Effect of double layers on magnetosphere-ionosphere coupling

The Earth's auroral zone contains dynamic processes occurring on scales from the length of an auroral zone field line which characterizes Alfven wave propagation to the scale of microscopic processes which occur over a few Debye lengths. These processes interact in a time-dependent fashion since the current carried by the Alfven waves can excite microscopic turbulence which can in turn provide dissipation of the Alfven wave energy. This review will first describe the dynamic aspects of auroral current structures with emphasis on consequences for models of microscopic turbulence. A number of models of microscopic turbulence will be introduced into a large-scale model of Alfven wave propagation to determine the effect of various models on the overall structure of auroral currents. In particular, the effects of a double layer electric field which scales with the plasma temperature and Debye length is compared with the effect of anomalous resistivity due to electrostatic ion cyclotron turbulence in which the electric field scales with the magnetic field strength. It is found that the double layer model is less diffusive than in the resistive model leading to the possibility of narrow, intense current structures

Modeling radiation belt radial diffusion in ULF wave fields: 2. Estimating rates of radial diffusion using combined MHD and particle codes

[1] Quantifying radial transport of radiation belt electrons in ULF wave fields is essential for understanding the variability of the trapped relativistic electrons. To estimate the radial diffusion coefficients (DLL), we follow MeV electrons in realistic magnetospheric configurations and wave fields calculated from a global MHD code. We create idealized pressure-driven MHD simulations for controlled solar wind velocities (hereafter referred to as pressure-driven Vx simulations) with ULF waves that are comparable to GOES data under similar conditions, by driving the MHD code with synthetic pressure profiles that mimic the pressure variations of a particular solar wind velocity. The ULF wave amplitude, in both magnetic and electric fields, increases at larger radial distance and during intervals with higher solar wind velocity and pressure fluctuations. To calculate DLL as a function of solar wind velocity (Vx = 400 and 600 km/s), we follow 90 degree pitch angle electrons in magnetic and electric fields of the pressure-driven Vx simulations. DLL is higher at larger radial distance and for the case with higher solar wind velocity and pressure variations. Our simulated DLL values are relatively small compared to previous studies which used larger wave fields in their estimations. For comparison, we scale our DLL values to match the wave amplitudes of the previous studies with those of the idealized MHD simulations. After the scaling, our DLL values for Vx = 600 km/s are comparable to theDLL values derived from Polar measurements during nonstorm intervals. This demonstrates the use of MHD models to quantify the effect of pressure-driven ULF waves on radiation belt electrons and thus to differentiate the radial diffusive process from other mechanisms

The excitation of the far ultraviolet electroglow emissions on Uranus, Saturn, and Jupiter

We propose that the diffuse FUV emissions of H and H_2 in excess of photoelectron excitation observed from the sunlit atmospheres of Uranus, Saturn, and Jupiter are produced by electric field acceleration of photoelectrons and ions locally in the upper atmospheres. This in situ acceleration is required to satisfy the many observational constraints on the altitude distribution, exciting particle energy, and total input energy requirements of the electroglow mechanism. We further suggest that a primary mechanism leading to this acceleration is an ionospheric dynamo, which is created in the same manner as the Earth's dynamo. The calculated altitude of charge separation by the neutral wind drag on ions across magnetic field lines is consistent with the observed peaks in electroglow emissions from the Voyager ultraviolet spectrometer limb scan data on both Saturn (near the homopause) and Uranus (just above the homopause). This dynamo action therefore appears to initiate the acceleration process, which must have the form of field-aligned potentials to accelerate the magnetized electrons. We propose that these field-aligned potentials are due to anomalous resistivity, which results from sufficiently high field-aligned currents in the ionosphere to generate plasma instabilities and therefore runaway electrons and ions above some critical lower initial energy. There are multiple candidate processes for inducing these currents, including polarization in the equivalent F regions and inner magnetospheric convection, and each of these processes should exhibit latitudinal structure. The acceleration of low-energy electrons in an H_2 atmosphere preferentially results in FUV radiation and further ionization, whereas electron acceleration in a nitrogen/oxygen atmosphere such as the Earth' is dominated by elastic scattering and thus results in electric currents. Individual electron and proton collisions with H_2 molecules will result in excitation, ionization, and heating, so that considerable enhancement of the ionospheric density and heating of the upper atmosphere will accompany the FUV emission

Central muscle relaxant effects of diazepam

Motor depressant effects of diazepam were studied in the intact, decerebrate and high spinal cat. Diazepam (0[middle dot]125-16 mg/kg i.v.) produced a depression of both the patellar and linguomandibular reflexes in the intact cat. In the high spinal (C1) cat only the linguomandibular reflex was depressed. Facilitation and inhibition of the patellar reflex elicited in both intact and high spinal (C1) cats were reduced by diazepam. No depression was observed in the in vivo neuromuscular preparation of the tibialis anticus muscle. Small doses of diazepam (0[middle dot]125 mg/kg i.v.) abolished the rigidity of the mid-collicular decerebrate cat.Mean arterial blood pressure was initially depressed in all animals (0[middle dot]125-2 mg/kg) with an intact medullary vasomotor outflow. Larger doses (4-16 mg/kg) tended to return the blood pressure toward control levels.The present study presents evidence for both a brain stem reticular and a spinal cord site of action of diazepam on motor systems. Possible mechanisms of action of diazepam on motor systems are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32707/1/0000074.pd

Genetic and environmental risk for major depression in African-American and European-American women

It is unknown whether there are racial differences in the heritability of major depressive disorder (MDD) because most psychiatric genetic studies have been conducted in samples comprised largely of white non-Hispanics. To examine potential differences between African-American (AA) and European-American (EA) young adult women in (1) DSM-IV MDD prevalence, symptomatology and risk factors and (2) genetic and/or environmental liability to MDD, we analyzed data from a large, population representative sample of twins ascertained from birth records (n= 550 AA and n=3226 EA female twins) aged 18–28 years at the time of MDD assessment by semi-structured psychiatric interview. AA women were more likely to have MDD risk factors; however, there were no significant differences in lifetime MDD prevalence between AA and EA women after adjusting for covariates (Odds Ratio = 0.88, 95% confidence interval: 0.67–1.15 ). Most MDD risk factors identified among AAs were also associated with MDD at similar magnitudes among EAs. Although the MDD heritability point estimate was higher among AA than EA women in a model with paths estimated separately by race (56%, 95% CI: 29%–78% vs. 41%, 95% CI: 29%–52%), the best-fitting model was one in which additive genetic and nonshared environmental paths for AA and EA women were constrained to be equal (A = 43%, 33%–53% and E = 57%, 47%–67%). Despite a marked elevation in the prevalence of environmental risk exposures related to MDD among AA women, there were no significant differences in lifetime prevalence or heritability of MDD between AA and EA young women

Investigation of EMIC wave scattering as the cause for the BARREL 17 January 2013 relativistic electron precipitation event: A quantitative comparison of simulation with observations

Abstract Electromagnetic ion cyclotron (EMIC) waves were observed at multiple observatory locations for several hours on 17 January 2013. During the wave activity period, a duskside relativistic electron precipitation (REP) event was observed by one of the Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) balloons and was magnetically mapped close to Geostationary Operational Environmental Satellite (GOES) 13. We simulate the relativistic electron pitch angle diffusion caused by gyroresonant interactions with EMIC waves using wave and particle data measured by multiple instruments on board GOES 13 and the Van Allen Probes. We show that the count rate, the energy distribution, and the time variation of the simulated precipitation all agree very well with the balloon observations, suggesting that EMIC wave scattering was likely the cause for the precipitation event. The event reported here is the first balloon REP event with closely conjugate EMIC wave observations, and our study employs the most detailed quantitative analysis on the link of EMIC waves with observed REP to date. Key PointsQuantitative analysis of the first balloon REP with closely conjugate EMIC wavesOur simulation suggests EMIC waves to be a viable cause for the REP eventThe adopted model is proved to be applicable to simulating the REP event

Proceedings of the Working Group Session on Fertility Preservation for Individuals with Gender and Sex Diversity

Children and adolescents with gender and sex diversity include (1) gender-nonconforming and transgender individuals for whom gender identity or expression are incongruent with birth-assigned sex (heretofore, transgender) and (2) individuals who have differences in sex development (DSD). Although these are largely disparate groups, there is overlap in the medical expertise necessary to care for individuals with both gender and sex diversity. In addition, both groups face potential infertility or sterility as a result of desired medical and surgical therapies. The Ann and Robert H. Lurie Children's Hospital of Chicago (Lurie Children's) gender and sex development program (GSDP) provides specialized multidisciplinary care for both transgender and DSD patients. In response to patient concerns that recommended medical treatments have the potential to affect fertility, the Lurie Children's GSDP team partnered with experts from the Oncofertility Consortium at Northwestern University to expand fertility preservation options to gender and sex diverse youth. This article summarizes the results of a meeting of experts across this field at the annual Oncofertility Consortium conference with thoughts on next steps toward a unified protocol for this patient group.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140296/1/trgh.2016.0008.pd

Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk

Previously, a candidate gene linkage approach on brother pairs affected with prostate cancer identified a locus of prostate cancer susceptibility at D3S1234 within the fragile histidine triad gene (FHIT), a tumor suppressor that induces apoptosis. Subsequent association tests on 16 SNPs spanning approximately 381 kb surrounding D3S1234 in Americans of European descent revealed significant evidence of association for a single SNP within intron 5 of FHIT. In the current study, resequencing and genotyping within a 28.5 kb region surrounding this SNP further delineated the association with prostate cancer risk to a 15 kb region. Multiple SNPs in sequences under evolutionary constraint within intron 5 of FHIT defined several related haplotypes with an increased risk of prostate cancer in European-Americans. Strong associations were detected for a risk haplotype defined by SNPs 138543, 142413, and 152494 in all cases (Pearson's χ2 = 12.34, df 1, P = 0.00045) and for the homozygous risk haplotype defined by SNPs 144716, 142413, and 148444 in cases that shared 2 alleles identical by descent with their affected brothers (Pearson's χ2 = 11.50, df 1, P = 0.00070). In addition to highly conserved sequences encompassing SNPs 148444 and 152413, population studies revealed strong signatures of natural selection for a 1 kb window covering the SNP 144716 in two human populations, the European American (π = 0.0072, Tajima's D= 3.31, 14 SNPs) and the Japanese (π = 0.0049, Fay & Wu's H = 8.05, 14 SNPs), as well as in chimpanzees (Fay & Wu's H = 8.62, 12 SNPs). These results strongly support the involvement of the FHIT intronic region in an increased risk of prostate cancer. © 2008 Ding et al