10 research outputs found
Federation of Infectious Diseases Societies of Southern Africa guideline : recommendations for the detection, management and prevention of healthcare-associated Candida auris colonisation and disease in South Africa
Candida auris has been detected at almost 100 South African hospitals, causing large
outbreaks in some facilities, and this pathogen now accounts for approximately 1 in 10 cases
of candidaemia. The objective of this guideline is to provide updated, evidence-informed
recommendations outlining a best-practice approach to prevent, diagnose and manage
C. auris disease in public- and private-sector healthcare settings in South Africa. The 18
practical recommendations cover five focus areas: laboratory identification and antifungal
susceptibility testing, surveillance and outbreak response, infection prevention and control,
clinical management and antifungal stewardship.The South African Society for Clinical Microbiology and the Federation of Infectious Diseases Societies of Southern Africa.https://sajid.co.za/index.php/sajidpm2020School of Health Systems and Public Health (SHSPH
L'ADHESION THERAPEUTIQUE (CAS PARTICULIER DU SUJET INFECTE PAR LE VIH)
PARIS-BIUM (751062103) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocSudocFranceF
Long-Term Central Venous Catheter Infection in HIV-infected and Cancer Patients: A Multicenter Cohort Study
Prospective evaluation of risk factors of cutaneous drug reactions to sulfonamides in patients with AIDS
Detection of a SARS-CoV-2 variant of concern in South Africa
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3,4,5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZuluâNatal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic dataâwhich show rapid expansion and displacement of other lineages in several regionsâsuggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6,7,8