Implication incidence age groups in cancer patients who suffer from death rumination disorder and employed psychological defense styles

Background: Cancer is malignant disease with high risk of incidences which disease lead to stressful and pressure condition. This study was done to analyse age groups in cancer patients who suffer from death rumination disorder and employed psychological defense styles.Methods: The study was done using two questionnaires such as: death rumination questionnaire and defense style questionnaire-60 (DSQ-60). Study was conducted in 200 patients who after oncologist diagnosis bedded in hospital. Investigation used all data collected analysed by SPSS version 21 software, the MANOVA test was used.Results: In particular, 46-55 years old was in high risk of age group in cancer population, there was a statistical significant difference on death rumination disorder and employing psychological defense styles with regard to age. Age groups correlated with death focus factor of death rumination disorder. Age rank correlated with sublimation, self-assertion, splitting-self, help-rejecting, undoing, affiliation factors of defense styles.Conclusions: Findings of this study revealed that there is difference between age groups, death rumination disorder and psychological defense styles in cancer patients. Death rumination is response of distress and death thinking which make by cancer diseases, then defense styles in patients encounter for adaptive with pressure and stressful condition of diseases

Implication incidence age groups in cancer patients who suffer from death rumination disorder and employed psychological defense styles

Background: Cancer is malignant disease with high risk of incidences which disease lead to stressful and pressure condition. This study was done to analyse age groups in cancer patients who suffer from death rumination disorder and employed psychological defense styles.Methods: The study was done using two questionnaires such as: death rumination questionnaire and defense style questionnaire-60 (DSQ-60). Study was conducted in 200 patients who after oncologist diagnosis bedded in hospital. Investigation used all data collected analysed by SPSS version 21 software, the MANOVA test was used.Results: In particular, 46-55 years old was in high risk of age group in cancer population, there was a statistical significant difference on death rumination disorder and employing psychological defense styles with regard to age. Age groups correlated with death focus factor of death rumination disorder. Age rank correlated with sublimation, self-assertion, splitting-self, help-rejecting, undoing, affiliation factors of defense styles.Conclusions: Findings of this study revealed that there is difference between age groups, death rumination disorder and psychological defense styles in cancer patients. Death rumination is response of distress and death thinking which make by cancer diseases, then defense styles in patients encounter for adaptive with pressure and stressful condition of diseases

Research study in cancer by gender, age groups, and kinds of cancer

Background: Cancer is a malignant disease with high incidence in both genders and all age groups. The prevalence of these serious types of cancer which also vary according to age groups and kinds of cancer must be known. Studies are a must to get more attention to these diseases and occasions for prevention of widespread occurrence. Objective: This study was done to study the estimated cancer incidence by gender, age groups, and kinds of cancer in patients. Materials and Methods: 200 cases of cancer patients that were admitted in oncology wards of the hospital after diagnosis with cancer and getting surgery, chemotherapy and radiology in Iran, Zahedan city region, were studied. The study lasted from 12th April 2014 to 20th March 2015. Data collection was during 12 months by follow-up of patients. Collected data of gender, age groups, and kinds of cancer were assessed with frequency statistics test. Results: In particular, females of 35-39 and 50-54 age groups were more vulnerable, and Leukemia was the most frequent type of cancer in the affected population. Cancer research by gender and age groups shows female in 40-44 and male in 35-39 age groups were in high-risk groups. Furthermore, cancer by gender and kinds of cancer indicate that females suffer from leukemia more than males; in contrast, males are affected by lymphoma with higher rate than females. Conclusions: Findings in this study revealed different results in gender, variety of age groups, and kinds of cancer. We studied some important factors to assess high-risk groups in every region of world. This finding gives useful information to reduce high susceptibility risk by positive lifestyle choices, not smoking, eating a healthy diet, being physically active, and improving health education

Association between Genetic Variants Linked to Premature Ovarian Insufficiency and Inflammatory Markers: A Cross-Sectional Study

Background: Premature menopause (PM) is the cessation of ovarian function before age 40. PM women are more likelyto have cardiovascular diseases (CVDs), diabetes, and mental disorders. This is the first study that assessed the associationof single nucleotide polymorphisms (SNPs) with anti-heat shock protein 27 (Hsp27), High-sensitivity C-reactive protein(hs-CRP), and PM and serum pro-oxidant-antioxidant balance (PAB), as putative risk factors for CVDs. We aimed toexplore the association of oxidative stress markers with eight different SNPs shown to be related to premature menopause.Materials and Methods: In this cross-sectional research, we included 183 healthy women and 117 premature menopausalwomen. We determined baseline characteristics for all participants and measured serum hs-CRP, anti-HSP-27 antibody titer, and PAB levels using the established methods. Genotyping for eight SNPs was done usingthe tetra amplification refractory mutation system polymerase chain reaction (Tetra-ARMS PCR) and allele-specificoligonucleotide PCR (ASO-PCR) methods.Results: We found a significant difference between mean serum PAB levels and the genetic variant of rs16991615(P=0.03). ANCOVA showed a significant effect of the genotypes rs4806660 and rs10183486 on hs-CRP serum levelsin the case and control groups, respectively (P=0.04 and P=0.007). ANCOVA also showed an association betweenrs244715 genotypes and anti-hsp27 serum levels in the case group (P=0.02). There was a significant effect of thegenotypes of rs451417 on the serum hs-CRP level in the control group (P=0.03).Conclusion: There was a significant association of the genetic variants related to PM with oxidative stress and inflammatorymarkers (serum PAB, anti-hsp27 antibody, and hs-CRP). Accordingly, this seems to be an effective approach topredicting susceptible subjects for cardiovascular and mental disorders as well as various cancers

Soluble Fas might serve as a diagnostic tool for gastric adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Fas (Apo-1/CD95) and its specific ligand (FasL) are key elements in apoptosis. They have been studied in different malignancies but there are few published studies about the soluble forms of these markers (i.e. sFas/sFasL) in gastric cancer. We have compared the serum levels of sFas/sFasL in gastric adenocarcinoma patients and cases with pre-neoplastic lesions as potential markers for early diagnosis, and investigated their relation with clinicopathological characteristics.</p> <p>Methods</p> <p>Fifty-nine newly-diagnosed cases of gastric adenocarcinoma who had undergone gastrectomy, along with 62 endoscopically- and histologically-confirmed non-cancer individuals were enrolled in this study. sFas/sFasL serum levels were detected by Enzyme Linked Immunosurbent Assay.</p> <p>Results</p> <p>Mean serum sFas level was significantly higher in gastric cancer patients than in control group (305.97 ± 63.71 (pg/ml) vs. 92.98 ± 4.95 (pg/ml), P < 0.001); while the mean serum level of sFasL was lower in patients with gastric adenocarcinoma (0.138 ± 0.04 (pg/ml) vs. 0.150 ± 0.02 (pg/ml), P < 0.001). Mean serum levels of sFas/sFasL were significantly different in both intestinal/diffuse and cardiac/non-cardiac subtypes when compared to the control group (P < 0.001). There was an increase in the serum level of sFas from the first steps of pre-neoplastic lesions to gastric adenocarcinoma (P < 0.001). Patients who had no lymph node involvement (<it>N₀</it>) showed significantly higher serum levels of sFas compared to others (P = 0.044).</p> <p>Conclusions</p> <p>Production of sFas may play a critical role in the carcinogenesis of intestinal-type gastric cancer. sFas serum level may serve as a non-invasive tool for early diagnosis of gastric cancer.</p

Multiple necking patterns in elasto-plastic rings subjected to rapid radial expansion: the effect of random distributions of geometric imperfections

In this paper we have investigated, using finite element calculations performed in ABAQUS/Explicit [1], the effect of ab initio geometric imperfections in the development of multiple necking patterns in ductile rings subjected to dynamic expansion. Specifically, we have extended the work of Rodríguez-Martínez et al. [2], who studied the formation of necks in rings with sinusoidal spatial perturbations of predefined amplitude and constant wavelength, by considering specimens with random distributions of perturbations of varying amplitude and wavelength. The idea, which is based on the work of El Maï et al. [3], is to provide an idealized modeling of the surface defects and initial roughness of the rings and explore their effect on the collective behavior and spacing of the necks. The material behavior has been modeled with von Mises plasticity and constant yield stress, and the finite element simulations have been performed for expanding velocities ranging from 10 m/s to 1000 m/s, as in ref. [2]. For each speed, we have performed calculations varying the number of imperfections in the ring from 5 to 150. In order to obtain statistically significant results, for each number of imperfections, the computations have been run with five random distributions of imperfection wavelengths. For a small number of imperfections, the variability in the wavelengths distribution is large, which makes the imperfections play a major role in the necking pattern, largely controlling the spacing and growth rate of the necks. As the number of imperfections increases, the variability in the wavelengths distribution decreases, giving rise to an array of more regularly spaced necks which grow at more similar speed. A key outcome is to show that, for a large number of imperfections, the number of necks formed in the ring comes closer to the number of necks obtained in the absence of ab initio geometric imperfections.The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme. Project PURPOSE, grant agreement 758056