A multidirectional modified Physarum solver for discrete decision making

In this paper, a bio-inspired algorithm able to incrementally grow decision graphs in multiple directions is presented. The heuristic draws inspiration from the behaviour of the slime mould Physarum Polycephalum. In its main vegetative state, the plasmodium, this large single-celled amoeboid organism extends and optimizes a net of veins looking for food. The algorithm is here used to solve classical problems in operations research (symmetric Traveling Salesman and Vehicle Routing Problems). Simulations on selected test cases demonstrate that a multidirectional modied Physarum solver performs better than a unidirectional one. The ability to evaluate decisions from multiple directions enhances the performance of the solver in the construction and selection of optimal decision sequences

Optimal multi-objective discrete decision making using a multidirectional modified Physarum solver

This paper will address a bio-inspired algorithm able to incrementally grow decision graphs in multiple directions for discrete multi-objective optimization. The algorithm takes inspiration from the slime mould Physarum Polycephalum, an amoeboid organism that in its plasmodium state extends and optimizes a net of veins looking for food. The algorithm is here used to solve multi-objective Traveling Salesman and Vehicle Routing Problems selected as representative examples of multi-objective discrete decision making problems. Simulations on selected test case showed that building decision sequences in two directions and adding a matching ability (multidirectional approach) is an advantageous choice if compared with the choice of building decision sequences in only one direction (unidirectional approach). The ability to evaluate decisions from multiple directions enhances the performance of the solver in the construction and selection of optimal decision sequences

A standard-driven communication protocol for disconnected clinics in rural areas

The importance of the Electronic Health Record (EHR), which stores all healthcare-related data belonging to a patient, has been recognized in recent years by governments, institutions, and industry. Initiatives like Integrating the Healthcare Enterprise (IHE) have been developed for the definition of standard methodologies for secure and interoperable EHR exchanges among clinics and hospitals. Using the requisites specified by these initiatives, many large-scale projects have been set up to enable healthcare professionals to handle patients' EHRs. Applications deployed in these settings are often considered safety-critical, thus ensuring such security properties as confidentiality, authentication, and authorization is crucial for their success. In this paper, we propose a communication protocol, based on the IHE specifications, for authenticating healthcare professionals and assuring patients' safety in settings where no network connection is available, such as in rural areas of some developing countries. We define a specific threat model, driven by the experience of use cases covered by international projects, and prove that an intruder cannot cause damages to the safety of patients and their data by performing any of the attacks falling within this threat model. To demonstrate the feasibility and effectiveness of our protocol, we have fully implemented it

e-Health for Rural Areas in Developing Countries: Lessons from the Sebokeng Experience

We report the experience gained in an e-Health project in the Gauteng province, in South Africa. A Proof-of-Concept of the project has been already installed in 3 clinics in the Sebokeng township. The project is now going to be applied to 300 clinics in the whole province. This extension of the Proof-of-Concept can however give rise to security aws because of the inclusion of rural areas with unreliable Internet connection. We address this problem and propose a safe solution

On a Formal and User-friendly Linguistic Approach to Access Control of Electronic Health Data

The importance of the exchange of Electronic Health Records (EHRs) between hospitals has been recognized by governments and institutions. Due to the sensitivity of data exchanged, only mature standards and implementations can be chosen to operate. This exchange process is of course under the control of the patient, who decides who has the rights to access her personal healthcare data and who has not, by giving her personal privacy consent. Patients’ privacy consent is regulated by local legislations, which can vary frequently from region to region. The technology implementing such privacy aspects must be highly adaptable, often resulting in complex security scenarios that cannot be easily managed by patients and software designers. To overcome such security problems, we advocate the use of a linguistic approach that relies on languages for expressing policies with solid mathematical foundations. Our approach bases on FACPL, a policy language we have intentionally designed by taking inspiration from OASIS XACML, the de-facto standard used in all projects covering secure EHRs transmission protected by patients’ privacy consent. FACPL can express policies similar to those expressible by XACML but, differently from XACML, it has an intuitive syntax, a formal semantics and easy to use software tools supporting policy development and enforcement. In this paper, we present the potentialities of our approach and outline ongoing work

Towards Model-Driven Development of Access Control Policies for Web Applications

We introduce a UML-based notation for graphically modeling systems’ security aspects in a simple and intuitive way and a model-driven process that transforms graphical specifications of access control policies in XACML. These XACML policies are then translated in FACPL, a policy language with a formal semantics, and the resulting policies are evaluated by means of a Java-based software tool

A Standard-Driven Communication Protocol for Disconnected Clinics in Rural Areas

Abstract-The importance of the Electronic Health Record (EHR), which stores all healthcare-related data belonging to a patient, has been recognized in recent years by governments, institutions, and industry. Initiatives like Integrating the Healthcare Enterprise (IHE) have been developed for the definition of standard methodologies for secure and interoperable EHR exchanges among clinics and hospitals. Using the requisites specified by these initiatives, many large-scale projects have been set up to enable healthcare professionals to handle patients' EHRs. Applications deployed in these settings are often considered safety-critical, thus ensuring such security properties as confidentiality, authentication, and authorization is crucial for their success. In this paper, we propose a communication protocol, based on the IHE specifications, for authenticating healthcare professionals and assuring patients' safety in settings where no network connection is available, such as in rural areas of some developing countries. We define a specific threat model, driven by the experience of use cases covered by international projects, and prove that an intruder cannot cause damages to the safety of patients and their data by performing any of the attacks falling within this threat model. To demonstrate the feasibility and effectiveness of our protocol, we have fully implemented it

Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites

Human serum albumin (HSA) is a monomeric allosteric protein. Here, the effect of ibuprofen on denitrosylation kinetics (k(off)) and spectroscopic properties of HSA-heme-Fe(II)-NO is reported. The k(off) value increases from (1.4 +/- 0.2) x 10(-4) s(-1), in the absence of the drug, to (9.5 +/- 1.2) x 10(-3) s(-1), in the presence of 1.0 x 10(-2) M ibuprofen, at pH 7.0 and 10.0 degrees C. From the dependence of k(off) on the drug concentration, values of the dissociation equilibrium constant for ibuprofen binding to to HSA-heme-Fe(II)-NO (K-1 = (3.1 +/- 0.4) x 10(-7) M, K-2= (1.7 +/- 0.2) x 10(-4) M. and K-3 (2.2 +/- .2) x 10(-3) M) were determined. The K-3 value corresponds to the HSA-heme-Fe(II)-NO determined by monitoring drug-dependent absorbance spectroscopic changes (H = (2.6 +/- 0.3) x 10(-3) M). Present data indicate that ibuprofen binds to the FA3-FA4 cleft (Sudlow's site II), to the FA6 site, and possibly to the FA2 pocket, inducing the hexa-coordination of HSA-heme-Fe(II)-NO and triggering the heme-ligand dissociation kinetics. (C) 2009 Elsevier Inc. All rights reserved

Pre-lift Valve Actuation Strategy for the Performance Improvement of a DISI VVA Turbocharged Engine

Abstract Modern internal combustion engines (ICEs) are becoming more and more complex in order to achieve not only better power and torque performance, but also to respect the pollutant emissions and the fuel consumption (CO 2 ) limits. The turbocharger, advanced valve actuation systems (VVA) and the EGR circuit allow the ICE's load control together with the traditional throttle valve and spark advance. Thus, an higher number of operating parameters are available for the calibration engineer to achieve the required performance target (minimum fuel consumption at part load, maximum power and torque at full load, etc.). On the other hand, the increased degrees of freedom may frustrate the potentialities of so complex systems because of the effort needed to identify the optimal engine control strategies. The development of proper numerical models may assist and direct the experimental activity in order to reduce the related times and costs. Although VVA solutions could bring a reduction in the specific fuel consumption thanks to an important de-throttling of the intake system, unfortunately they can simultaneously lead to higher noise levels radiated by the intake mouth. In fact, in this case, the pressure waves travelling through the intake ducts are not properly damped by the throttle valve. In this paper a numerical methodology is developed to define the engine calibration and the intake valve lift profile that simultaneously minimize the BSFC and the noise at part load. The engine object of the study is a turbocharged Spark-Ignition Direct Injection (SIDI) ICE equipped by a lost motion valve actuation system for the intake valves. In this study, the commercial 1D thermo fluid-dynamic code GT-PowerTM is provided with user routines for the description of the combustion process and the handing of variable valve lift profiles. The engine model is thus integrated with a commercial optimization code (modeFRONTIERTM) to identify the optimized load control strategies to achieve the set objectives. The proposed methodology is also used for the definition of unconventional valve lift profiles. Particularly, the advantages related to the use of a small pre-lift before the main valve lift profile are estimated compared to a conventional EIVC strategy

On a Formal and User-Friendly Linguistic Approach to Access Control of Electronic Health Data

Abstract: The importance of the exchange of Electronic Health Records (EHRs) between hospitals has been recognized by governments and institutions. Due to the sensitivity of data exchanged, only mature standards and implementations can be chosen to operate. This exchange process is of course under the control of the patient, who decides who has the rights to access her personal healthcare data and who has not, by giving her personal privacy consent. Patients' privacy consent is regulated by local legislations, which can vary frequently from region to region. The technology implementing such privacy aspects must be highly adaptable, often resulting in complex security scenarios that cannot be easily managed by patients and software designers. To overcome such security problems, we advocate the use of a linguistic approach that relies on languages for expressing policies with solid mathematical foundations. Our approach bases on FACPL, a policy language we have intentionally designed by taking inspiration from OASIS XACML, the de-facto standard used in all projects covering secure EHRs transmission protected by patients' privacy consent. FACPL can express policies similar to those expressible by XACML but, differently from XACML, it has an intuitive syntax, a formal semantics and easy to use software tools supporting policy development and enforcement. In this paper, we present the potentialities of our approach and outline ongoing work