Holographic Renormalization Group

The holographic renormalization group (RG) is reviewed in a self-contained manner. The holographic RG is based on the idea that the radial coordinate of a space-time with asymptotically AdS geometry can be identified with the RG flow parameter of the boundary field theory. After briefly discussing basic aspects of the AdS/CFT correspondence, we explain how the notion of the holographic RG comes out in the AdS/CFT correspondence. We formulate the holographic RG based on the Hamilton-Jacobi equations for bulk systems of gravity and scalar fields, as was introduced by de Boer, Verlinde and Verlinde. We then show that the equations can be solved with a derivative expansion by carefully extracting local counterterms from the generating functional of the boundary field theory. The calculational methods to obtain the Weyl anomaly and scaling dimensions are presented and applied to the RG flow from the N=4 SYM to an N=1 superconformal fixed point discovered by Leigh and Strassler. We further discuss a relation between the holographic RG and the noncritical string theory, and show that the structure of the holographic RG should persist beyond the supergravity approximation as a consequence of the renormalizability of the nonlinear sigma model action of noncritical strings. As a check, we investigate the holographic RG structure of higher-derivative gravity systems, and show that such systems can also be analyzed based on the Hamilton-Jacobi equations, and that the behaviour of bulk fields are determined solely by their boundary values. We also point out that higher-derivative gravity systems give rise to new multicritical points in the parameter space of the boundary field theories.Comment: 95 pages, 6 figures. Typos are corrected. References and a discussion about continuum limit are adde

A Note on the Weyl Anomaly in the Holographic Renormalization Group

We give a prescription for calculating the holographic Weyl anomaly in arbitrary dimension within the framework based on the Hamilton-Jacobi equation proposed by de Boer, Verlinde and Verlinde. A few sample calculations are made and shown to reproduce the results that are obtained to this time with a different method. We further discuss continuum limits, and argue that the holographic renormalization group may describe the renormalized trajectory in the parameter space. We also clarify the relationship of the present formalism to the analysis carried out by Henningson and Skenderis.Comment: LaTeX, 24 pages, 2 figures, typos correcte

Higher-Derivative Gravity and the AdS/CFT Correspondence

We investigate the AdS/CFT correspondence for higher-derivative gravity systems, and develop a formalism in which the generating functional of the boundary field theory is given as a functional that depends only on the boundary values of bulk fields. We also derive a Hamilton-Jacobi-like equation that uniquely determines the generating functional, and give an algorithm calculating the Weyl anomaly. Using the expected duality between a higher-derivative gravity system and N=2 superconformal field theory in four dimensions, we demonstrate that the resulting Weyl anomaly is consistent with the field theoretic one.Comment: 34 pages, LaTeX2e, minor change

Comment on Ambiguities in the Holographic Weyl Anomaly

We consider possible ambiguities in the holographic Weyl anomaly that are caused by local terms in the flow equation. We point out that such ambiguities actually do not give physically meaningful contributions to the Weyl anomaly.Comment: LaTeX file, 7 pag

Differentiation of carcinosarcoma from endometrial carcinoma on magnetic resonance imaging using deep learning

Purpose: To verify whether deep learning can be used to differentiate between carcinosarcomas (CSs) and endometrial carcinomas (ECs) using several magnetic resonance imaging (MRI) sequences. Material and methods: This retrospective study included 52 patients with CS and 279 patients with EC. A deep-learning model that uses convolutional neural networks (CNN) was trained with 572 T2-weighted images (T2WI) from 42 patients, 488 apparent diffusion coefficient of water maps from 33 patients, and 539 fat-saturated contrast-enhanced T1-weighted images from 40 patients with CS, as well as 1612 images from 223 patients with EC for each sequence. These were tested with 9-10 images of 9-10 patients with CS and 56 images of 56 patients with EC for each sequence, respectively. Three experienced radiologists independently interpreted these test images. The sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUC) for each sequence were compared between the CNN models and the radiologists. Results: The CNN model of each sequence had sensitivity 0.89-0.93, specificity 0.44-0.70, accuracy 0.83-0.89, and AUC 0.80-0.94. It also showed an equivalent or better diagnostic performance than the 3 readers (sensitivity 0.43-0.91, specificity 0.30-0.78, accuracy 0.45-0.88, and AUC 0.49-0.92). The CNN model displayed the highest diagnostic performance on T2WI (sensitivity 0.93, specificity 0.70, accuracy 0.89, and AUC 0.94). Conclusions: Deep learning provided diagnostic performance comparable to or better than experienced radiologists when distinguishing between CS and EC on MRI

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.

The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus. Owing to the avascular nature of the IVD and lack of understanding the mechanisms that maintain the IVD, current therapies do not lead to tissue regeneration. Here we show that homeobox protein Mohawk (Mkx) is a key transcription factor that regulates AF development, maintenance and regeneration. Mkx is mainly expressed in the outer AF (OAF) of humans and mice. In Mkx(-/-) mice, the OAF displays a deficiency of multiple tendon/ligament-related genes, a smaller OAF collagen fibril diameter and a more rapid progression of IVD degeneration compared with the wild type. Mesenchymal stem cells overexpressing Mkx promote functional AF regeneration in a mouse AF defect model, with abundant collagen fibril formation. Our results indicate a therapeutic strategy for AF regeneration

Periductal Induction of High Endothelial Venule-Like Vessels in Type 1 Autoimmune Pancreatitis

信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第946号）・丸山 雅史This is a non-final version of an article published in final form in PANCREAS. 42(1):53-59 (2013).Objectives: Type 1 autoimmune pancreatitis (AIP) is histologically characterized by dense lymphoplasmacytic infiltration and marked storiform fibrosis, manifestations associated with pancreatic ducts. Such periductal lymphocyte recruitment is thought to be elicited by dysregulation of mechanisms governing physiological lymphocyte homing. The present study was undertaken to determine whether vascular addressins including peripheral lymph node addressin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) play a role in type 1 AIP histogenesis. Methods: Tissue sections of type 1 AIP and tumor-associated non-AIP chronic pancreatitis, as well as normal pancreas, were subjected to immunohistochemical analysis using vascular addressin-related antibodies. Results: The number of periductal mouse endothelial cell antigen 79-positive high endothelial venule (HEV)-like vessels was increased in type 1 AIP relative to that seen in non-AIP chronic pancreatitis, whereas the number of MAdCAM-1-positive HEV-like vessels did not differ between the 2 conditions. Mouse endothelial cell antigen 79 antigens are expressed on duct-forming epithelial cells not only in pancreas but also in salivary glands, which often harbor extrapancreatic lesions in type 1 AIP. Conclusions: Type 1 AIP can be characterized by periductal induction of MECA-79-positive HEV-like vessels. MECA-79-positive 6-sulfo sialyl Lewis X-related carbohydrate antigens expressed on duct-forming epithelial cells could be associated with type 1 AIP pathogenesis.ArticlePANCREAS. 42(1):53-59 (2013)journal articl

Prevalence and safety of robotic surgery for gastrointestinal malignant tumors in Japan

[Aim] The National Health Insurance system has reimbursed robotic gastrointestinal surgery since April 2018 in Japan. Additionally, strict facility and surgeon standards were established by the government and the academic society. This study aimed to evaluate the prevalence and safety of robotic surgery using a Japanese nationwide web-based database. [Methods] Patients who underwent the following robotic surgeries for malignant tumors in 2018 were included: esophagectomy (RE), total gastrectomy (RTG), distal gastrectomy (RDG), proximal gastrectomy (RPG), low anterior resection (RLAR), and rectal resections other than RLAR (RRR). The number of cases and surgical mortality rates each month were calculated to evaluate the prevalence and safety of robotic procedures. [Results] A total of 3281 patients underwent robotic gastrointestinal surgery. The monthly number of robotic surgeries nearly doubled in April 2018 when they were initially reimbursed by the National Health Insurance system. Operative mortality rates were 0.9%, 0.4%, 0.2%, and 2.8% for RE (n = 330), RTG (n = 239), RDG (n = 1167), and RPG (n = 109), respectively. No mortality was observed in RLAR (n = 1062) or RRR (n = 374). [Conclusion] Robotic surgery for gastrointestinal malignant tumors was safely introduced into daily clinical practice along with rigorous surgeon and facility standards in Japan

The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging

Spontaneously hypertensive rats (SHR)as a model for aging were used in this experiment and fed a regular (50 IU/Kg diet) or high vitamin E(500IU/Kg diet) diet for 6weeks. At 12weeks old, they were killed and assayed. Although proliferation of thymic lymphocytes was significantly decreased in SHR fed the regular diet compared to Wistar Kyoto rats (WKY) fed the same diet, high vitamin E diet enhanced proliferation of thymic lymphocytes in SHR to almost the levels in WKY fed the regular diet. In addition, the expressions of both CD4 and CD8 antigens on CD4+CD8+ T cells, immature T cells existing in thymic cortex, were also decreased in SHR, and significantly improved by high vitamin E diet. These results suggest that high vitamin E diet enhances thymic lymphocyte proliferation through increased T-cell differentiation in thymus. Then, the effect of vitamin E on T-cell differentiation in thymus was investigated by using male Fisher rats. Rats were divided into three groups;vitamin E-free, regular and high vitamin E groups and fed a diet containing various levels of vitamin E(0, 50 and 500IU/Kg diet) for 7weeks. Although the percentages of CD4+CD8- and CD4-CD8+ T cells in thymocytes were significantly greater in the high vitamin E group, the percentage of CD4+CD8- T cells inversely decreased in the vitamin E-free group compared to the regular group. We have tried to investigate the mechanism of the increased T-cell differentiation in thymus of rats fed the high vitamin E diet through cytokine production, and thymic epithelial cell (TEC) and macrophage functions. We have found that vitamin E enhances T-cell differentiation through the increase of not macrophage but TEC function in thymus, which is associated with the increased binding capacity of TEC to immature T cells via increased expression of adhesion molecule, ICAM-1. These results suggest that vitamin E is a potent nutrient for promoting health in the aged via the improvement of cellular immunity decreased with aging

Consideration of impact factors on data acquisition for ocean radar with VHF band

An ocean radar with a VHF band is a useful tool for surveying coastal currents in a wide area. We have conducted a field observation of currents in Ariake Bay, the large inner sea located in the western part of Japan. Although the number of valid data acquired (hereafter, data acquisition) varies temporally and spatially, the mechanism of such variation is not yet well understood. Our aim in this study is to investigate the impact factor affecting data acquisition through field observations of current, salinity and wind in Ariake Bay. As a result, the data acquisition and the maximum measurement distance of the radar decreased owing to the decreases in salinity and wind speed. After receiving much rainfall, the data acquisition decreased rapidly in accordance with the decrease in surface salinity influenced by run-off from adjacent rivers and a flood control dike. Also, when wind speed became less than 2 m/s, the intensity of the signals received was not sufficient for the detection of current velocity. In conclusion, salinity and wind speed are important factors for steady-current observation using ocean radars.2008 International Conference on Radar (Radar 2008) : Adelaide, 2008.09.2-2008.09.