A 10b 320 MS/s 40 mW Open-Loop Interpolated Pipeline ADC

Abstract An open-loop interpolated pipeline ADC is proposed. Weight controlled capacitor arrays are introduced to realize an interpolation and a pipelined operation with open-loop amplifiers. The 10-bit ADC fabricated in 90 nm CMOS demonstrates ENOB of 8.5b over 80 MHz bandwidth (BW) and a conversion rate of 320 MS/s without linearity compensation and consumes 40 mW. The FoMs are 780 fJ/c. Circuit description The input offset voltages, which reduce the linearity, are canceled and the accurate interpolated voltages can be generated if the gains of amplifiers are sufficiently similar. The first amplifiers use the differential CMOS amplifier with source degeneration resistors, as shown in Measurement results and conclusion The chip is fabricated in 90 nm CMOS technology and occupied area is 0.46 mm 2 , as shown i

Increased Serum KL-6 Levels Induced by Pulmonary Mycobacterium Avium Complex Infection in a Patient with RA-associated Lung Disease

KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection

Endoscopic Manifestations and Clinical Characteristics of Localized Gastric Light-Chain Amyloidosis

To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant

Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

There have been no comparative studies investigating the results of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients with gastric mesenchymal tumors, including leiomyomas, leiomyosarcomas, schwannomas, and gastrointestinal stromal tumors (GISTs). We retrospectively reviewed the data of 142 patients with pathologically diagnosed gastric mesenchymal tumors treated at 11 institutions. We analyzed the correlation between the maximum standardized uptake value (SUVmax) evaluated using fluorodeoxyglucose-positron emission tomography (FDG-PET) and the tumor size. The correlation between the SUVmax and mitotic index was also investigated in GISTs. The SUVmax (mean +/- standard deviation) was 0.5 +/- 0.6 in very low-risk GISTs (n = 42), 2.1 +/- 0.7 in low-risk GISTs (n = 26), 4.9 +/- 0.8 in intermediate-risk GISTs (n = 22), 12.3 +/- 0.8 in high-risk GISTs (n = 20), 1.0 +/- 1.0 in leiomyomas (n = 15), 6.9 +/- 1.2 in schwannomas (n = 10), and 3.5 in a leiomyosarcoma (n = 1). The SUVmax of GISTs with an undetermined risk classification was 4.2 +/- 1.3 (n = 8). Linear associations were observed between the SUVmax and tumor size in GISTs, leiomyomas, and schwannomas. The SUVmax of GISTs with a high mitotic index was significantly higher than that of GISTs with a low mitotic index (9.6 +/- 7.6 vs. 2.4 +/- 4.2). In conclusion, we observed positive correlations between the SUVmax and tumor size in GISTs, leiomyomas, and schwannomas. The SUVmax also positively correlated with the mitotic index and risk grade in GISTs. Schwannomas showed a higher FDG uptake than GISTs and leiomyomas

ｴﾘｰﾄ空手道選手の合宿中における栄養素等摂取状況

本研究の目的は､全日本空手道連盟ﾅｼｮﾅﾙﾁｰﾑ所属選手の合宿中の栄養素等摂取状況について検討することである｡対象は合宿に参加した選手45名である｡被検者を男子組手群20名と形群7名､女子組手群11名と形群7名の4群に分けた｡4群の PFC 比(P:たんぱく質､F:脂質､C:炭水化物に対するｴﾈﾙｷﾞｰ比率)の範囲は､たんぱく質ｴﾈﾙｷﾞｰ比が11.9±1.3～13.2±1.1%､脂質ｴﾈﾙｷﾞｰ比が28.5±4.8～29.3±3.3%､炭水化物ｴﾈﾙｷﾞｰ比が56.6±3.3～58.8±4.3%であった｡炭水化物とたんぱく質の平均摂取量は､推奨されている値と比較すると適切であった｡ﾋﾞﾀﾐﾝとﾐﾈﾗﾙの摂取量を増加させるために我々は､乳･乳製品､緑黄色野菜､淡色野菜の摂取を増加させることを勧めた｡The purpose of this study was to collect baseline data on nutrient intake of elite Japanese karate players during training camp. The subjects were 27 men and 18 women who were members of the national team in Japan. They were divided into 4 groups:20 men\u27s sparring(M-Spar Group), 7 men\u27s kata(M-Kata Group), 11 women\u27s sparring(W-Spar Group), 7 women\u27s kata(W-Kata Group). The percentage of energy from protein ranged from 11.9±1.3～13.2±1.1%, 28.5±4.8～29.3±3.3% from fat, 56.6±3.3～58.8±4.3% from carbohydrates. The mean carbohydrate and protein intakes were adequate in comparison with the respective recommended targets. To increase mineral and vitamin intakes, we recommended athletes to increase consumptions of milk and dairy products, green and other vegetables