Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma

<p>Abstract</p> <p>Background</p> <p>Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma.</p> <p>Methods</p> <p>A total of 694 patients with histologically confirmed ovarian (135 patients) or uterine cancer (258 with cervical cancer, 301 with endometrial cancer) who underwent lymph node dissection were studied retrospectively. Logistic regression analyses were used to identify the risk factors associated with occurrence of lymphedema.</p> <p>Results</p> <p>Among ovarian and uterine cancer patients who underwent pelvic lymph node dissection, post-operative radiotherapy (odds ratio: 1.79; 95% confidence interval: 1.20–2.67; p = 0.006) was statistically significantly associated with occurrence of lymphedema.</p> <p>Conclusion</p> <p>There was no relationship between any surgical procedure and occurrence of lymphedema among patients undergoing pelvic lymphadenectomy. Our findings are supported by a sound biological rationale because they suggest that limb lymphedema is caused by pelvic lymph node dissection.</p

ΩΩ\Omega\Omega interaction from 2+1 flavor lattice QCD

We investigate the interaction between $\Omega$ baryons in the $^1S_0$ channel from 2+1 flavor lattice QCD simulations. On the basis of the HAL QCD method, the $\Omega\Omega$ potential is extracted from the Nambu-Bethe-Salpeter wave function calculated on the lattice by using the PACS-CS gauge configurations with the lattice spacing $a\simeq 0.09$ fm, the lattice volume $L\simeq 2.9$ fm and the quark masses corresponding to $m_\pi \simeq 700$ MeV and $m_\Omega \simeq 1970$ MeV. The $\Omega\Omega$ potential has a repulsive core at short distance and an attractive well at intermediate distance. Accordingly, the phase shift obtained from the potential shows moderate attraction at low energies. Our data indicate that the $\Omega\Omega$ system with the present quark masses may appear close to the unitary limit where the scattering length diverges.Comment: 9 pages, 4 figures, 1 tabl

Continuous release of O2−/ONOO− in plasma-exposed HEPES-buffered saline promotes TRP channel-mediated uptake of a large cation

Although the externally controllable extracellular supply of the short-lived reactive oxygen and nitrogen species, such as O2•−, •NO, and ONOO−, could potentially manipulate cellular functions, their simple administration to cells is likely to be ineffective due to their rapid deactivation. In this study, we found a method of a continuous supply of O2•−/ONOO− over a few minutes, which is triggered by irradiation of a nonequilibrium atmospheric pressure plasma to commonly used organic buffers (e.g., 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, HEPES). In addition, a continuous low-dose O2•−/ONOO− supply was shown to induce a physiologically relevant Ca2+ response and subsequently the uptake of a large cation mediated by transient receptor potential channel family member(s). Our results provide a novel approach to the continuous O2•−/ONOO− supply, requiring controllable and mass-volume treatments

The relationship between ambulatory ability before surgery and the D-dimer value after total hip arthroplasty: the evaluation of ambulatory ability by the timed "Up & Go" test.

We examined whether ambulatory ability before surgery might influence the post-operative D-dimer level after total hip arthroplasty (THA). One hundred two patients with hip osteoarthritis receiving THA were included in the current study. The patients were all female, and their ages ranged from 45 to 81 (average 65.0 +- 9.3 years). Age, operated side, body mass index (BMI), disease duration before surgery, pre-operative pain evaluated by visual analogue scale (VAS), total cholesterol value, maximal circumference of the lower leg of the operated side, and timed &#34;Up &#38; Go&#34;test (TUG) before surgery, were retrospectively investigated to examine their relationship with D-dimer levels on post-operative day 7. Patients were divided into 2 groups according to the D-dimer value: over 10 microg/ml (Group D), and under (Group N). Patients in group D (N= 52)were older, had a higher BMI, and had less ambulatory ability than patients in group N (N= 50). As age showed a relationship with the D-dimer value on the 7th day and TUG results, patients in the 2 groups were further subdivided into 50's, 60's, and 70's age brackets. In the 50's bracket, patients in group D had higher BMI than patients in group N, but time for TUG was not significantly different. In the 60's and 70's bracket, patients in group D had less ambulatory ability than patients in group N, but the time for TUG was not directly correlated with the D-dimer value. The results suggest that pre-operative low ambulatory ability in patients with osteoarthritis over 60 years might influence the postoperative D-dimer after THA, indicating the potential risk for post-operative deep venous thrombosis.</p

New Technology On High Performance And Reliability Of Mechanical Drive Steam Turbines.

LecturePg. 145-154The new design technology of the mechanical drive steam turbines used in the chemical plant industry is presented. In order to improve the performance of high speed turbines, the new high pressure ratio impulse stage has been developed. Low pressure blade design technology was also established by using the flow analysis technology. With respect to the high reliability of the turbines, the new analysis technology for steam whirl vibration characteristics, direct lubrication bearing, and erosion prevention technology have been developed

Enhancement of Dormant Pathways in the Brain following Rat Contusive Spinal Cord Injury

Spinal cord injury (SCI) induces distal effects on neural activity in the brain. To date, precise, high quality anatomical studies have not been performed. The goal of this study was to delineate neuroanatomical enhancement of dormant pathways in the brain following SCI using an appropriate serotype of an adeno-associated-virus (AAV) with a CAG promotor

Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain

Abstract Background The transcription factor Pax6 is essential for the development of the central nervous system and it exerts its multiple functions by regulating the expression of downstream target molecules. To screen for genes downstream of Pax6, we performed comprehensive transcriptome profiling analyses in the early hindbrain of Pax6 homozygous mutant and wild-type rats using microarrays. Results Comparison of quadruplicate microarray experiments using two computational methods allowed us to identify differentially expressed genes that have relatively small fold changes or low expression levels. Gene ontology analyses of the differentially expressed molecules demonstrated that Pax6 is involved in various signal transduction pathways where it regulates the expression of many receptors, signaling molecules, transporters and transcription factors. The up- or down-regulation of these genes was further confirmed by quantitative RT-PCR. In situ staining of Fabp7, Dbx1, Unc5h1 and Cyp26b1 mRNAs showed that expression of these transcripts not only overlapped with that of Pax6 in the hindbrain of wild-type and Pax6 heterozygous mutants, but also was clearly reduced in the hindbrain of the Pax6 homozygous mutant. In addition, the Pax6 homozygous mutant hindbrain showed that Cyp26b1 expression was lacked in the dorsal and ventrolateral regions of rhombomeres 5 and 6, and that the size of rhombomere 5 expanded rostrocaudally. Conclusions These results indicate that Unc5h1 and Cyp26b1 are novel candidates for target genes transactivated by Pax6. Furthermore, our results suggest the interesting possibility that Pax6 regulates anterior-posterior patterning of the hindbrain via activation of Cyp26b1, an enzyme that metabolizes retinoic acid

Definitive Identification of the Transition between Small- to Large-Scale Clustering for Lyman Break Galaxies

We report angular correlation function (ACF) of Lyman Break Galaxies (LBGs) with unprecedented statistical quality on the basis of 16,920 LBGs at z=4 detected in the 1 deg^2 sky of the Subaru/XMM-Newton Deep Field. The ACF significantly departs from a power law, and shows an excess on small scale. Particularly, the ACF of LBGs with i'<27.5 have a clear break between the small and large-scale regimes at the angular separation of ~7'' whose projected length corresponds to the virial radius of dark halos with a mass of 10^11-12 Mo, indicating multiple LBGs residing in a single dark halo. Both on small (2''<theta<3'') and large (40''<theta<400'') scales, clustering amplitudes monotonically increase with luminosity for the magnitude range of i'=24.5-27.5, and the small-scale clustering shows a stronger luminosity dependence than the large-scale clustering. The small-scale bias reaches b~10-50, and the outskirts of small-scale excess extend to a larger angular separation for brighter LBGs. The ACF and number density of LBGs can be explained by the cold dark matter model.Comment: Accepted for publication in ApJL. 5 pages, 4 figures. The text and Figures 2-4 have been revised. There is no major change which affects to the main discussion shown in the original preprint. This paper with high resolution figures is available at http://www-int.stsci.edu/~ouchi/work/astroph/sxds_z4LBG/ouchi_highres.pdf (PDF