decker M
- Decroo T
- del Amo J
- Del Prete G
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delany-Moretlwe S
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- Delfraissy J-F
- Dellar R
- Demeri D
- Denny T
- Desbiens M
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- Devieux J
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- Deyde V
- Dezembro S
- Dezutti C
- Dhilpe V
- Dhodho M
- Di Giano L
- Dias PG
- Diergaardt C
- Diez-Martin J
- Dikgale F
- Dikobe W
- Dimba A
- Dinanga JD
- Dinapoli S
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- Dorey D
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- Dutrieux J
- Dutta A
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- Ehmer J
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- Ehrenkranz P
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated