2,976 research outputs found
Mixing Improvement in a T-Shaped Micro-Junction through Small Rectangular Cavities
The T-shaped micro-junction is among the most used geometry in microfluidic applications, and many design modifications of the channel walls have been proposed to enhance mixing. In this work, we investigate through numerical simulations the introduction of one pair of small rectangular cavities in the lateral walls of the mixing channel just downstream of the confluence region. The aim is to preserve the simple geometry that has contributed to spread the practical use of the T-shaped micro-junction while suggesting a modification that should, in principle, work jointly with the vortical structures present in the mixing channel, further enhancing their efficiency in mixing without significant additional pressure drops. The performance is analyzed in the different flow regimes occurring by increasing the Reynolds number. The cavities are effective in the two highly-mixed flow regimes, viz., the steady engulfment and the periodic asymmetric regimes. This presence does not interfere with the formation of the vortical structures that promote mixing by convection in these two regimes, but it further enhances the mixing of the inlet streams in the near-wall region of the mixing channel without any additional cost, leading to better performance than the classical configuration
Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men
The stimulatory effects of testosterone on erythropoiesis are very well known, but the mechanisms underlying the erythropoietic action of testosterone are still poorly understood, although erythropoietin has long been considered a potential mediator. A total of 108 healthy men >65 years old with serum testosterone concentration <475 ng/dL were recruited by direct mailings to alumni of the University of Pennsylvania and Temple University, and randomized to receive a 60-cm(2) testosterone or placebo patch for 36 months. Ninety-six subjects completed the trial. We used information and stored serum specimens from this trial to test the hypothesis that increasing testosterone increases haemoglobin by stimulating erythropoietin production. We used information of 67 men, 43 in the testosterone group and 24 in the placebo group who had banked specimens available for assays of testosterone, haemoglobin and erythropoietin at baseline and after 36 months. The original randomized clinical study was primarily designed to verify the effects of testosterone on bone mineral density. The primary outcome of this report was to investigate whether or not transdermal testosterone increases haemoglobin by increasing erythropoietin levels. The mean age +/- SD of the 67 subjects at baseline was 71.8 +/- 4.9 years. Testosterone replacement therapy for 36 months, as compared with placebo, induced a significant increase in haemoglobin (0.86 +/- 0.31 g/dL, p = 0.01), but no change in erythropoietin levels (-0.24 +/- 2.16 mIU/mL, p = 0.91). Included time-varying measure of erythropoietin did not significantly account for the effect of testosterone on haemoglobin (Treatment-by-time: beta = 0.93, SE = 0.33, p = 0.01). No serious adverse effect was observed. Transdermal testosterone treatment of older men for 36 months significantly increased haemoglobin, but not erythropoietin levels. The haematopoietic effect of testosterone does not appear to be mediated by stimulation of erythropoietin production
Exploring improved holographic theories for QCD: Part II
This paper is a continuation of ArXiv:0707.1324 where improved holographic
theories for QCD were set up and explored. Here, the IR confining geometries
are classified and analyzed. They all end in a "good" (repulsive) singularity
in the IR. The glueball spectra are gaped and discrete, and they favorably
compare to the lattice data. Quite generally, confinement and discrete spectra
imply each other. Asymptotically linear glueball masses can also be achieved.
Asymptotic mass ratios of various glueballs with different spin also turn out
to be universal. Mesons dynamics is implemented via space filling D4-anti-D4
brane pairs. The associated tachyon dynamics is analyzed and chiral symmetry
breaking is shown. The dynamics of the RR axion is analyzed, and the
non-perturbative running of the QCD theta-angle is obtained. It is shown to
always vanish in the IR.Comment: 65+18 pages, 20 figures (v3) Some modifications in Appendix E
explaining in more detail the issue of initial conditions; typos corrected.
Published versio
Use of barbed suture without fashioning the “classical” Wirsung-jejunostomy in a modified end-to-side robotic pancreatojejunostomy
Background: The treatment of the pancreatic stump is a critical step of pancreatoduodenectomy (PD). Robot-assisted surgery (RAS) can facilitate minimally invasive challenging abdominal procedures, including pancreatojejunostomy. However, one of the major limitations of RAS stems from its lack of tactile feedback that can lead to pancreatic parenchyma laceration during knot tying or during traction on the suture. Moreover, a Wirsung-jejunostomy is not always easy to execute, especially in cases with small diameter duct. Herein, we describe and video-report the technical details of a robotic modified end-to-side invaginated robotic pancreatojejunostomy (RmPJ) with the use of barbed suture instead of the “classical” Wirsung-jejunostomy. Methods: The RmPJ technique consists of a double layer of absorbable monofilament running barbed suture (3–0 V-Loc), the outer layer is used to invaginate the pancreatic stump. Thereafter, a small enterotomy is made in the jejunum exactly opposite to the location of the pancreatic duct for stent insertion (usually 5 Fr) inside the duct. The internal layer provides a second barbed running suture placed between the pancreatic capsule/parenchyma and the jejunal seromuscular layer. Results: A total of 14 patients underwent robotic PD with RmPJ at our Institution. The mean console time was (281.36 ± 31.50 min), while the mean operative time for fashioning the RmPJ was 37.31 ± 7.80 min. Ten out of 14 patients were discharged within postoperative day 8. No clinically relevant pancreatic fistulas were encountered, while two patients developed biochemical leaks. Conclusions: RmPJ is feasible and reproducible irrespective of pancreatic duct size and parenchyma, and can enhance the surgical workflow of this operation. Specifically, the use of barbed sutures allows the exploitation of the potential advantages of the RAS, while minimizing the negative effect caused by the main disadvantage of the robotic approach, its absence of tactile feedback, by ensuring uniform tension on the continuous suture lines used, especially during the reconstructive phase of the operation
Study of dimuon production in Indium-Indium collisions with the NA60 experiment
The NA60 experiment at the CERN-SPS is devoted to the study of dimuon
production in heavy-ion and proton-nucleus collisions. We present preliminary
results from the analysis of Indium-Indium collisions at 158 GeV per nucleon.
The topics covered are low mass vector meson production, J/psi production and
suppression, and the feasibility of the open charm measurement from the dimuon
continuum in the mass range below the J/psi peak.Comment: Contribution at XXXXth Rencontres de Moriond, "QCD and High Energy
Hadronic Interactions
First results from the NA60 experiment at CERN
Since 1986, several heavy ion experiments have studied some signatures of the
formation of the quark-gluon plasma and a few exciting results have been found.
However, some important questions are still unanswered and require new
measurements. The NA60 experiment, with a new detector concept that vastly
improves dimuon detection in proton-nucleus and heavy-ion collisions, studies
several of those open questions, including the production of open charm. This
paper presents the experiment and some first results from data collected in
2002.Comment: Paper presented at the XXXVIII Rencontres de Moriond, QCD and High
Energy Hadronic Interactions, Les Arcs, March 22-29, 2003. 4 pages, 6 figure
Positive Parity Scalar Mesons in the 1-2 GeV Mass Range
Based on the observation that K_0(1430) is lighter than its SU_3 counterpart,
a_0(1450), we examine the possibility that these particles, together with
f_0(1370), f_0(1500) and f_0(1710), fill a tetraquark recurrence of the sub-GeV
0^{++} nonet mixed with a glueball state. We find the picture to be consistent
with the known data about the three f_0 resonances, more than the q-qbar
hypothesis. Conventional spin-orbit coupling suggests the q-qbar, P-wave, nonet
to lie around 1200 MeV. We review possible experimental indications of a scalar
isovector resonance at 1.29 GeV, first observed by OBELIX in p-pbar
annihilation.Comment: 12 pages, 9 figures. Extended version. References added. Results and
conclusions unchange
Meson Production in In-In Collisions and the Puzzle
The NA60 experiment measured dimuon production in In-In collisions at 158
AGeV. This paper presents a high statistics measurement of with
the specific objective to provide insight on the puzzle, i.e. the
difference in the inverse slopes and absolute yields measured by NA49 and
NA50 in the kaon and lepton channel, respectively. Transverse momentum
distributions were studied as a function of centrality. The slope parameter
shows a rapid increase with centrality, followed by a saturation. Variations of
with the fit range of the order of 15 MeV were observed, possibly as a
consequence of radial flow. The meson yield normalized to the number of
participants increases with centrality and is consistently higher than the
yield measured by the NA49 experiment at any centrality.Comment: 4 Pages, 2 Figures. Proceedings of the 20 International
Conference on Ultra-Relativistic Nucleus Nucleus Collision
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