25 research outputs found
Dynamic regime of ignition of solid propellant
This article presents a dynamic regime of exposure of the radiant flux on the sample of gun-cotton. Obtained time the ignition of gun-cotton in the heating conditions of increasing heat flux in the range from 0.2 W/cm2 to 22 W/cm2. A comparison of the delay times of the ignition when heated variable and constant heat flux
Investigation of working processes in a flowing channel of ramjet engine
The technique and results of experimental-theoretical study of gas-dynamics, heat transfer and the structure of gas-flow in the flowing channel of a ramjet engine in Mach number range M = (5-7) are presented. The temperature distribution along the flowing channel of a ramjet engine was experimentally obtained. The temperature along the wall of the flowing channel of the axisymmetric model was measured using the developed thermoprobe. Distributions of Mach number and temperature along the symmetry axis of the flowing channel of the model are obtained numerically. Comparison of the numerical and experimentally obtained values of the Mach number showed their qualitative agreement
Toolbox model of evolution of metabolic pathways on networks of arbitrary topology
In prokaryotic genomes the number of transcriptional regulators is known to
quadratically scale with the total number of protein-coding genes. Toolbox
model was recently proposed to explain this scaling for metabolic enzymes and
their regulators. According to its rules the metabolic network of an organism
evolves by horizontal transfer of pathways from other species. These pathways
are part of a larger "universal" network formed by the union of all
species-specific networks. It remained to be understood, however, how the
topological properties of this universal network influence the scaling law of
functional content of genomes. In this study we answer this question by first
analyzing the scaling properties of the toolbox model on arbitrary tree-like
universal networks. We mathematically prove that the critical branching
topology, in which the average number of upstream neighbors of a node is equal
to one, is both necessary and sufficient for the quadratic scaling. Conversely,
the toolbox model on trees with exponentially expanding, supercritical topology
is characterized by the linear scaling with logarithmic corrections. We further
generalize our model to include reactions with multiple substrates/products as
well as branched or cyclic metabolic pathways. Unlike the original model the
new version employs evolutionary optimized pathways with the smallest number of
reactions necessary to achieve their metabolic tasks. Numerical simulations of
this most realistic model on the universal network from the KEGG database again
produced approximately quadratic scaling. Our results demonstrate why, in spite
of their "small-world" topology, real-life metabolic networks are characterized
by a broad distribution of pathway lengths and sizes of metabolic regulons in
regulatory networks.Comment: 34 pages, 9 figures, 2 table
Mathematical modelling of the liquid atomization process by cocurrent gas flow
This paper focuses on the physical-mathematical model of liquid atomization in the spray pattern of an ejection nozzle. A flow field of a gas phase behind the nozzle section is computed using the Ansys Fluent package. Dynamics of molten metal droplets in the gas phase within a trajectory approach is calculated. Using the presented model, numerical calculation results are given
Instability of coherent states of a real scalar field
We investigate stability of both localized time-periodic coherent states
(pulsons) and uniformly distributed coherent states (oscillating condensate) of
a real scalar field satisfying the Klein-Gordon equation with a logarithmic
nonlinearity. The linear analysis of time-dependent parts of perturbations
leads to the Hill equation with a singular coefficient. To evaluate the
characteristic exponent we extend the Lindemann-Stieltjes method, usually
applied to the Mathieu and Lame equations, to the case that the periodic
coefficient in the general Hill equation is an unbounded function of time. As a
result, we derive the formula for the characteristic exponent and calculate the
stability-instability chart. Then we analyze the spatial structure of the
perturbations. Using these results we show that the pulsons of any amplitudes,
remaining well-localized objects, lose their coherence with time. This means
that, strictly speaking, all pulsons of the model considered are unstable.
Nevertheless, for the nodeless pulsons the rate of the coherence breaking in
narrow ranges of amplitudes is found to be very small, so that such pulsons can
be long-lived. Further, we use the obtaned stability-instability chart to
examine the Affleck-Dine type condensate. We conclude the oscillating
condensate can decay into an ensemble of the nodeless pulsons.Comment: 11 pages, 8 figures, submitted to Physical Review
Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response
Dramatic rise of mutators has been found to accompany adaptation of bacteria
in response to many kinds of stress. Two views on the evolutionary origin of
this phenomenon emerged: the pleiotropic hypothesis positing that it is a
byproduct of environmental stress or other specific stress response mechanisms
and the second order selection which states that mutators hitchhike to fixation
with unrelated beneficial alleles. Conventional population genetics models
could not fully resolve this controversy because they are based on certain
assumptions about fitness landscape. Here we address this problem using a
microscopic multiscale model, which couples physically realistic molecular
descriptions of proteins and their interactions with population genetics of
carrier organisms without assuming any a priori fitness landscape. We found
that both pleiotropy and second order selection play a crucial role at
different stages of adaptation: the supply of mutators is provided through
destabilization of error correction complexes or fluctuations of production
levels of prototypic mismatch repair proteins (pleiotropic effects), while rise
and fixation of mutators occur when there is a sufficient supply of beneficial
mutations in replication-controlling genes. This general mechanism assures a
robust and reliable adaptation of organisms to unforeseen challenges. This
study highlights physical principles underlying physical biological mechanisms
of stress response and adaptation