Substance Use, Gender Differences, and Peer Influence Among College Students

Abstract College students all around the country have encounters with peers, in which they are pressured to consume alcohol or other substances. This research project investigates the extent to which gender and social anxiety influence an individual\u27s likelihood to conform to peer pressure in the context of substance use. Conformity to peer pressure and its relationship to substance use is a critical area of study due to its implications for public health, prevention strategies, and gender-specific interventions. We will be assessing the potential of social anxiety and peer pressure influencing binge drinking on college campuses. We expect that (1) peer pressure will act on social anxiety to lower inhibitions, such that higher social anxiety will be more easily influenced by peer pressure, (2) biological females with high social anxiety will be more likely to conform to peer pressure than biological males, (3) there will be gender differences in substance use related to peer pressure. By identifying potential vulnerabilities and protective factors unique to each gender, health professionals, educators, and policymakers can better address the complex relationship between gender, peer pressure, and substance abuse. Participants were Murray State University students, 18 years or older who had access to Murray State’s SONA application. Participation is voluntary and everyone must provide consent before moving forward with the survey. The study consists of four scales related to peer pressure and substance use. Work is in progress and is currently in the data collection phase. Keywords: Social Anxiety, Peer Pressure, Substance Use, Binge Drinking

Analysis of Financial Accounting Procedures and Applications

This thesis is a compilation of accounting problems in an exploration of core accounting principles. Each case is a unique illustration of one of these financial accounting concepts and is an application of the principles and procedures associated with it. Within each case there is an executive summary describing the situation outlined in the case, the most important procedures used to solve the problem, and the ultimate outcome of the case. Following the executive summary is an appendix in which many specific questions were addressed. Additionally, within the appendices are included many figures, including journal entries, calculations, comparisons, and financial statements that were used to enhance the understanding of the subject and to draw a conclusion about the company or companies being examined

Cascading Behavior in Large Blog Graphs

How do blogs cite and influence each other? How do such links evolve? Does the popularity of old blog posts drop exponentially with time? These are some of the questions that we address in this work. Our goal is to build a model that generates realistic cascades, so that it can help us with link prediction and outlier detection. Blogs (weblogs) have become an important medium of information because of their timely publication, ease of use, and wide availability. In fact, they often make headlines, by discussing and discovering evidence about political events and facts. Often blogs link to one another, creating a publicly available record of how information and influence spreads through an underlying social network. Aggregating links from several blog posts creates a directed graph which we analyze to discover the patterns of information propagation in blogspace, and thereby understand the underlying social network. Not only are blogs interesting on their own merit, but our analysis also sheds light on how rumors, viruses, and ideas propagate over social and computer networks. Here we report some surprising findings of the blog linking and information propagation structure, after we analyzed one of the largest available datasets, with 45,000 blogs and ~ 2.2 million blog-postings. Our analysis also sheds light on how rumors, viruses, and ideas propagate over social and computer networks. We also present a simple model that mimics the spread of information on the blogosphere, and produces information cascades very similar to those found in real life

Kennedy Space Center - "America's Gateway to Space"

KSC fits into the overall NASA vision and mission by moving forward so that what we do and learn will benefit all here on Earth. In January of last year, KSC revised its Mission and Vision statements to articulate our identity as we align with this new direction the Agency is heading. Currently KSC is endeavoring to form partnerships with industry, , Government, and academia, utilizing institutional assets and technical capabilities to support current and future m!issions. With a goal of safe, low-cost, and readily available access to space, KSC seeks to leverage emerging industries to initiate development of a new space launch system, oversee the development of a multipurpose crew vehicle, and assist with the efficient and timely evolution of commercial crew transportation capabilities. At the same time, KSC is pursuing modernizing the Center's infrastructure and creating a multi-user launch complex with increased onsite processing and integration capabilities

Development of tools for embryonic ECG for heart dysfunction in zebrafish

In the past decade, the zebrafish, Danio rerio, has risen to much greater prominence as a vertebrate model system for drug discovery and toxicity testing. Zebrafish larvae represent an in vivo vertebrate model, with high throughput potential and proven efficacy as a model of human disease and drug responses. Specifically, zebrafish have been used for cardiotoxicity studies and cardiac arrhythmia modelling. This project aims to develop and optimise tools for electrocardiographic recording in zebrafish larvae for use in cardiotoxicity screening and human arrhythmia modelling. Steps were taken towards a high throughput ECG system for zebrafish larvae through establishing viability of non-contact capillary electrode recording and development of microfabricated electrode arrays capable of replacing glass capillary electrodes. In depth analysis of atrium and ventricle signals using wavelet analysis was performed and the frequency profiles for these chambers examined. The utility of the larval ECG recording system for characterisation of a cardiac mutant (cacna1c sa6050) was demonstrated through a set of drug treatments and demonstration of drug discovery through ECG analysis of chemical rescue of the mutant phenotype. Overall, the results presented highlight the zebrafish as an effective, robust and reliable model for cardiac arrhythmia and assessing drug responses in vivo

Les perspectives de l’ITT : positionner les think tanks pour qu’ils puissent influencer les débats politiques

English version available in IDRC Digital LibraryBill and Melinda Gates FoundationUK Department for International Development (DFID)William and Flora Hewlett FoundationNorwegian Agency for Development Cooperation (NORAD

Muscle Glycogen Depletion Following 75-km of Cycling Is Not Linked to Increased Muscle IL-6, IL-8, and MCP-1 mRNA Expression and Protein Content

The cytokine response to heavy exertion varies widely for unknown reasons, and this study evaluated the relative importance of glycogen depletion, muscle damage, and stress hormone changes on blood and muscle cytokine measures. Cyclists (N=20) participated in a 75-km cycling time trial (168±26.0 min), with blood and vastus lateralis muscle samples collected before and after. Muscle glycogen decreased 77.2±17.4%, muscle IL-6, IL-8, and MCP-1 mRNA increased 18.5±2.8-, 45.3±7.8-, and 8.25±1.75-fold, and muscle IL-6, IL-8, and MCP-1 protein increased 70.5±14.1%, 347±68.1%, and 148±21.3%, respectively (all, P<0.001). Serum myoglobin and cortisol increased 32.1±3.3 to 242±48.3 mg/mL, and 295±27.6 to 784±63.5 nmol/L, respectively (both P<0.001). Plasma IL-6, IL-8, and MCP-1 increased 0.42±0.07 to 18.5±3.8, 4.07±0.37 to 17.0±1.8, and 96.5±3.7 to 240±21.6 pg/mL, respectively (all P<0.001). Increases in muscle IL-6, IL-8, and MCP-1 mRNA were unrelated to any of the outcome measures. Muscle glycogen depletion was related to change in plasma IL-6 (r=0.462, P=0.040), with change in myoglobin related to plasma IL-8 (r=0.582, P=0.007) and plasma MCP-1 (r=0.457, P=0.043), and muscle MCP-1 protein (r=0.588, P=0.017); cortisol was related to plasma IL-8 (r=0.613, P=0.004), muscle IL-8 protein (r=0.681, P=0.004), and plasma MCP-1 (r=0.442, P=0.050). In summary, this study showed that muscle IL-6, IL-8, and MCP-1 mRNA expression after 75-km cycling was unrelated to glycogen depletion and muscle damage, with change in muscle glycogen related to plasma IL-6, and changes in serum myoglobin and cortisol related to the chemotactic cytokines IL-8 and MCP-1

Structural Mimicry in Class A G Protein-coupled Receptor Rotamer Toggle Switches

In this study, we tested the hypothesis that a CB1 TMH3-4-5-6 aromatic microdomain, which includes F3.25(190), F3.36(201), W5.43(280), and W6.48(357), is centrally involved in CB1 receptor activation, with the F3.36(201)/W6.48(357) interaction key to the maintenance of the CB1-inactive state. We have shown previously that when F3.36(201), W5.43(280), and W6.48(357) are individually mutated to alanine, a significant reduction in ligand binding affinity is observed in the presence of WIN 55,212-2 and SR141716A but not CP55,940 and anandamide. In the work presented here, we report a detailed functional analysis of the F3.36(201)A, F3.25(190)A, W5.43(280)A, and W6.48(357)A mutant receptors in stable cell lines created in HEK cells for agonist-stimulated guanosine 5′-3-O-(thio)triphosphate (GTPγS) binding and GIRK1/4 channel current effects in Xenopus oocytes where the mutant proteins were expressed transiently. The F3.36(201)A mutation showed statistically significant increases in ligand-independent stimulation of GTPγS binding versus wild type CB1, although basal levels for the W6.48(357)A mutant were not statistically different from wild type CB1. F3.36(201)A demonstrated a limited activation profile in the presence of multiple agonists. In contrast, enhanced agonist activation was produced by W6.48(357)A. These results suggest that a F3.36(201)/W6.48(357)-specific contact is an important constraint for the CB1-inactive state that may need to break during activation. Modeling studies suggest that the F3.36(201)/W6.48(357) contact can exist in the inactive state of CB1 and be broken in the activated state via a χ1 rotamer switch (F3.36(201) trans, W6.48(357) g+) → (F3.36(201) g+, W6.48(357) trans). The F3.36(201)/W6.48(357) interaction therefore may represent a “toggle switch” for activation of CB1