Removal of retaining washers of the waffle-spring type

Special tool removes quick-locking fasteners incorporating waffle-spring retaining washers without damage

The last ten years of research at Tarquinia

The Centro di Ricerca Coordinata ‘ProgettoTarquinia’ of the Università degli Studi di Milano is a LERU (League of European Research Universities) exemplary interdisciplinary research project that involves groups from the Università Statale di Milano (Archaeology, Information and Communication Technologies, Geoarchaeology, Palaeoanthropology), the Politecnico di Milano (Architecture and Topography) and bridges the gap between soft and hard sciences. This project stems from the ‘Progetto Tarquinia’ conceived by Maria Bonghi Jovino in 1982. During the last ten years, our integrated system of tools and services, supported by ICTs (ArchMatrix), through which multidisciplinary domain experts can examine all the typologies of data of a given culture, has made it possible to concentrate on the links between data-sources focusing on the recurrence of association rates within different aspects of material evidence and phenomena. The fields of application of our methodology in the domain of archaeology and epigraphy are multifaceted as regards the inside and outside connections of the Tarquinian heritage, whose necropolis with the famous painted tombs is a UNESCO World Heritage Site. Research includes areas of the Civita plateau: the ‘monumental complex’, the Ara della Regina sanctuary, fortifications, and archaeological sites previously explored. In the past ten years, research in the necropolis (roughly 6,000 tombs, of which 400 are painted) and in the surrounding territory has also been implemented and has produced the complete corpus of the painted tombs of Tarquinia. Our holistic approach encompasses archaeological analysis of small (mobile finds), medium (archaeological contexts) and large scale (territory and landscape) architectural analysis and applications for integrated solutions for the cultural heritage, including the first bilingual Virtual Museum dedicated to an Etruscan city

Curcumin as scaffold for drug discovery against neurodegenerative diseases

Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continuously growing. Curcumin has been proposed for the treatment of several of these pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to the ability of this molecule to reduce inflammation and aggregation of involved proteins. Nevertheless, the poor metabolic stability and bioavailability of curcumin reduce the possibilities of its practical use. For these reasons, many curcumin derivatives were synthetized in order to overcome some limitations. In this review will be highlighted recent results on modification of curcumin scaffold in the search of new effective therapeutic agents against NDs, with particular emphasis on AD

Towards realistic laparoscopic image generation using image-domain translation

Background and ObjectivesOver the last decade, Deep Learning (DL) has revolutionized data analysis in many areas, including medical imaging. However, there is a bottleneck in the advancement of DL in the surgery field, which can be seen in a shortage of large-scale data, which in turn may be attributed to the lack of a structured and standardized methodology for storing and analyzing surgical images in clinical centres. Furthermore, accurate annotations manually added are expensive and time consuming. A great help can come from the synthesis of artificial images; in this context, in the latest years, the use of Generative Adversarial Neural Networks (GANs) achieved promising results in obtaining photo-realistic images. MethodsIn this study, a method for Minimally Invasive Surgery (MIS) image synthesis is proposed. To this aim, the generative adversarial network pix2pix is trained to generate paired annotated MIS images by transforming rough segmentation of surgical instruments and tissues into realistic images. An additional regularization term was added to the original optimization problem, in order to enhance realism of surgical tools with respect to the background. Results Quantitative and qualitative (i.e., human-based) evaluations of generated images have been carried out in order to assess the effectiveness of the method. ConclusionsExperimental results show that the proposed method is actually able to translate MIS segmentations to realistic MIS images, which can in turn be used to augment existing data sets and help at overcoming the lack of useful images; this allows physicians and algorithms to take advantage from new annotated instances for their training

Preliminary engineering assessment of alternative magnetic divertor configurations for EU-DEMO

One of the main challenges in the roadmap to the realization of fusion energy is to develop a heat and power exhaust system able to withstand the large loads expected in the divertor of a fusion power plant. The challenge of reducing the heat load on the divertor targets is addressed, within the mission 2 \u2018Heat-exhaust systems\u2019, through the investigation of divertor configurations alternative to the standard Single Null (SN), such as the Snowflake (SF), Double Null (DN), X and Super-X (SX) divertors. This paper focuses on a preliminary engineering assessment of the alternative configurations proposed for the EU DEMO reactor. Starting from the description of the optimized plasma shape developed for each configuration, the 3D geometrical description of the Magnet System and of the main Mechanical Structures (Vacuum Vessel and in-vessel components) is presented. Based on the 3D geometry, the compatibility of the location and dimensions of ports with Remote Maintenance needs is discussed and possible design optimizations are proposed both for the Magnets system and the mechanical structures design. Finally, the various configurations are compared with regard to the engineering and feasibility aspects

Ammonium formate-Pd/C as a new reducing system for 1,2,4-oxadiazoles. Synthesis of guanidine derivatives and reductive rearrangement to quinazolin-4-ones with potential anti-diabetic activity

1,2,4-Oxadiazole is a heterocycle with wide reactivity and many useful applications. The reactive O-N bond is usually reduced using molecular hydrogen to obtain amidine derivatives. NH4 CO2 H-Pd/C is here demonstrated as a new system for the O-N reduction, allowing us to obtain differently substituted acylamidine, acylguanidine and diacylguanidine derivatives. The proposed system is also effective for the achievement of a reductive rearrangement of 5-(2′-aminophenyl)-1,2,4-oxadiazoles into 1-alkylquinazolin-4(1H)-ones. The alkaloid glycosine was also obtained with this method. The obtained compounds were preliminarily tested for their biological activity in terms of their cytotoxicity, induced oxidative stress, α-glucosidase and DPP4 inhibition, showing potential application as anti-diabetics