119 research outputs found
Real-time face swapping as a tool for understanding infant self-recognition
International audienceTo study the preference of infants for contingency of movements and familiarity of faces during self-recognition task, we built, as an accurate and instantaneous imitator, a real-time face- swapper for videos. We present a non-constraint face-swapper based on 3D visual tracking that achieves real-time performance through parallel computing. Our imitator system is par- ticularly suited for experiments involving children with Autistic Spectrum Disorder who are often strongly disturbed by the constraints of other methods
Pressure Dependence of Superconducting Transition Temperature on Perovskite-Type Fe-Based Superconductors and NMR Study of Sr2VFeAsO3
We report the pressure dependences of the superconducting transition
temperature (T_c) in several perovskite-type Fe-based superconductors through
the resistivity measurements up to ~4 GPa. In Ca_4(Mg,Ti)_3Fe_2As_2O_y with the
highest T_c of 47 K in the present study, the T_c keeps almost constant up to
~1 GPa, and starts to decrease above it. From the comparison among several
systems, we obtained a tendency that low T_c with the longer a-axis length at
ambient pressure increases under pressure, but high T_c with the shorter a-axis
length at ambient pressure hardly increases. We also report the ^75As-NMR
results on Sr_2VFeAsO_3. NMR spectrum suggests that the magnetic ordering
occurs at low temperatures accompanied by some inhomogeneity. In the
superconducting state, we confirmed the anomaly by the occurrence of
superconductivity in the nuclear spin lattice relaxation rate 1/T_1, but the
spin fluctuations unrelated with the superconductivity are dominant. It is
conjectured that the localized V-3d moments are magnetically ordered and their
electrons do not contribute largely to the Fermi surface and the
superconductivity in Sr_2VFeAsO_3.Comment: 7 pages, 9 figure
Incidence of gastrointestinal perforation associated with bevacizumab in combination with neoadjuvant chemotherapy as first-line treatment of advanced ovarian, fallopian tube, or peritoneal cancer: analysis of a Japanese healthcare claims database
[Objective] To assess the incidence of bevacizumab-associated gastrointestinal (GI) perforation during first-line treatment of patients with ovarian, fallopian tube, or peritoneal cancer receiving neoadjuvant chemotherapy (NAC) in Japanese real-world clinical practice. [Methods] A retrospective study was conducted using a healthcare claims database owned by Medical Data Vision Co., Ltd. (study period, 2008–2020). Patients who initiated first-line treatment of ovarian, fallopian tube, or peritoneal cancer were identified and divided into NAC and primary debulking surgery (PDS) groups. The incidence of bevacizumab-associated GI perforation was compared within the NAC group and between the groups. [Results] Paclitaxel + carboplatin (TC) was most commonly used as first-line treatment (39.5% and 59.6% in the NAC and PDS groups, respectively). TC + bevacizumab was used in 9.3% and 11.6% of patients in the NAC and PDS groups, respectively. In the NAC group receiving TC, the proportion of patients with risk factors for GI perforation was lower among patients with versus without concomitant bevacizumab. The incidence of GI perforation in the NAC group was 0.38% (1/266 patients) in patients receiving TC + bevacizumab and 0.18% (2/1, 131 patients) in patients receiving TC without bevacizumab (risk ratio=2.13; 95% confidence interval [CI]=0.19 to 23.36; risk difference=0.20; 95% CI=−0.58 to 0.97). None of the 319 patients in the PDS group receiving TC + bevacizumab had GI perforation. [Conclusion] No notable increase was observed in GI perforation associated with NAC containing bevacizumab. We conclude that bevacizumab is prescribed with sufficient care in Japan to avoid GI perforation
Contrasting Pressure Effects in Sr2VFeAsO3 and Sr2ScFePO3
We report the resistivity measurements under pressure of two Fe-based
superconductors with a thick perovskite oxide layer, Sr2VFeAsO3 and Sr2ScFePO3.
The superconducting transition temperature Tc of Sr2VFeAsO3 markedly increases
with increasing pressure. Its onset value, which was Tc{onset}=36.4 K at
ambient pressure, increases to Tc{onset}=46.0 K at ~4 GPa, ensuring the
potential of the "21113" system as a high-Tc material. However, the
superconductivity of Sr2ScFePO3 is strongly suppressed under pressure. The
Tc{onset} of ~16 K decreases to ~5 K at ~4 GPa, and the zero-resistance state
is almost lost. We discuss the factor that induces this contrasting pressure
effect.Comment: 5 pages, 4 figures, to be published in J. Phys. Soc. Jpn. No.12
(2009
抗PD-1抗体への化学療法の併用はmyeloid-derived suppressor cellsを減少させることにより中皮腫の増殖を抑制する
Background: The combination of anti-PD-1/PD-L1 antibody with chemotherapy has been approved for the first-line therapy of lung cancer. However, the effects against malignant mesothelioma (MPM) and the immunological mechanisms by which chemotherapy enhances the effect of targeting PD-1/PD-L1 in MPM are poorly understood.
Materials and Methods: We utilized syngeneic mouse models of MPM and lung cancer and assessed the therapeutic effects of anti-PD-1 antibody and its combination with cisplatin (CDDP) and pemetrexed (PEM). An immunological analysis of tumor-infiltrating cells was performed with immunohistochemistry.
Results: We observed significant therapeutic effects of anti-PD-1 antibody against MPM. Although the effect was associated with CD8+ and CD4+ T cells in tumors, the number of Foxp3+ cells was not reduced but rather increased. Consequently, combination with CDDP/PEM significantly enhanced the antitumor effects of anti-PD-1 antibody by decreasing numbers of intratumoral myeloid-derived suppressor cells (MDSCs) and vessels probably through suppression of VEGF expression by CDDP+PEM.
Conclusions: The combination of anti-PD-1 antibody with CDDP+PEM may be a promising therapy for MPM via inhibiting the accumulation of MDSCs and vessels in tumors
Pressure effects on FeSe family superconductors
We investigated the pressure effects on the FeSe superconductor and the
related compounds. Pressure dependence of superconducting transition
temperature (Tc) for FeSe0.8S0.2 exhibits a dome-shaped behavior below 0.76
GPa. On the other hand, the Tc of FeSe0.25Te0.75 linearly increases up to 0.99
GPa. Here we discuss the relation between the physical pressure effects and the
chemical pressure effects on the FeSe system.Comment: 8 pages, 5 figures, proceedings of the 2009 M2S conferenc
Development of the Virtual Earth\u27s Magnetosphere System (VEMS)
We have constructed a new research environment for geo-space science based on 3-D visualization tool and network database; Virtual Earth\u27s Magnetosphere System (VEMS). With an interactive research environment researchers can visually understand structures of the Earth\u27s magnetosphere using VEMS. On the VEMS, computer simulation results and observation data are simultaneously visualized, having a potential to data assimilation for geo-space studies in the future. Since the VEMS deals with time-dependent data, it also helps researchers to study dynamics of the Earth\u27s magnetosphere. We found that immersive data analyses are possible using the VEMS on a virtual reality system
Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice
金沢大学附属病院がん高度先進治療センターBone metastases occur in more than one-third of patients with advanced lung cancer and are difficult to treat. We showed previously the therapeutic effect of a third-generation bisphosphonate, minodronate, and antiparathyroid hormone-related protein (PTHrP) neutralizing antibody on bone metastases induced by the human small cell lung cancer cell line, SBC-5, in natural killer cell-depleted severe combined immunodeficient mice. The purpose of our current study was to examine the effect of the combination of PTHrP antibody and zoledronic acid, which has been approved to treat bone metastases, against bone metastases produced by SBC-5 cells expressing PTHrP. Treatment with PTHrP antibody and/or zoledronic acid did not affect the proliferation of SBC-5 cells in vitro. Repeated treatments with either PTHrP antibody or zoledronic acid inhibited the formation of osteolytic bone metastases of SBC-5 cells but had no effect on metastases to visceral organs. Importantly, combined treatment with PTHrP antibody and zoledronic acid further inhibited the formation of bone metastases. Histologic assays showed that, compared with either PTHrP antibody or zoledronic acid alone, their combination decreased the number of tumor-associated osteoclasts and increased the number of apoptotic tumor cells. These findings suggest that this novel dual-targeting therapy may be useful for controlling bone metastases in a subpopulation of small cell lung cancer patients. Copyright © 2009 American Association for Cancer Research.全文公開20100
- …