Science from an Ultra-Deep, High-Resolution Millimeter-Wave Survey

Opening up a new window of millimeter-wave observations that span frequency bands in the range of 30 to 500 GHz, survey half the sky, and are both an order of magnitude deeper (about 0.5 uK-arcmin) and of higher-resolution (about 10 arcseconds) than currently funded surveys would yield an enormous gain in understanding of both fundamental physics and astrophysics. In particular, such a survey would allow for major advances in measuring the distribution of dark matter and gas on small-scales, and yield needed insight on 1.) dark matter particle properties, 2.) the evolution of gas and galaxies, 3.) new light particle species, 4.) the epoch of inflation, and 5.) the census of bodies orbiting in the outer Solar System.Comment: 5 pages + references; Submitted to the Astro2020 call for science white paper

Snowmass2021 CMB-HD White Paper

CMB-HD is a proposed millimeter-wave survey over half the sky that would be ultra-deep (0.5 uK-arcmin) and have unprecedented resolution (15 arcseconds at 150 GHz). Such a survey would answer many outstanding questions about the fundamental physics of the Universe. Major advances would be 1.) the use of gravitational lensing of the primordial microwave background to map the distribution of matter on small scales (k~10 h Mpc^(-1)), which probes dark matter particle properties. It will also allow 2.) measurements of the thermal and kinetic Sunyaev-Zel'dovich effects on small scales to map the gas density and velocity, another probe of cosmic structure. In addition, CMB-HD would allow us to cross critical thresholds: 3.) ruling out or detecting any new, light (< 0.1 eV) particles that were in thermal equilibrium with known particles in the early Universe, 4.) testing a wide class of multi-field models that could explain an epoch of inflation in the early Universe, and 5.) ruling out or detecting inflationary magnetic fields. CMB-HD would also provide world-leading constraints on 6.) axion-like particles, 7.) cosmic birefringence, 8.) the sum of the neutrino masses, and 9.) the dark energy equation of state. The CMB-HD survey would be delivered in 7.5 years of observing 20,000 square degrees of sky, using two new 30-meter-class off-axis crossed Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors

Snowmass2021 CMB-HD White Paper

CMB-HD is a proposed millimeter-wave survey over half the sky that would be ultra-deep (0.5 uK-arcmin) and have unprecedented resolution (15 arcseconds at 150 GHz). Such a survey would answer many outstanding questions about the fundamental physics of the Universe. Major advances would be 1.) the use of gravitational lensing of the primordial microwave background to map the distribution of matter on small scales (k~10 h Mpc^(-1)), which probes dark matter particle properties. It will also allow 2.) measurements of the thermal and kinetic Sunyaev-Zel'dovich effects on small scales to map the gas density and velocity, another probe of cosmic structure. In addition, CMB-HD would allow us to cross critical thresholds: 3.) ruling out or detecting any new, light (< 0.1 eV) particles that were in thermal equilibrium with known particles in the early Universe, 4.) testing a wide class of multi-field models that could explain an epoch of inflation in the early Universe, and 5.) ruling out or detecting inflationary magnetic fields. CMB-HD would also provide world-leading constraints on 6.) axion-like particles, 7.) cosmic birefringence, 8.) the sum of the neutrino masses, and 9.) the dark energy equation of state. The CMB-HD survey would be delivered in 7.5 years of observing 20,000 square degrees of sky, using two new 30-meter-class off-axis crossed Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors

Snowmass2021 CMB-HD White Paper

CMB-HD is a proposed millimeter-wave survey over half the sky that would be ultra-deep (0.5 uK-arcmin) and have unprecedented resolution (15 arcseconds at 150 GHz). Such a survey would answer many outstanding questions about the fundamental physics of the Universe. Major advances would be 1.) the use of gravitational lensing of the primordial microwave background to map the distribution of matter on small scales (k~10 h Mpc^(-1)), which probes dark matter particle properties. It will also allow 2.) measurements of the thermal and kinetic Sunyaev-Zel'dovich effects on small scales to map the gas density and velocity, another probe of cosmic structure. In addition, CMB-HD would allow us to cross critical thresholds: 3.) ruling out or detecting any new, light (< 0.1 eV) particles that were in thermal equilibrium with known particles in the early Universe, 4.) testing a wide class of multi-field models that could explain an epoch of inflation in the early Universe, and 5.) ruling out or detecting inflationary magnetic fields. CMB-HD would also provide world-leading constraints on 6.) axion-like particles, 7.) cosmic birefringence, 8.) the sum of the neutrino masses, and 9.) the dark energy equation of state. The CMB-HD survey would be delivered in 7.5 years of observing 20,000 square degrees of sky, using two new 30-meter-class off-axis crossed Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors

Science from an Ultra-Deep, High-Resolution Millimeter-Wave Survey

Opening up a new window of millimeter-wave observations that span frequency bands in the range of 30 to 500 GHz, survey half the sky, and are both an order of magnitude deeper (about 0.5 uK-arcmin) and of higher-resolution (about 10 arcseconds) than currently funded surveys would yield an enormous gain in understanding of both fundamental physics and astrophysics. In particular, such a survey would allow for major advances in measuring the distribution of dark matter and gas on small-scales, and yield needed insight on 1.) dark matter particle properties, 2.) the evolution of gas and galaxies, 3.) new light particle species, 4.) the epoch of inflation, and 5.) the census of bodies orbiting in the outer Solar System

Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial

Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI. Interpretation: In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk