Effect of Sensory Manipulations on Human Joint Stiffness Strategy and Its Adaptation for Human Dynamic Stability

Sensory input plays an important role to human posture control system to initiate strategy in order to counterpart any unbalance condition and thus, prevent fall. In previous study, joint stiffness was observed able to describe certain issues regarding to movement performance. But, correlation between balance ability and joint stiffness is still remains unknown. In this study, joint stiffening strategy at ankle and hip were observed under different sensory manipulations and its correlation with conventional clinical test (Functional Reach Test) for balance ability was investigated. In order to create unstable condition, two different surface perturbations (tilt up-tilt (TT) down and forward-backward (FB)) at four different frequencies (0.2, 0.4, 0.6 and 0.8 Hz) were introduced. Furthermore, four different sensory manipulation conditions (include vision and vestibular system) were applied to the subject and they were asked to maintain their position as possible. The results suggested that joint stiffness were high during difficult balance situation. Less balance people generated high average joint stiffness compared to balance people. Besides, adaptation of posture control system under repetitive external perturbation also suggested less during sensory limited condition. Overall, analysis of joint stiffening response possible to predict unbalance situation faced by human

Simulation studies on temperature profile stiffness in ITG turbulent transport of helical plasmas for flux-matching technique

In the framework of the flux-matching method, which is a useful way for the validation of the gyrokinetic turbulence simulations, it is strongly demanded to evaluate the plasma profile sensitivity of the transport coefficients obtained in the employed simulation model within the profile gradient ranges estimated from the experimental observations. The sensitivity causes the plasma profile stiffness for wide ranges of the transport fluxes. In the nonlinear gyrokinetic simulations for the ion temperature gradient (ITG) turbulence in the Large Helical Device (LHD) [Takeiri et al., Nucl. Fusion 57, 102023 (2017)], it is found that the temperature gradients around the experimental nominal observations are slightly larger than the threshold of the instability, and the ion heat diffusivities are quite sensitive to the temperature gradient. The growth rates of the instability, the generations of the zonal flows, and the sensitivities of the transport coefficients to the temperature profiles depend on the radial locations, the employed simulation models, and the field configurations. Specifically, in the optimized LHD field configuration, the sensitivities are relaxed in the outer radial region due to the enhancement of the zonal flows and the reduction of the ITG instability. In order to estimate the range of the temperature gradients possible given the experimentally obtained data of the temperature with errorbars, the statistical technique, Akaike\u27s Information Criterion [H. Akaike, in Proceedings of the 2nd International Symposium on Information Theory, edited by B. N. Petrov and F. Caski (Akadimiai Kiado, Budapest, 1973), pp. 267–281] is applied. Against the range of the temperature gradients, the flux-matching method to predict the temperature gradient in helical plasmas is demonstrated

Modeling of turbulent particle and heat transport in helical plasmas based on gyrokinetic analysis

The particle and heat transport driven by the ion temperature gradient instability in helical plasmas is investigated by the gyrokinetic analysis taking into account the kinetic electron response. High and low ion temperature plasma cases for the discharge in the Large Helical Device (LHD) are studied. Two types of transport models with a lower computational cost to reproduce the nonlinear gyrokinetic simulation results within allowable errors are presented for application in quick transport analyses. The turbulent electron and ion heat diffusivity models are given in terms of the linear growth rate and the characteristic quantity for the linear response of zonal flows, while the model of the effective particle diffusivity is not obtained for the flattened density profile observed in the LHD. The quasilinear flux model is also shown for the heat transport. The quasilinear flux models for the energy fluxes are found to reproduce the nonlinear simulation results at the accuracy similar to that of the heat diffusivity models. In addition, the quasilinear particle flux model, which is applicable to the transport analysis for LHD plasmas, is constructed. These turbulent reduced models enable coupling to the other simulation in the integrated codes for the LHD

A case of small cell gastric carcinoma with an adenocarcinoma component operated curatively.

We present a case of a primary advanced gastric tumor that was composed of 2 different pathological components: small cell carcinoma and moderately-differentiated adenocarcinoma. The patient was still alive four years after the surgery was performed, without recurrence. A large part of the tumor consisted of a diffuse sheet of small cell carcinoma, which transitioned into another small portion consisting of moderately-differentiated tubular adenocarcinoma components. Therefore, this case raised the possibility that small cell gastric carcinoma may originate from totipotential stem cells of the stomach. Although small cell carcinoma progresses aggressively, and patients with it have an extremely poor prognosis, this patient recovered uneventfully after the surgical resection, and has remained in good health, without any recurrences.</p

Turbulent transport of heat and particles in a high ion temperature discharge of the Large Helical Device

Turbulent transport in a high ion temperature discharge of the Large Helical Device (LHD) is investigated by means of electromagnetic gyrokinetic simulations, which include kinetic electrons, magnetic perturbations, and full geometrical effects. Including kinetic electrons enables us to firstly evaluate the particle and the electron heat fluxes caused by turbulence in LHD plasmas. It is found that the electron energy transport reproduces the experimental result, and that the particle flux is negative. The contribution of magnetic perturbation to the transport is small because of very low beta. The turbulence is driven by the ion temperature gradient instability, and the effect of kinetic electrons enhances the growth rate larger than that from the adiabatic electron calculation. The ion energy flux is larger than that observed in the experiment, while the flux is close to the experimental observation when the temperature gradient is reduced 20% in the simulation. This significant sensitivity of the energy flux implies that the profile in the experiment is close to the critical temperature gradient. The critical gradient for turbulent energy flux is similar to that for the linear instability, i.e., the Dimits shift is small. This is because the zonal flow in the LHD is weaker than that in tokamaks

Drug efficacy against aortic dissection

Objective: Aortic dissection is a life-threatening disease. At present, the only therapeutic strategies available are surgery and antihypertensive drugs. Moreover, the molecular mechanisms underlying the onset of aortic dissection are still unclear. We established a novel aortic dissection model in mice using pharmacologically induced endothelial dysfunction. We then used the Japanese Adverse Drug Event Report database to investigate the role of pitavastatin in preventing the onset of aortic dissection. Methods and results: To induce endothelial dysfunction, Nω-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, was administered to C57BL/6 mice. Three weeks later, angiotensin II (Ang II) and β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, were administered with osmotic mini-pumps. False lumen formation was used as the pathological determinant of aortic dissection. The incidences of aortic dissection and death from aneurysmal rupture were significantly higher in the Nω-nitro-L-arginine methyl ester, Ang II, and BAPN (LAB) group than they were in the Ang II and BAPN (AB) group. Pitavastatin was administered orally to LAB mice. It significantly lowered the incidences of dissection and rupture. It also decreased inflammation and medial degradation, both of which were exacerbated in the LAB group. The Japanese Adverse Drug Event Report database analysis indicated that there were 113 cases of aortic dissection out of 95 090 patients (0.12%) not receiving statins but only six cases out of 16 668 patients receiving statins (0.04%) (odds ratio: 0.30; P=0.0043). Conclusion: Our results suggest that endothelial dysfunction is associated with the onset of aortic dissection and pitavastatin can help prevent this condition

Granulovacuolar Degenerations Appear in Relation to Hippocampal Phosphorylated Tau Accumulation in Various Neurodegenerative Disorders

BACKGROUND: Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles. Several lines of evidence have suggested that GVDs appear within hippocampal pyramidal neurons in AD when phosphorylated tau begins to aggregate into early-stage neurofibrillary tangles. The aim of this study is to investigate the association of GVDs with phosphorylated tau pathology to determine whether GVDs and phosphorylated tau coexist among different non-AD neurodegenerative disorders. METHODS: An autopsied series of 28 patients with a variety of neurodegenerative disorders and 9 control patients were evaluated. Standard histological stains along with immunohistochemistry using protein markers for GVD and confocal microscopy were utilized. RESULTS: The number of neurons with GVDs significantly increased with the level of phosphorylated tau accumulation in the hippocampal regions in non-AD neurodegenerative disorders. At the cellular level, diffuse staining for phosphorylated tau was detected in neurons with GVDs. CONCLUSIONS: Our data suggest that GVDs appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders, while the presence of phosphorylated tau in GVD-harbouring neurons in non-AD neurodegenerative disorders was indistinguishable from age-related accumulation of phosphorylated tau. Although GVDs in non-AD neurodegenerative disorders have not been studied thoroughly, our results suggest that they are not incidental findings, but rather they appear in relation to phosphorylated tau accumulation, further highlighting the role of GVD in the process of phosphorylated tau accumulation

Effect of Sensory Manipulations on Human Joint Stiffness Strategy and Its Adaptation for Human Dynamic Stability

Sensory input plays an important role to human posture control system to initiate strategy in order to counterpart any unbalance condition and thus, prevent fall. In previous study, joint stiffness was observed able to describe certain issues regarding to movement performance. But, correlation between balance ability and joint stiffness is still remains unknown. In this study, joint stiffening strategy at ankle and hip were observed under different sensory manipulations and its correlation with conventional clinical test (Functional Reach Test) for balance ability was investigated. In order to create unstable condition, two different surface perturbations (tilt up-tilt (TT) down and forward-backward (FB)) at four different frequencies (0.2, 0.4, 0.6 and 0.8 Hz) were introduced. Furthermore, four different sensory manipulation conditions (include vision and vestibular system) were applied to the subject and they were asked to maintain their position as possible. The results suggested that joint stiffness were high during difficult balance situation. Less balance people generated high average joint stiffness compared to balance people. Besides, adaptation of posture control system under repetitive external perturbation also suggested less during sensory limited condition. Overall, analysis of joint stiffening response possible to predict unbalance situation faced by human

Effect of Sensory Manipulations on Human Joint Stiffness Strategy and Its Adaptation for Human Dynamic Stability

Sensory input plays an important role to human posture control system to initiate strategy in order to counterpart any unbalance condition and thus, prevent fall. In previous study, joint stiffness was observed able to describe certain issues regarding to movement performance. But, correlation between balance ability and joint stiffness is still remains unknown. In this study, joint stiffening strategy at ankle and hip were observed under different sensory manipulations and its correlation with conventional clinical test (Functional Reach Test) for balance ability was investigated. In order to create unstable condition, two different surface perturbations (tilt up-tilt (TT) down and forward-backward (FB)) at four different frequencies (0.2, 0.4, 0.6 and 0.8 Hz) were introduced. Furthermore, four different sensory manipulation conditions (include vision and vestibular system) were applied to the subject and they were asked to maintain their position as possible. The results suggested that joint stiffness were high during difficult balance situation. Less balance people generated high average joint stiffness compared to balance people. Besides, adaptation of posture control system under repetitive external perturbation also suggested less during sensory limited condition. Overall, analysis of joint stiffening response possible to predict unbalance situation faced by human