Theoretical and methodical essence of technology transfer on the basis of entreprenry and intrapreneurship

In the article it is proved that a considerable part of scientific developments of industrial enterprises, in most cases quite effective and promising, remain unclaimed; high, and in most cases inaccessible even to the technological product development companies themselves. their commercialization (transfer) costs are not high enough, and in most cases not accessible even to the technological product development companies themselves. The conceptual and categorical apparatus of technology transfer has been clarified. It is proved that transfer of technologies developed at machine-building enterprises can be carried out mainly with the use of two entrepreneurial institutions: entrepreneurship (external transfer) and intrapreneurship (intra-firm transfer). Possible organizational and economic forms of the end result have been formed when used in machine-building enterprises of entreprenry and intrapreneurship. The basic prerequisites for the formation and use of integrated high technologies at machine-building enterprises, which most closely meet the economic and legal criteria of the transfer process. Such prerequisites, in particular, include: increase in the scientific and technological capacity, complication of engineering products, acceleration of scientific and technological progress, introduction of intellectual development in the production, increasing the level of market competition, etc. A detailed analysis of the current state of the domestic technological market has been carried out, and the main positive and negative factors have been identified, which most or not ensure the effectiveness of its functioning. It was found that the level of financial support for innovative activity in the country (0.3-0.4% of GDP) is not able to ensure the effectiveness of scientific research. Obstacles to the effective implementation of intra-company technology transfer at machinebuilding enterprises are identified and generalized. These include economic, scientific, technical, social and political obstacles

Current state and prospects of development of the tractors market in Ukraine

The article contains a detailed analysis of the current state and prospects for the development of the production of tractor equipment in Ukraine. The marketing characteristics of the tractors market in Ukraine and the Russian Federation are considered. The technical and economic indicators of the work of the leading Ukrainian manufacturers of tractor equipment are investigated. In particular, the authors studied in detail the development prospects of the Kharkov Tractor Plant.Based on the research carried out by the authors, a number of innovative measures are proposed, the implementation of which can lead to a drastic change in the market condition of domestic tractor construction. These proposals are mainly related to the state and legislative support of tractor-building at the national and regional levels and can be summarized as follows

Intra-firm technology transfer as a factor of sustainable development of industrial enterprises

Technological processes of machine-building enterprises are quite specific, characteristic only for this sector and are virtually absent from all the others. In recent times, scientists and developers of technology products in the engineering industry increasingly focused on development of unconventional technologies, the possibility of the development of which is based on significant achievements in fundamental and applied research

Structure, optical, electrical and thermoelectric properties of solution-processed Li-doped NiO films grown by SILAR

The article presents a new facial synthesis of Li-doped NiO films (NiO:Li) via an easy and cost-effective method Successive Ionic Layer Adsorption and Reaction (SILAR) with the processing of the obtained NiO films in a lithium-containing aqueous solution for their transformation after annealing into NiO:Li layers. Comparative analysis of crystal structure, optical, electrical and thermoelectric properties of the obtained NiO and NiO:Li 420-1050 nm thick films have reveiled a cubic rock-salt NiO structure, at that, NiO:Li samples are nanocrystalline single phased Li-NiO solid solutions. The fabricated NiO and NiO:Li films are p-type semiconductors with activation energy Ea = 0.1 eV and Ea = 0.25‒0.31 eV, respectively. The obtained in-plane Seebeck coefficients Z are in the range 0.20–0.33 mV/К. Notwithstanding the fact that the maximum values of the thermoelectric power factors P=2.2 μW/K2·m, are rather small, they were achieved if the hot end of the NiO:Li film was heated only to 115 °C. Thus, the produced in this work new low cost thermoelectric thin film material is suitable for a production of electrical energy for low-power devices due to absorption of low-potential heat

Overturning established chemoselectivities : selective reduction of arenes over malonates and cyanoacetates by photoactivated organic electron donors

The prevalence of metal-based reducing reagents, including metals, metal complexes, and metal salts, has produced an empirical order of reactivity that governs our approach to chemical synthesis. However, this reactivity may be influenced by stabilization of transition states, intermediates, and products through substrate-metal bonding. This article reports that in the absence of such stabilizing interactions, established chemoselectivities can be overthrown. Thus, photoactivation of the recently developed neutral organic superelectron donor 5 selectively reduces alkyl-substituted benzene rings in the presence of activated esters and nitriles, in direct contrast to metal-based reductions, opening a new perspective on reactivity. The altered outcomes arising from the organic electron donors are attributed to selective interactions between the neutral organic donors and the arene rings of the substrates

A phase 1b/2b multicenter study of oral panobinostat plus azacitidine in adults with MDS, CMML or AML with less than or equal to 30% blasts

Treatment with azacitidine (AZA), a demethylating agent, prolonged overall survival (OS) vs conventional care in patients with higher-risk myelodysplastic syndromes (MDS). As median survival with monotherapy is <2 years, novel agents are needed to improve outcomes. This phase 1b/2b trial (n=113) was designed to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of panobinostat (PAN)+AZA (phase 1b) and evaluate the early efficacy and safety of PAN+AZA vs AZA monotherapy (phase 2b) in patients with higher-risk MDS, chronic myelomonocytic leukemia or oligoblastic acute myeloid leukemia with <30% blasts. The MTD was not reached; the RP2D was PAN 30 mg plus AZA 75 mg/m2. More patients receiving PAN+AZA achieved a composite complete response ([CR)+morphologic CR with incomplete blood count+bone marrow CR (27.5% (95% CI, 14.6–43.9%)) vs AZA (14.3% (5.4–28.5%)). However, no significant difference was observed in the 1-year OS rate (PAN+AZA, 60% (50–80%); AZA, 70% (50–80%)) or time to progression (PAN+AZA, 70% (40–90%); AZA, 70% (40–80%)). More grade 3/4 adverse events (97.4 vs 81.0%) and on-treatment deaths (13.2 vs 4.8%) occurred with PAN+AZA. Further dose or schedule optimization may improve the risk/benefit profile of this regimen

Analogue peptides for the immunotherapy of human acute myeloid leukemia

Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies

ГИГАНТСКИЕ ХОНДРОМЫ ЛЕГКОГО КАК ПРОЯВЛЕНИЕ ТРИАДЫ КАРНЕЯ

Carney’s triad is a rare syndrome, comprising of the GIST of the stomach, functioning extra-adrenal paraganglioma and pulmonary chondroma. We present a case of a young woman diagnosed with gastric GIST, mesenteric  paraganglioma and two giant chondromas of the left lung. Due to the rapid growth of pulmonary neoplasms and  their potential malignant behaviour, the left pneumonectomy was performed.Триада Карнея — редкий синдром, характеризующийся сочетанием гастроинтестинальной стромальной опухоли (ГИСО) желудка, функционирующей экстраадренальной параганглиомы и легочной хондромы. Мы представляем случай наличия у пациентки ГИСО желудка, экстрадреналовой параганглиомы и двух гигантских хондром левого легкого. В  связи с быстрым ростом образований легкого и невозможностью исключить их  злокачественный характер, пациентке была выполнена левосторонняя пневмонэктомия