The NHANES III database: Design and a retrospective study to identify associations between vitamin D and hypertension

The results from government surveys are often available wholly or in part to the general public. However the format of this information is not always optimal for distribution or analysis, the National Health and Nutrition Examination Survey III, NHANES III, is one such example. This survey is released as data sets containing a Statistical Analysis Software (SAS) program, a column delimited data file, and documentation. This limits access to the data by requiring a license to read in and query the data. By taking the data in its available format and parsing it into a MySQL database the wealth of information contained in the survey has become more widely accessible while maintaining its completeness and without any loss in ability to query the data. The programs used to create the database consist of tools available at no cost. Recent studies have provided evidence that vitamin D may play a part in cardiovascular health. This evidence, along with the information included in the NHANES IIII, a wide range of survey and examination data, including cardiovascular health and blood serum vitamin D levels, was used to perform a retrospective study searching for a correlation between vitamin D and hypertension across age groups in white males, black males, white females and black females. The analysis found statistically significant evidence mainly in younger individuals, and especially white females that those diagnosed with hypertension have lower serum levels of vitamin D than their normotensive counterparts

Nuclear loads and nuclear shielding performance of EU DEMO divertor: A comparative neutronics evaluation of two interim design options

In a demonstrational fusion power plant (DEMO), divertor is supposed to protect vacuum vessel and superconducting magnets against neutron flux in the bottom region of the vessel. The vessel is subject to a strict design limit in irradiation damage dose and the magnets in nuclear heating power, respectively. Thus, the DEMO divertor must have the capability to protect sufficiently the vessel and the magnets against neutron flux being substantially stronger than in ITER.In this paper, a first systematic neutronics study for the European DEMO divertor is reported. Results of the extensive assessment of key nuclear loading features (nuclear heating, irradiation damage & helium production) are presented for two optional concepts, namely, dome and shielding liner including minor geometrical variants. The shielding performance of the two competing design options is discussed together with the case of a bare cassette (no shielding), particularly in terms of damage dose compared with the design limits specified for the European DEMO.It was found that both the dome and shielding liner were able to significantly reduce the nuclear loads in the cassette body and the vessel. The maximum damage dose at the end of the lifetime remained subcritical for the cassette body for both cases whereas it exceeded the limit for the vessel under the dome, but only locally on the surface underneath the pumping duct. But, the damage could be reduced below the limit for the vessel by increasing the size of the dome or by deploying the shielding liner. The most critical feature was the excessive damage occurring in the own body of the shielding components where the maximum damage dose in the steel heat sink of the dome and the shielding liner far exceeded the design limit at the end of the lifetime

Systems engineering approach for pre-conceptual design of DEMO divertor cassette

Abstract This paper presents the pre-conceptual design activities conducted for the European DEMO divertor, focusing on cassette design and Plasma Facing Components (PFC) integration. Following the systems engineering principles, a systematic design method, the Iterative and Participative Axiomatic Design Process (IPADeP), has been adopted. Basing on Axiomatic Design, IPADeP supports the early conceptual design of complex systems. The work moved from the geometrical and interface constraints imposed by the 2015 DEMO configuration model. Then, since different materials will be used for cassette and PFCs, the divertor geometry has been developed taking into account the cooling parameters of the cassette Eurofer steel and the integration of PFCs cooling system. Accordingly, the design process led to a double wall cassette structure with internal reinforcing ribs to withstand cassette coolant pressure and three different kinds of piping schemes for PFCs with dual circuits. These three solutions differs in the feeding pipes layouts and target manifold protection and they have been proposed and evaluated considering heat flux issues, shielding problems, interface requirements with blanket and vacuum vessel and remote maintenance needs. A cassette parametric shell model has been used to perform first structural analyses of the cassette body against coolant pressure. Taking advantages of the parametric surface modelling and its linkage with Finite Element (FE) code, the cassette ribs layout and thickness has been evaluated and optimized, considering at the same time the structural strength needed to withstand the coolant parameters and the maximum stiffness required for cassette preloading and locking needs

Estimation of electrode location in a rat motor cortex by laminar analysis of electrophysiology and intracortical electrical stimulation

While the development of microelectrode arrays has enabled access to disparate regions of a cortex for neurorehabilitation, neuroprosthetic and basic neuroscience research, accurate interpretation of the signals and manipulation of the cortical neurons depend upon the anatomical placement of the electrode arrays in a layered cortex. Toward this end, this report compares two in vivo methods for identifying the placement of electrodes in a linear array spaced 100 µm apart based on in situ laminar analysis of (1) ketamine–xylazine-induced field potential oscillations in a rat motor cortex and (2) an intracortical electrical stimulation-induced movement threshold. The first method is based on finding the polarity reversal in laminar oscillations which is reported to appear at the transition between layers IV and V in laminar 'high voltage spindles' of the rat cortical column. Analysis of histological images in our dataset indicates that polarity reversal is detected 150.1 ± 104.2 µm below the start of layer V. The second method compares the intracortical microstimulation currents that elicit a physical movement for anodic versus cathodic stimulation. It is based on the hypothesis that neural elements perpendicular to the electrode surface are preferentially excited by anodic stimulation while cathodic stimulation excites those with a direction component parallel to its surface. With this method, we expect to see a change in the stimulation currents that elicits a movement at the beginning of layer V when comparing anodic versus cathodic stimulation as the upper cortical layers contain neuronal structures that are primarily parallel to the cortical surface and lower layers contain structures that are primarily perpendicular. Using this method, there was a 78.7 ± 68 µm offset in the estimate of the depth of the start of layer V. The polarity reversal method estimates the beginning of layer V within ±90 µm with 95% confidence and the intracortical stimulation method estimates it within ±69.3 µm. We propose that these methods can be used to estimate the in situ location of laminar electrodes implanted in the rat motor cortex.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90825/1/1741-2552_8_4_046018.pd

EU-DEMO divertor: Cassette design and PFCs integration at pre-conceptual stage

The pre-conceptual design of the DEMO divertor cassette with a novelty, alternative path of the main cooling pipes inside cassette body is presented in this paper, focusing on cassette design and Plasma Facing Components (PFC) integration. The divertor cassette design is reviewed, considering recent updates in the DEMO configuration model as presented by the Programme Management Unit (PMU) in 2018. The new configuration requires the cooling pipes to be integrated inside the cassette body. The components affected by these changes and the impact on the divertor design are analyzed. The study focuses on a new integration system between cassette and cooling pipes. The paper describes the integration on the new cassette geometry and the divertor sub-systems. The design activities related to this system are discussed in detail in terms of CAD modeling and considerations with respect to manufacturing such as welding technologies and non-destructive testing

Policy Driven Management for Distributed Systems

Separating management policy from the automated managers which interpret the policy facilitates the dynamic change of behavior of a distributed management system. This permits it to adapt to evolutionary changes in the system being managed and to new application requirements. Changing the behavior of automated managers can be achieved by changing the policy without having to reimplement them—this permits the reuse of the managers in different environments. It is also useful to have a clear specification of the policy applying to human managers in an enterprise. This paper describes the work on policy which has come out of two related ESPRIT funded projects, SysMan and IDSM. Two classes of policy are elaborated—authorization policies define what a manager is permitted to do and obligation policies define what a manager must do. Policies are specified as objects which define a relationship between subjects (managers) and targets (managed objects). Domains are used to group the objects to which a policy applies. Policy objects also have attributes specifying the action to be performed and constraints limiting the applicability of the policy. We show how a number of example policies can be modeled using these objects and briefly mention issues relating to policy hierarchy and conflicts between overlapping policies. © 1994, Plenum Publishing Corporation. All rights reserved.Accepted versio

Insulated fixation system of plasma facing components to the divertor cassette in Eurofusion-DEMO

The design activities of an insulated Plasma Facing Components-Cassette Body (PFCs-CB) support has been carried out under the pre-conceptual design phase for Eurofusion-DEMO Work Package DIV-1 \u201cDivertor Cassette Design and Integration\u201d - Eurofusion Power Plant Physics & Technology (PPPT) program. The Eurofusion-DEMO divertor is a key in-vessel component with PFCs which directly interact with the plasma scrape-off layer. The PFCs have to cope with high heat loads, neutron irradiation and electromagnetic loads. The mechanical integrity of the PFCs and water cooling pipes can be jeopardized by high heat loads and by electromagnetic loads generated in a disruption event. In European-DEMO the possibility to estimate the heat load by measuring the relative thermocurrents is under investigation. In order to allow thermocurrents measurements, a divertor design option provides that PFCs are electrically insulated from CB. In this work authors aim to analyze the opportunity that the PFC-CB fixing system incorporates an electrical insulation system, thus acquiring also an important diagnostic role in the measurement of the thermocurrents and in the management of the current flows. The possible use of ceramic material (e.g. alumina) as the insulating layer between the support components is investigated

Thermo-hydraulic modeling of the ITER radial neutron camera

The ITER Radial Neutron Camera (RNC) is a diagnostic system designed as a multichannel detection system to measure the uncollided neutron flux from the plasma, generated in the tokamak vacuum vessel, providing information on neutron emissivity profile. The RNC consists of array of cylindrical collimators located in two diagnostic structures: the ex-port system and the in-port system. The in-port system, contains the diamond detectors which need a temperature protection. Feasibility study of the efficiency of the cooling system for the In-port Detector Modules of the RNC during baking process was the main goal of thermo-hydraulic numerical modeling. The paper presents the concept of the cooling system layout and the original way of integration of numerical thermo-hydraulic analyses of the in-port detector cassette. Due to the large extent of the detector cassette it is impossible to include all relevant thermal and hydraulic effects in one global model with sufficient level of details. Thus the modelling strategy is based on the concept of three stage modelling from details to global model. The presented paper includes results of numerical calculations made with ANSYS Fluent software in order to provide the final answer, including calculation of heat loads in the detector cassette from adjacent walls during baking and normal operation conditions

Deep learning-based overall survival prediction model in patients with rare cancer: a case study for primary central nervous system lymphoma

Purpose Primary central nervous system lymphoma (PCNSL) is a rare, aggressive form of extranodal non-Hodgkin lymphoma. To predict the overall survival (OS) in advance is of utmost importance as it has the potential to aid clinical decision-making. Though radiomics-based machine learning (ML) has demonstrated the promising performance in PCNSL, it demands large amounts of manual feature extraction efforts from magnetic resonance images beforehand. deep learning (DL) overcomes this limitation.Methods In this paper, we tailored the 3D ResNet to predict the OS of patients with PCNSL. To overcome the limitation of data sparsity, we introduced data augmentation and transfer learning, and we evaluated the results using r stratified k-fold cross-validation. To explain the results of our model, gradient-weighted class activation mapping was applied.Results We obtained the best performance (the standard error) on post-contrast T1-weighted (T1Gd)-area under curve = 0.81(0.03), accuracy = 0.87(0.07), precision = 0.88(0.07), recall = 0.88(0.07) and F1-score = 0.87(0.07), while compared with ML-based models on clinical data and radiomics data, respectively, further confirming the stability of our model. Also, we observed that PCNSL is a whole-brain disease and in the cases where the OS is less than 1 year, it is more difficult to distinguish the tumor boundary from the normal part of the brain, which is consistent with the clinical outcome.Conclusions All these findings indicate that T1Gd can improve prognosis predictions of patients with PCNSL. To the best of our knowledge, this is the first time to use DL to explain model patterns in OS classification of patients with PCNSL. Future work would involve collecting more data of patients with PCNSL, or additional retrospective studies on different patient populations with rare diseases, to further promote the clinical role of our model