Ion beam induced modification and nanostructures formation in thin SiC/Pd films on c-Si substrate

Ion beam induced modification of thin metallic films is an emerging approach to grow metallic nanoparticles controllably. Modification of thin solid films is helpful in fabricating arrays of nanoscale particles for electronic and photonic devices and for the catalyzed synthesis of nanotubes and nanowires. In this work, the modification and nanostructures formation over the surface of SiC/Pd thin films of 15 and 45 nm thicknesses, grown on crystalline Silicon (c-Si) substrate by electron beam deposition, upon ion irradiation, have been investigated by means of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), Rutherford backscattering spectrometry (RBS), Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopy. The SiC/Pd bilayer films were irradiated with 100 keV Ar+ ions at fluences of 1 × 1015 and 5 × 1015 ions/cm2 at room temperature. The surface morphology from SEM analysis showed the formation of nanoparticles that were interconnected after irradiation. The RBS and EDS results confirmed the presence of Pd, C, O and Si. While the Raman spectrum of the pristine sample displayed only a sharp peak at 520 cm−1 characteristic to c-Si substrate, the spectra of the irradiated sample red-shifted to lower wavenumbers indicating the appearance of Si nanocrystals. Hence, ion beam irradiation is a promising method for the fabrication of SiC nanostructures on c-Si substrate

Digital preservation practices in academic libraries in South Africa in the wake of the digital revolution

Background: The preservation of digital resources in academic institutions in South Africa is an imperative because of the proliferation of digital resources and the realities of the digital revolution. The study focused on digital preservation practices within academic libraries in South Africa. A number of studies were undertaken in the field of preservation in South Africa and they focused on the preservation of cultural heritage, preservation of electronic government and preservation of public digital information. The major gap in the literature reinforces the need to closely examine digital preservation practices in academic libraries in South Africa. There is a need to understand the extent of preservation of digital resources in various contexts in order to guarantee access to them for future generations. This will improve our understanding of the preservation of digital resources in academic libraries in the wake of the digital revolution. Objectives: The purpose of this study was to investigate digital preservation practices in academic libraries in South Africa in order to suggest solutions for effective digital preservation. Method: The survey research method was used for data collection. Twenty-seven academic institutions in South Africa were surveyed. Data were analysed through the Statistical Package for the Social Sciences. Results: The findings revealed that academic libraries experienced difficulties in preserving and sustaining their digital resources because of the absence of established standards, policies and procedures, inadequate resources, as well as a lack of skills and training. They also had difficulties with limited funding and collaboration efforts, and the threat of technological obsolescence because of the constantly changing software and hardware, poor technology infrastructure and legal issues. Conclusion: All these challenges have created the need for best practices and solutions to facilitate the long-term preservation of digital resources in the academic libraries. Recommendations were made on the basis of the results

Proverbs 31:10-31 in a South African context : a bosadi (womanhood) perspective

One of the presuppositions of the present research is that readers and their contexts play a significant role in the interpretation of biblical texts. The key text of this thesis is Proverbs 31: 10-31 and the main readers are African women in a kyriarchal South African (Northern Sotho) context. Given their context of a multiplicity of oppressive forces ( racism, sexism, classism and African culture), how can these women read Proverbs 31: 10-31 appropriately with a view to their liberation? The researcher proposes a new woman's liberationist perspective, a Bosadi perspective, a perspective committed amongst others, to the African-ness of the African woman in South Africa. The question is: If Proverbs 31:10-31 is read from a Bosadi (Womanhood) perspective, how will the Northern Sotho women in a South African context find the text - a text emerging from a kyriarchal Hebraic culture? Will they find it to be oppressive or liberative or will it be found to be containing both elements? The present researcher, like many reformist women liberation biblical scholars (cf some feminists and womanists ), argues that though the Bible emerged from patriarchal cultures, and contains elements oppressive to women, it also has liberative elements. Through the use of socio-critical hermeneutics, reception criticism and historical-criticism, evidence supporting this came to light as the present researcher re-read Proverbs 31:10-31 from a Bosadi critical perspective. It is therefore argued that when the Bible was used by the previous proponents of apartheid to subordinate people of other races, Black Theologians re-read the Bible from a Black perspective and used it for the racial liberation of Black South Africans. Likewise, an average South African woman, particularly an African woman, is basically a victim of male interpreters who use the Bible to subordinate women. It is the task of all African women to take the responsibility upon themselves to use appropriate tools in re-reading the Bible in order to discover that the Bible does not only alienate them, it is also the liberating word; the word which makes more sense to them because of their relationship with the Word which became flesh (Jn 1:1).D. Litt. et Phil. (Biblical Studies

An African-conscious female's reading of Steve Biko

Papers presented at the Forum for Religious Dialogue Symposium of the Research Institute for Theology and Religion held at the University of South Africa, Pretoria, 23-24 August 2008.Research Institute for Theology and Religio

Is Ruth the "eset hayil" for real? An exploration of womanhood from African proverbs to the threshing floor (Ruth 3:1-13)

Peer reviewedContradictory definitions of what a worthy womanhood is, have in many contexts, including African contexts, caused divisions within religious institutions, families and communities at large. In Christian African contexts, definitions of worthy womanhood emerging from various Bible interpretations, and shaped by different African cultures, have influenced and continue to influence views concerning women and men, boyand girl-children, even as these mould our definitions of what affirming gender relationships (should) entail. In Ruth 3:11, Boaz, the wealthy Judahite man, informs Ruth, the poor foreign (Moabite) widow, that the assembly of Judahite men knows that she is the 'ēšet ḥayil, the woman of substance. Which images of womanhood are revealed when some African proverbs are read in conjunction with Boaz’s words in Ruth 3:11? Do these images indeed reveal Ruth as the woman of substance? Do they resonate with those who seek affirming definitions of womanhood in our African contexts? This article will address these questions, among others.Research Institute for Theology and Religio

Pathogen infection influences a distinct microbial community composition in sorghum RILs

AIMS: The rhizosphere microbiome substantially affects plant health, yet comparatively little is known regarding the foliar community dynamics. Here, we examine the relationship between the microbiota and their response to natural infection by pathogens. METHODS: We established an experimental system using a set of sorghum recombinant inbred lines (RILS). These RILS included four models denoted as resistant, moderately resistant, susceptible and highly susceptible. A combination of 16S rRNA and ITS gene amplicon approaches was used to assess bacteria and fungi, respectively, in foliar samples. RESULTS: We show that the foliar microbiome differs substantially in asymptomatic and symptomatic RILs subsequent to natural infection by pathogens. A significant association was found between plant health and microbial community structure. Our analyses revealed several distinct fungal and bacterial pathogens. These pathogens included Gibberella and Pantoea genera, which were associated with the highly susceptible group. In addition to these pathogens, we also found signatures for Ascochyta, a known plant pathogenic genus. Members of the bacterial genus Methylorubrum and the fungal genus Hannaella, both known to exhibit plant growthpromoting (PGP) traits, were associated with the resistant and moderately resistant groups. These data also reveal numerous highly diverse fungal and bacterial taxa in RILs that did not show symptoms. We also found taxonomic differences between the microbiota hosted by the symptomatic and asymptomatic RILs. CONCLUSIONS: Together, these data suggest that pathogen infection may result in distinct microbiota. These results suggest that highly diverse microbiome may promote the plants ability to resist the effects of pathogens potentially contributing to plant health.The National Research Foundation, the Agricultural Research Council and the University of South Africa.http://link.springer.com/journal/11104pm2022BiochemistryGeneticsMicrobiology and Plant Patholog

Dolutegravir plus two different prodrugs of tenofovir to treat HIV

BACKGROUND: Two drugs under consideration for inclusion in antiretroviral therapy (ART) regimens for human immunodeficiency virus (HIV) infection are dolutegravir (DTG) and tenofovir alafenamide fumarate (TAF). There are limited data on their use in low- and middle-income countries. METHODS: We conducted a 96-week, phase 3, investigator-led, open-label, randomized trial in South Africa, in which we compared a triple-therapy combination of emtricitabine (FTC) and DTG plus either of two tenofovir prodrugs - TAF (TAF-based group) or tenofovir disoproxil fumarate (TDF) (TDF-based group) - against the local standard-of-care regimen of TDF-FTC-efavirenz (standard-care group). Inclusion criteria included an age of 12 years or older, no receipt of ART in the previous 6 months, a creatinine clearance of more than 60 ml per minute (>80 ml per minute in patients younger than 19 years of age), and an HIV type 1 (HIV-1) RNA level of 500 copies or more per milliliter. The primary end point was the percentage of patients with a 48-week HIV-1 RNA level of less than 50 copies per milliliter (as determined with the Snapshot algorithm from the Food and Drug Administration; noninferiority margin, -10 percentage points). We report the primary (48-week) efficacy and safety data. RESULTS: A total of 1053 patients underwent randomization from February 2017 through May 2018. More than 99% of the patients were black, and 59% were female. The mean age was 32 years, and the mean CD4 count was 337 cells per cubic millimeter. At week 48, the percentage of patients with an HIV-1 RNA level of less than 50 copies per milliliter was 84% in the TAF-based group, 85% in the TDF-based group, and 79% in the standard-care group, findings that indicate that the DTG-containing regimens were noninferior to the standard-care regimen. The number of patients who discontinued the trial regimen was higher in the standard-care group than in the other two groups. In the per-protocol population, the standard-care regimen had equivalent potency to the other two regimens. The TAF-based regimen had less effect on bone density and renal function than the other regimens. Weight increase (both lean and fat mass) was greatest in the TAF-based group and among female patients (mean increase, 6.4 kg in the TAF-based group, 3.2 kg in the TDF-based group, and 1.7 kg in the standard-care group). No resistance to integrase inhibitors was identified in patients receiving the DTG-containing regimens. CONCLUSIONS: Treatment with DTG combined with either of two tenofovir prodrugs (TAF and TDF) showed noninferior efficacy to treatment with the standard-care regimen. There was significantly more weight gain with the DTG-containing regimens, especially in combination with TAF, than with the standard-care regimen. (ADVANCE ClinicalTrials.gov number, NCT03122262.)

Taking up the cudgels against gay rights? Trends and trajectories in African Christian theologies on homosexuality

Against the background of the HIV epidemic and the intense public controversy on homosexuality in African societies, this article investigates the discourses of academic African Christian theologians on homosexuality. Distinguishing some major strands in African theology, that is, inculturation, liberation, women’s and reconstruction theology, the article examines how the central concepts of culture, liberation, justice, and human rights function in these discourses. On the basis of a qualitative analysis of a large number of publications, the article shows that stances of African theologians are varying from silence and rejection to acceptance. Although many African theologians have taken up the cudgels against gay rights, some “dissident voices” break the taboo and develop more inclusive concepts of African identity and African Christianity

Final 192-week efficacy and safety results of the ADVANCE trial, comparing 3 first-line antiretroviral regimens

BACKGROUND: ADVANCE compared 3 World Health Organization-recommended first-line regimens in participants with HIV who were antiretroviral naive. METHODS: This randomized, open-label, noninferiority trial enrolled participants living with HIV with no antiretroviral exposure in the previous 6 months to 1 of the following arms: tenofovir alafenamide (TAF) / emtricitabine (FTC) + dolutegravir (DTG) (2 tablets), tenofovir disoproxil fumarate (TDF) / FTC + DTG (2 tablets), or a fixed-dose combination of TDF / FTC / efavirenz (EFV) (1 tablet). We report the final safety and efficacy data up to 192 weeks. RESULTS: Repeat consent from the original 351 participants randomized to each arm was obtained from 230 participants (66%) in the TAF/FTC + DTG arm, 209 (60%) in the TDF/FTC + DTG arm, and 183 (52%) in the TDF/FTC/EFV arm. At 192 weeks, 213 (61%) of the original 351 participants in the TAF/FTC + DTG arm, 195 (56%) in the TDF/FTC + DTG arm, and 172 (49%) in the TDF/FTC/EFV arm had confirmed RNA <50 copies/mL, with low virologic failure in all groups and no significant integrase inhibitor mutations in any arm. Mean weight gain was 8.9 kg (SD, 7.1) in the TAF/FTC + DTG arm, 5.9 kg (SD, 7.1) in the TDF/FTC + DTG arm, and 3.2 kg (SD, 8.1) in the TDF/FTC/EFV arm at 192 weeks from baseline and was greatest among women, those taking TAF, and those with lower baseline CD4 counts. The weight trajectory slowed after week 96. There were few clinical events and minor laboratory changes and differences among arms after 96 weeks. There were no significant differences in treatment-emergent hypertension or pregnancy outcomes by arm. CONCLUSIONS: High viral suppression was seen across arms, with no resistance to DTG. Weight gain continued but slowed after 96 weeks, with few clinical events or laboratory changes