Entity Identification Problem in Big and Open Data

Big and Open Data provide great opportunities to businesses to enhance their competitive advantages if utilized properly. However, during past few years’ research in Big and Open Data process, we have encountered big challenge in entity identification reconciliation, when trying to establish accurate relationships between entities from different data sources. In this paper, we present our innovative Intelligent Reconciliation Platform and Virtual Graphs solution that addresses this issue. With this solution, we are able to efficiently extract Big and Open Data from heterogeneous source, and integrate them into a common analysable format. Further enhanced with the Virtual Graphs technology, entity identification reconciliation is processed dynamically to produce more accurate result at system runtime. Moreover, we believe that our technology can be applied to a wide diversity of entity identification problems in several domains, e.g., e- Health, cultural heritage, and company identities in financial world.Ministerio de Ciencia e Innovación TIN2013-46928-C3-3-

Exploiting Linked Data in Financial Engineering

Part 3: Finance and Service ScienceInternational audienceIn this paper, we report on a recent initiative that exploiting Linked Data for financial data integration. Financial data present high heterogeneity. Linked Data helps to reveal the true data semantics and “hidden” connection, upon which meaningful mappings can be constructed. The work reported in this paper has been well-accepted at several public events and conferences, including the 26th XBRL conference, involving the realisation of the XBRL (eXtensible Business Reporting Language) prototype called HIKAKU, which means “comparison” in Japanese. It demonstrates our approach to exploit the power of Linked Data in enhancing flexibility for data integration in the financial domain

Entity Identity Reconciliation based Big Data Federation-A MDE approach

“Information is power” is a sentence attributed to Francis Bacon that acquired a high important in the current era of the information. However, too much information can be a negative aspect. The term of “Infoxication” refers to the difficulty a person can have understanding an issue and making decisions that can be caused by the presence of too much information. With the increasing of relevance of open data and big database, the application of mechanisms and solutions to manage information is critical. This paper introduces the problem of unique identification and data reconciliation and offers a discussion about how to solve this problem in big and open data environment. The problem of data reconciliation in multiple databases and the unique identification of entities is not a new problem, but, how effective are classical mechanisms in the new internet environment? In this paper a solution based on model-driven engineering and virtual graph is presented in order to improve the processing of information in big open repositories. The paper illustrates the idea with a real example for the right exploitation of heritage information in the south of Spain

Entity Identity Reconciliation based Big Data Federation A MDE approach

“Information is power” is a sentence attributed to Francis Bacon that acquired a high important in the current era of the information. However, too much information can be a negative aspect. The term of “Infoxication” refers to the difficulty a person can have understanding an issue and making decisions that can be caused by the presence of too much information. With the increasing of relevance of open data and big database, the application of mechanisms and solutions to manage information is critical. This paper introduces the problem of unique identification and data reconciliation and offers a discussion about how to solve this problem in big and open data environment. The problem of data reconciliation in multiple databases and the unique identification of entities is not a new problem, but, how effective are classical mechanisms in the new internet environment? In this paper a solution based on model-driven engineering and virtual graph is presented in order to improve the processing of information in big open repositories. The paper illustrates the idea with a real example for the right exploitation of heritage information in the south of Spain.Ministerio de Ciencia e Innovación TIN2013-46928-C3-3-

Patterns of C-reactive protein trends during clozapine titration and the onset of clozapine-induced inflammation: a case series of weekly and daily C-reactive protein monitoring

BackgroundInternational guidelines for clozapine titration recommend measuring C-reactive protein (CRP) weekly for 4 weeks after clozapine initiation to prevent fatal inflammatory adverse events, including myocarditis. However, limited evidence exists regarding whether weekly CRP monitoring can prevent clozapine-induced inflammation.AimsWe examined the relationship between CRP trends and the development of clozapine-induced inflammation. We also explored the usefulness and limitations of CRP monitoring during clozapine titration.MethodThis study presents 17 and 4 cases of weekly and daily CRP monitoring during clozapine initiation, respectively.ResultsAmong 17 patients with weekly CRP measurements, 7 had fever. Elevated CRP levels were detected before the onset of fever in two of the seven patients. Of the five remaining patients, the CRP levels on a previous test had been low; however, the fever developed suddenly. Of the 10 patients with no fever under weekly CRP monitoring, three had elevated CRP levels >3.0 mg/dL. Refraining from increasing the clozapine dose may have prevented fever in these patients. Among four patients with daily CRP measurements, two became febrile. In both cases, CRP levels increased almost simultaneously with the onset of fever.ConclusionWeekly and daily CRP monitoring during clozapine titration is valuable for preventing clozapine-induced inflammation, assessing its severity, and guiding clozapine dose adjustments. Weekly CRP monitoring may not adequately predict clozapine-induced inflammation in some cases. Consequently, clinicians should be aware of the sudden onset of clozapine-induced inflammation, even if CRP levels are low. Daily CRP monitoring is better for detecting clozapine-induced inflammation

High-throughput analysis of ultrasonication-forced amyloid fibrillation reveals the mechanism underlying the large fluctuation in the lag time

This research was originally published in the Journal of Biological Chemistry. Ayaka Umemoto, Hisashi Yagi, Masatomo So and Yuji Goto. High-throughput Analysis of Ultrasonication-forced Amyloid Fibrillation Reveals the Mechanism Underlying the Large Fluctuation in the Lag Time. J. Biol. Chem. 2014; 289, 27290–27299. © the American Society for Biochemistry and Molecular Biolog

Supersaturation-limited and unlimited phase transitions compete to produce the pathway complexity in amyloid fibrillation

Although amyloid fibrils and amorphous aggregates are two types of aggregates formed by denatured proteins, their relationship currently remains unclear. We used β2-microglobulin (β2m), a protein responsible for dialysis-related amyloidosis, to clarify the mechanism by which proteins form either amyloid fibrils or amorphous aggregates. When ultrasonication was used to accelerate the spontaneous fibrillation of β2m at pH 2.0, the effects observed depended on ultrasonic power; although stronger ultrasonic power effectively accelerated fibrillation, excessively strong ultrasonic power decreased the amount of fibrils formed, as monitored by thioflavin T fluorescence. An analysis of the products formed indicated that excessively strong ultrasonic power generated fibrillar aggregates that retained β-structures but without high efficiency as seeds. On the other hand, when the spontaneous fibrillation of β2m was induced at higher concentrations of NaCl at pH 2.0 with stirring, amorphous aggregates became more dominant than amyloid fibrils. These apparent complexities in fibrillation were explained comprehensively by a competitive mechanism in which supersaturation-limited reactions competed with supersaturation-unlimited reactions. We link the kinetics of protein aggregation and a conformational phase diagram, in which supersaturation played important roles.This research was originally published in the Journal of Biological Chemistry. Masayuki Adachi, Masatomo So, Kazumasa Sakura, József Kardos and Yuji Goto. Supersaturation-limited and Unlimited Phase Transitions Compete to Produce the Pathway Complexity in Amyloid Fibrillation. J. Biol. Chem. 2015; 290, 18134-18145. © the American Society for Biochemistry and Molecular Biolog