Clinical outcomes and response to treatment of patients receiving topical treatments for pyoderma gangrenosum: a prospective cohort study

Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. Objective: to estimate the effectiveness of topical therapies in the treatment of PG. Methods: prospective cohort study of UK secondary care patients with a clinical diagnosis of PG suitable for topical treatment (recruited July 2009 to June 2012). Participants received topical therapy following normal clinical practice (mainly Class I-III topical corticosteroids, tacrolimus 0.03% or 0.1%). Primary outcome: speed of healing at 6 weeks. Secondary outcomes: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality-of-life; treatment failure and recurrence. Results: Sixty-six patients (22 to 85 years) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28/66 (43.8%) of ulcers healed by 6 months. Median time-to-healing was 145 days (95% CI: 96 days, ∞). Initial ulcer size was a significant predictor of time-to-healing (hazard ratio 0.94 (0.88;80 1.00); p = 0.043). Four patients (15%) had a recurrence. Limitations: No randomised comparator Conclusion: Topical therapy is potentially an effective first-line treatment for PG that avoids possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone

The ATLAS Data Acquisition and High-Level Trigger: Concept, Design and Status

The Trigger and Data Acquisition system (TDAQ) of the ATLAS experiment at the CERN Large Hadron Collider is based on a multi-level selection process and a hierarchical acquisition tree. The system, consisting of a combination of custom electronics and commercial products from the computing and telecommunication industry, is required to provide an online selection power of 105 and a total throughput in the range of Terabit/sec. This paper introduces the basic system requirements and concepts, describes the architecture of the system, discusses the basic measurements supporting the validity of the design and reports on the actual status of construction and installation

The ATLAS trigger - high-level trigger commissioning and operation during early data taking

The ATLAS experiment is one of the two general-purpose experiments due to start operation soon at the Large Hadron Collider (LHC). The LHC will collide protons at a centre of mass energy of 14~TeV, with a bunch-crossing rate of 40~MHz. The ATLAS three-level trigger will reduce this input rate to match the foreseen offline storage capability of 100-200~Hz. This paper gives an overview of the ATLAS High Level Trigger focusing on the system design and its innovative features. We then present the ATLAS trigger strategy for the initial phase of LHC exploitation. Finally, we report on the valuable experience acquired through in-situ commissioning of the system where simulated events were used to exercise the trigger chain. In particular we show critical quantities such as event processing times, measured in a large-scale HLT farm using a complex trigger menu

The ATLAS Trigger/DAQ Authorlist, version 1.0

This is a reference document giving the ATLAS Trigger/DAQ author list, version 1.0 of 20 Nov 2008

The ATLAS Trigger/DAQ Authorlist, version 2.0

This is the ATLAS Trigger/DAQ Authorlist, version 2.0, 31 July 200

The ATLAS Trigger/DAQ Authorlist, version 3.0

This is the ATLAS Trigger/DAQ Authorlist, version 3.0, 11 September 200

The ATLAS Trigger/DAQ Authorlist, version 3.1

This is the ATLAS Trigger/DAQ Authorlist, version 3.1, 17 September 200