Control and Alignment of Segmented-Mirror Telescopes: Matrices, Modes, and Error Propagation

Starting from the successful Keck telescope design, we construct and analyze the control matrix for the active control system of the primary mirror of a generalized segmented-mirror telescope, with up to 1000 segments and including an alternative sensor geometry to the one used at Keck. In particular we examine the noise propagation of the matrix and its consequences for both seeing-limited and diffraction-limited observations. The associated problem of optical alignment of such a primary mirror is also analyzed in terms of the distinct but related matrices that govern this latter problem

Nonverbal communication in health settings

The goal of the present chapter is to provide an overview of the existing literature on nonverbal communication in the medical encounter. After introducing the different functions of nonverbal behavior and its importance in the medical context, we present empirical evidence showing how physician nonverbal behavior relates to different patient outcomes such as satisfaction, trust, or adherence. We then present different models and assessment tools with which nonverbal behavior in the medical encounter can be studied. The physician's ability to pick up and correctly interpret the patient's nonverbal cues (interpersonal sensitivity) and its impact on patient outcomes will be reviewed. We close the chapter by providing a summary of the main results and an outlook on open questions in the field

Beyond "one size fits all": Physician nonverbal adaptability to patients' need for paternalism and its positive consultation outcomes

In this study, we tested whether physicians' ability to adapt their nonverbal behavior to their patients' preferences for a paternalistic interaction style is related to positive consultation outcomes. We hypothesized that the more physicians adapt their nonverbal dominance behavior to match their patients' preferences for physician paternalism, the more positive the patients perceive the medical interaction. We assessed the actual nonverbal dominance behavior of 32 general practitioners when interacting with two of their patients and compared it with each of their patients' preferences for paternalism to obtain a measure of adaptability. Additionally, we measured patient outcomes with a questionnaire assessing patient satisfaction, trust in the physician, and evaluation of physician competence. Results show that the more nonverbal dominance the physician shows towards the patient who prefers a more paternalistic physician, as compared to towards the patient who prefers a less paternalistic physician (i.e., the more the physician shows nonverbal behavioral adaptability), the more positive the consultation outcomes are. This means that physicians' ability to adapt aspects of their nonverbal dominance behavior to their individual patients' preferences is related to better outcomes for patients. As this study shows, it is advantageous for patients when a physician behaves flexibly instead of showing the same behavior towards all patients. Physician training might want to focus more on teaching a diversity of different behavior repertoires instead of a given set of behaviors

Local dependence of ion temperature gradient on magnetic configuration, rotational shear and turbulent heat flux in MAST

Experimental data from the Mega Amp Spherical Tokamak (MAST) is used to show that the inverse gradient scale length of the ion temperature R/LTi (normalized to the major radius R) has its strongest local correlation with the rotational shear and the pitch angle of the magnetic field (or, equivalently, an inverse correlation with q/{\epsilon}, the safety factor/the inverse aspect ratio). Furthermore, R/LTi is found to be inversely correlated with the gyro-Bohm-normalized local turbulent heat flux estimated from the density fluctuation level measured using a 2D Beam Emission Spectroscopy (BES) diagnostic. These results can be explained in terms of the conjecture that the turbulent system adjusts to keep R/LTi close to a certain critical value (marginal for the excitation of turbulence) determined by local equilibrium parameters (although not necessarily by linear stability).Comment: 6 pages, 3 figures, submitted to PR

Microstability analysis of pellet fuelled discharges in MAST

Reactor grade plasmas are likely to be fuelled by pellet injection. This technique transiently perturbs the profiles, driving the density profile hollow and flattening the edge temperature profile. After the pellet perturbation, the density and temperature profiles relax towards their quasi-steady-state shape. Microinstabilities influence plasma confinement and will play a role in determining the evolution of the profiles in pellet fuelled plasmas. In this paper we present the microstability analysis of pellet fuelled H-mode MAST plasmas. Taking advantage of the unique capabilities of the MAST Thomson scattering system and the possibility of synchronizing the eight lasers with the pellet injection, we were able to measure the evolution of the post-pellet electron density and temperature profiles with high temporal and spatial resolution. These profiles, together with ion temperature profiles measured using a charge exchange diagnostic, were used to produce equilibria suitable for microstability analysis of the equilibrium changes induced by pellet injection. This analysis, carried out using the local gyrokinetic code GS2, reveals that the microstability properties are extremely sensitive to the rapid and large transient excursions of the density and temperature profiles, which also change collisionality and beta e significantly in the region most strongly affected by the pellet ablation.Comment: 21 pages, 10 figures. This is an author-created, un-copyedited version of an article submitted for publication in Plasma Physics and Controlled Fusion. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from i

The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ

<p>Abstract</p> <p>Background</p> <p>The signal transduction cascade operational in the vomeronasal organ (VNO) of the olfactory system detects odorants important for prey localization, mating, and social recognition. While the protein machinery transducing these external cues has been individually well characterized, little attention has been paid to the role of protein-protein interactions among these molecules. Development of an <it>in vitro </it>expression system for the transient receptor potential 2 channel (TRPC2), which establishes the first electrical signal in the pheromone transduction pathway, led to the discovery of two protein partners that couple with the channel in the native VNO.</p> <p>Results</p> <p>Homer family proteins were expressed in both male and female adult VNO, particularly Homer 1b/c and Homer 3. In addition to this family of scaffolding proteins, the chaperones receptor transporting protein 1 (RTP1) and receptor expression enhancing protein 1 (REEP1) were also expressed. RTP1 was localized broadly across the VNO sensory epithelium, goblet cells, and the soft palate. Both Homer and RTP1 formed protein-protein interactions with TRPC2 in native reciprocal pull-down assays and RTP1 increased surface expression of TRPC2 in <it>in vitro </it>assays. The RTP1-dependent TRPC2 surface expression was paralleled with an increase in ATP-stimulated whole-cell current in an <it>in vitro </it>patch-clamp electrophysiological assay.</p> <p>Conclusions</p> <p>TRPC2 expression and channel activity is regulated by chaperone- and scaffolding-associated proteins, which could modulate the transduction of chemosignals. The developed <it>in vitro </it>expression system, as described here, will be advantageous for detailed investigations into TRPC2 channel activity and cell signalling, for a channel protein that was traditionally difficult to physiologically assess.</p