936 research outputs found
The Determinants of Student Effort at Learning ERP: A Cultural Perspective
This paper develops a research model based on the Unified Theory of Acceptance and Use of Technology model (UTAUT) and Hofstede’s cultural dimensions to explore factors that influence student effort at learning Enterprise Resource Planning (ERP) systems. A Structural Equation Model (SEM) using LISREL was utilized to validate the proposed research model using a convenience sample of students at two universities in the USA. The results showed that while subjective norm and career relevance were positively associated with performance expectancy (PE), course structure and self-efficacy were positively associated with effort expectancy (EE). Performance expectancy and effort expectancy were positively associated with student attitude toward ERP. Student attitude toward ERP was positively associated with student effort at learning ERP. The results also revealed that power distance, uncertainty avoidance, and masculinity moderate the relationships between EE and PE on one side and attitude on the other side, between EE and PE, and between attitude and effort at learning ERP, respectively. Implications for educators and researchers are reported
The Mechanism and Potential Therapeutic Effects of Cyclosporin, Cyclophilin, Probiotics and Syndecan-1 in an Animal Model of Inflammatory Bowel Disease
Background: Inflammatory bowel diseases (IBDs) have several treatment modalities including immunoregulators, like cyclosporine A, an immunosuppressant that interacts with cytoplasmic cyclophilin A, and probiotics. Aims: This study explored and compared the possible role of syndecan-1 in the IBD pathogenic process as well as the effectiveness of cyclophilin A, cyclosporine A, and their combination in the management of IBDs in the presence of probiotics. Methodology: IBD was induced in a total of 112 mice equally divided between syndecan-1 knock-out (KO) and Balb/c wild-type mice, using 2% dextran sulfate sodium (DSS) followed by intraperitoneal treatment with cyclosporine A, cyclophilin A, or a combination of both. In addition, a daily dose of probiotics was given in their drinking water. The animals were monitored for clinical signs and symptoms and checked for gross pathologies in the abdomen after 3 weeks. Descending and sigmoid colon biopsies were collected and fixed for routine microscopy or frozen for protein extraction and molecular testing for IL-6, CD3, CD147, and beta 1 integrins as well as pAkt expression. Results: The data showed that the induction of IBD in the syndecan-1 KO mice was more severe at the clinical, histological, and molecular levels than in the wild type. The combined CypA-CyA treatment showed no added inhibitory effect compared to single-drug treatment in both strains. Probiotics added to the combination was more effective in the wild type and, when used alone, its inhibition of IL-6 was the highest. As for the CD147 marker, there were more suppressions across the various groups in the KO mice except for the probiotics-alone group. Concerning CD3, it was significantly increased by the CypA-CyA complex, which led to more inflammation in the KO mice. Probiotics had little effect with the combination. In relation to beta 1 integrins, the CypA-CyA combination made no significant difference from CyA alone, and adding probiotics to the combination resulted in higher beta 1 integrin expression in the KO mice. As for pAkt, it was very well expressed and upregulated in both strains treated with DSS, but the effect was much larger in the KO mice. In brief, the CypA-CyA complex showed a decrease in the expression of pAkt, but there was no added effect of both drugs. Probiotics along with the complex had a similar reduction effects in both strains, with a greater effect in the wild-type mice, while probiotics alone led to a similar reduction in pAkt expressions in both strains. Conclusions: The differential effects of CyA, CypA, probiotics, and their combinations on the various inflammatory markers, as well as the histological alterations and clinical signs and symptoms, speak in favor of a clear role of syndecan-1 in reducing inflammation. However, probiotics need to be considered after more explorations into the mechanisms involved in the presence of CypA and CyA especially since pAkt is less active in their presence
Aging in Dense Colloids as Diffusion in the Logarithm of Time
The far-from-equilibrium dynamics of glassy systems share important
phenomenological traits. A transition is generally observed from a
time-homogeneous dynamical regime to an aging regime where physical changes
occur intermittently and, on average, at a decreasing rate. It has been
suggested that a global change of the independent time variable to its
logarithm may render the aging dynamics homogeneous: for colloids, this entails
diffusion but on a logarithmic time scale. Our novel analysis of experimental
colloid data confirms that the mean square displacement grows linearly in time
at low densities and shows that it grows linearly in the logarithm of time at
high densities. Correspondingly, pairs of particles initially in close contact
survive as pairs with a probability which decays exponentially in either time
or its logarithm. The form of the Probability Density Function of the
displacements shows that long-ranged spatial correlations are very long-lived
in dense colloids. A phenomenological stochastic model is then introduced which
relies on the growth and collapse of strongly correlated clusters ("dynamic
heterogeneity"), and which reproduces the full spectrum of observed colloidal
behaviors depending on the form assumed for the probability that a cluster
collapses during a Monte Carlo update. In the limit where large clusters
dominate, the collapse rate is ~1/t, implying a homogeneous, log-Poissonian
process that qualitatively reproduces the experimental results for dense
colloids. Finally an analytical toy-model is discussed to elucidate the strong
dependence of the simulation results on the integrability (or lack thereof) of
the cluster collapse probability function.Comment: 6 pages, extensively revised, final version; for related work, see
http://www.physics.emory.edu/faculty/boettcher/ or
http://www.fysik.sdu.dk/staff/staff-vip/pas-personal.htm
Adaptive service binding with lightweight semantic web services
[About the book]:
Service-oriented systems are increasingly challenging traditional software engineering approaches including distribution, componentization, composition, requirements, specification, verification, and evolution. Continuous mutual impact between service-oriented computing and software engineering has been seen in the last decade, and can increasingly be witnessed. The book aims to introduce the state-of-the-art service engineering methods and on-going research efforts from the perspective of research results elaborated in European research projects. Essential problems such as service specification and service composition are addressed by innovative approaches. Emerging requirements of adaptive service and pervasive service are met with new infrastructures. The book provides an integrated vision of the most important research directions in service engineering. This book is intended for scientists to be inspired with new ideas, for researchers new to the exciting field of service engineering and provides a consolidated overview on service engineering, thus supporting practitioners to facilitate their service-oriented architectures
Tracing the Evolution of Temperature in Near Fermi Energy Heavy Ion Collisions
The kinetic energy variation of emitted light clusters has been employed as a
clock to explore the time evolution of the temperature for thermalizing
composite systems produced in the reactions of 26A, 35A and 47A MeV Zn
with Ni, Mo and Au. For each system investigated, the
double isotope ratio temperature curve exhibits a high maximum apparent
temperature, in the range of 10-25 MeV, at high ejectile velocity. These
maximum values increase with increasing projectile energy and decrease with
increasing target mass. The time at which the maximum in the temperature curve
is reached ranges from 80 to 130 fm/c after contact. For each different target,
the subsequent cooling curves for all three projectile energies are quite
similar. Temperatures comparable to those of limiting temperature systematics
are reached 30 to 40 fm/c after the times corresponding to the maxima, at a
time when AMD-V transport model calculations predict entry into the final
evaporative or fragmentation stage of de-excitation of the hot composite
systems. Evidence for the establishment of thermal and chemical equilibrium is
discussed.Comment: 9 pages, 5 figure
The Physics of the Colloidal Glass Transition
As one increases the concentration of a colloidal suspension, the system
exhibits a dramatic increase in viscosity. Structurally, the system resembles a
liquid, yet motions within the suspension are slow enough that it can be
considered essentially frozen. This kinetic arrest is the colloidal glass
transition. For several decades, colloids have served as a valuable model
system for understanding the glass transition in molecular systems. The spatial
and temporal scales involved allow these systems to be studied by a wide
variety of experimental techniques. The focus of this review is the current
state of understanding of the colloidal glass transition. A brief introduction
is given to important experimental techniques used to study the glass
transition in colloids. We describe features of colloidal systems near and in
glassy states, including tremendous increases in viscosity and relaxation
times, dynamical heterogeneity, and ageing, among others. We also compare and
contrast the glass transition in colloids to that in molecular liquids. Other
glassy systems are briefly discussed, as well as recently developed synthesis
techniques that will keep these systems rich with interesting physics for years
to come.Comment: 56 pages, 18 figures, Revie
Towards the critical behavior for the light nuclei by NIMROD detector
The critical behavior for the light nuclei with A has been
investigated experimentally by the NIMROD multi-detectors. The wide variety of
observables indicate the critical point has been reached in the disassembly of
hot nuclei at an excitation energy of 5.60.5 MeV/u.Comment: 4 pages, 2 figures; Proceeding of 18th Nuclear Physics Division
Conference of the Euro. Phys. Society (NPDC18) "Phase transitions in strongly
interacting matter", Prague, 23.8.-29.8. 2004. To be published in Nuclear
Physics
Evidence of Critical Behavior in the Disassembly of Nuclei with A ~ 36
A wide variety of observables indicate that maximal fluctuations in the
disassembly of hot nuclei with A ~ 36 occur at an excitation energy of 5.6 +-
0.5 MeV/u and temperature of 8.3 +- 0.5 MeV. Associated with this point of
maximal fluctuations are a number of quantitative indicators of apparent
critical behavior. The associated caloric curve does not appear to show a
flattening such as that seen for heavier systems. This suggests that, in
contrast to similar signals seen for liquid-gas transitions in heavier nuclei,
the observed behavior in these very light nuclei is associated with a
transition much closer to the critical point.Comment: v2: Major changes, new model calculations, new figure
A Ghoshal-like Test of Equilibration in Near-Fermi-Energy Heavy Ion Collisions
Calorimetric and coalescence techniques have been employed to probe
equilibration for hot nuclei produced in heavy ion collisions of 35 to 55 MeV/u
projectiles with medium mass targets. Entrance channel mass asymmetries and
energies were selected in order that very hot composite nuclei of similar mass
and excitation would remain after early stage pre-equilibrium particle
emission. Inter-comparison of the properties and de-excitation patterns for
these different systems provides evidence for the production of hot nuclei with
decay patterns relatively independent of the specific entrance channel.Comment: 7 pages, 2 figure
Critical Behavior in Light Nuclear Systems: Experimental Aspects
An extensive experimental survey of the features of the disassembly of a
small quasi-projectile system with 36, produced in the reactions of 47
MeV/nucleon Ar + Al, Ti and Ni, has been carried
out. Nuclei in the excitation energy range of 1-9 MeV/u have been investigated
employing a new method to reconstruct the quasi-projectile source. At an
excitation energy 5.6 MeV/nucleon many observables indicate the presence
of maximal fluctuations in the de-excitation processes. The fragment
topological structure shows that the rank sorted fragments obey Zipf's law at
the point of largest fluctuations providing another indication of a liquid gas
phase transition. The caloric curve for this system shows a monotonic increase
of temperature with excitation energy and no apparent plateau. The temperature
at the point of maximal fluctuations is MeV. Taking this
temperature as the critical temperature and employing the caloric curve
information we have extracted the critical exponents , and
from the data. Their values are also consistent with the values of the
universality class of the liquid gas phase transition. Taken together, this
body of evidence strongly suggests a phase change in an equilibrated mesoscopic
system at, or extremely close to, the critical point.Comment: Physical Review C, in press; some discussions about the validity of
excitation energy in peripheral collisions have been added; 24 pages and 32
figures; longer abstract in the preprin
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