Letter from Mary E. B. Norton to John Muir, 1883 Mar 22.

[in margin: Lecture invitation Chatagua - Pacific Grove Miss Norton]01100[1]San Jose, March 22. 1883John Muir,Martinez CalaDear Sir,I have the honor of informing you that the Executive Committee of the Pacific Branch of the C.L.S.C. tender you an invitation to address the Summer Assembly which opens on the evening of July 4th and continues nine days, at Pacific Grove, Monterey. If you knew how many friends and admirers you would meet there, I am sure you would not say nay.[Page 2][in margin: [3] Mrs Muir and the little one. My brother sends kind regards and hopes you will not disappoint us. With kindest remembrances to Mrs Muir, I am Very Truly Yours, Mary E.B. Norton. Sec. of the Pacific Branch of C.L.S.C.][2]We hope to have a very large meeting, and a very good time, but it will not be perfect unless our, [poet-prophet?] will come and bring with him the inspirations of mountain, and glacier, and forest. We will send you R.R. passes, and give you the best hospitality that Pacific Grove can offer, if you will let us introduce John Muir, to his friends from all parts of the Pacific Coast. Of course we hope for a lecture, but the friends of science and Literature want to see the man. Come and brin

Gestational dating by metabolic profile at birth: a California cohort study.

BackgroundAccurate gestational dating is a critical component of obstetric and newborn care. In the absence of early ultrasound, many clinicians rely on less accurate measures, such as last menstrual period or symphysis-fundal height during pregnancy, or Dubowitz scoring or the Ballard (or New Ballard) method at birth. These measures often underestimate or overestimate gestational age and can lead to misclassification of babies as born preterm, which has both short- and long-term clinical care and public health implications.ObjectiveWe sought to evaluate whether metabolic markers in newborns measured as part of routine screening for treatable inborn errors of metabolism can be used to develop a population-level metabolic gestational dating algorithm that is robust despite intrauterine growth restriction and can be used when fetal ultrasound dating is not available. We focused specifically on the ability of these markers to differentiate preterm births (PTBs) (<37 weeks) from term births and to assign a specific gestational age in the PTB group.Study designWe evaluated a cohort of 729,503 singleton newborns with a California birth in 2005 through 2011 who had routine newborn metabolic screening and fetal ultrasound dating at 11-20 weeks' gestation. Using training and testing subsets (divided in a ratio of 3:1) we evaluated the association among PTB, target newborn characteristics, acylcarnitines, amino acids, thyroid-stimulating hormone, 17-hydroxyprogesterone, and galactose-1-phosphate-uridyl-transferase. We used multivariate backward stepwise regression to test for associations and linear discriminate analyses to create a linear function for PTB and to assign a specific week of gestation. We used sensitivity, specificity, and positive predictive value to evaluate the performance of linear functions.ResultsAlong with birthweight and infant age at test, we included 35 of the 51 metabolic markers measured in the final multivariate model comparing PTBs and term births. Using a linear discriminate analyses-derived linear function, we were able to sort PTBs and term births accurately with sensitivities and specificities of ≥95% in both the training and testing subsets. Assignment of a specific week of gestation in those identified as PTBs resulted in the correct assignment of week ±2 weeks in 89.8% of all newborns in the training and 91.7% of those in the testing subset. When PTB rates were modeled using the metabolic dating algorithm compared to fetal ultrasound, PTB rates were 7.15% vs 6.11% in the training subset and 7.31% vs 6.25% in the testing subset.ConclusionWhen considered in combination with birthweight and hours of age at test, metabolic profile evaluated within 8 days of birth appears to be a useful measure of PTB and, among those born preterm, of specific week of gestation ±2 weeks. Dating by metabolic profile may be useful in instances where there is no fetal ultrasound due to lack of availability or late entry into care

Can You Credit This? A Credit-Bearing Information Literacy Course for Graduate Health Science Students

Objective: University of Florida HSCL librarians have long offered information-related instruction through guest lectures in the programs they serve and stand-alone workshops; however, librarians had not taught any credit-bearing courses focused on information literacy prior to 2016. To more fully integrate information-related skills into curricula, librarians developed a one-credit course for graduate students, initially targeting those in basic science programs but expecting that its modular format would allow easy adaptation for other health science programs. After two successful semesters teaching this course, librarians adapted the instructional content to an audience of graduate students in the College of Public Health and Health Professions. Methods: The basic science version of the course covered literature searching, bibliographic citation software, basic NCBI resources, funding sources, data management, and information ethics. In transforming the class for health professional students, librarians replaced the genetic and genomic resources sessions with introductory sessions on systematic reviews and grey literature. Conceptual material fit mapped well to the Association of College and Research Libraries (ACRL) Information Literacy Framework. Health professions PhD program coordinators provided feedback on the syllabus and helped inform students about the course. Results: Formal student evaluation data is not yet available; however, informal feedback indicated that the course was incredibly valuable for doctoral students; one student even suggested making the course required. Student quiz scores and class discussion revealed that the choice of topics resonated with students, captured their interests, and fulfilled a need not met by their other courses. Conclusions: Developing and teaching a credit-bearing graduate course on information-related topics is one mechanism for librarians to further integrate into the curricula of their programs and broaden their reach. A course that has been developed and approved by a specific campus unit may prove relevant to other units and easily customized to fit their needs, thus increasing its impact

The Iowa Homemaker vol.7, no.1

Table of Contents Modern Dress – Controversial Article, page 1 What’s In a Name? by Marcia E. Turner, page 2 Helps for the Spring Market Basket by Margaret L. Marnette, page 3 Lacquer for Ktichen Tables by Della J. Norton, page 3 A Pressure or a Fireless Cooker – Which? by Ethel Cessna Morgan, page 4 4-H Page, page 6 Iowa State Home Economics Association Page, page 8 News Notes, page 10 Editorial, page 11 Who’s There and Where, page 12 The Children’s Hour by Mary E. Moser, page 14 Hammer, Saw, Paint Brush and Nerve by Eleanor Baur, page 15 Had Your Iron Today?, page 1

Socioeconomic Mediators of Racial and Ethnic Disparities in Congenital Heart Disease Outcomes: A Population-Based Study in California.

Background Racial/ethnic and socioeconomic disparities exist in outcomes for children with congenital heart disease. We sought to determine the influence of race/ethnicity and mediating socioeconomic factors on 1-year outcomes for live-born infants with hypoplastic left heart syndrome and dextro-Transposition of the great arteries. Methods and Results The authors performed a population-based cohort study using the California Office of Statewide Health Planning and Development database. Live-born infants without chromosomal anomalies were included. The outcome was a composite measure of mortality or unexpected hospital readmissions within the first year of life defined as >3 (hypoplastic left heart syndrome) or >1 readmissions (dextro-Transposition of the great arteries). Hispanic ethnicity was compared with non-Hispanic white ethnicity. Mediation analyses determined the percent contribution to outcome for each mediator on the pathway between race/ethnicity and outcome. A total of 1796 patients comprised the cohort (n=964 [hypoplastic left heart syndrome], n=832 [dextro-Transposition of the great arteries]) and 1315 were included in the analysis (n=477 non-Hispanic white, n=838 Hispanic). Hispanic ethnicity was associated with a poor outcome (crude odds ratio, 1.72; 95% confidence interval [CI], 1.37-2.17). Higher maternal education (crude odds ratio 0.5; 95% CI , 0.38-0.65) and private insurance (crude odds ratio, 0.65; 95% CI , 0.45-0.71) were protective. In the mediation analysis, maternal education and insurance status explained 33.2% (95% CI , 7-66.4) and 27.6% (95% CI , 6.5-63.1) of the relationship between race/ethnicity and poor outcome, while infant characteristics played a minimal role. Conclusions Socioeconomic factors explain a significant portion of the association between Hispanic ethnicity and poor outcome in neonates with critical congenital heart disease. These findings identify vulnerable populations that would benefit from resources to lessen health disparities

Perspectives of US private payers on insurance coverage for pediatric and prenatal exome sequencing: Results of a study from the Program in Prenatal and Pediatric Genomic Sequencing (P3EGS).

PurposeExome sequencing (ES) has the potential to improve management of congenital anomalies and neurodevelopmental disorders in fetuses, infants, and children. US payers are key stakeholders in patient access to ES. We examined how payers view insurance coverage and clinical utility of pediatric and prenatal ES.MethodsWe employed the framework approach of qualitative research to conduct this study. The study cohort represented 14 payers collectively covering 170,000,000 enrollees.ResultsSeventy-one percent of payers covered pediatric ES despite perceived insufficient evidence because they saw merit in available interventions or in ending the diagnostic odyssey. None covered prenatal ES, because they saw no merit. For pediatric ES, 50% agreed with expanded aspects of clinical utility (e.g., information utility), and 21% considered them sufficient for coverage. For prenatal ES, payers saw little utility until in utero interventions become available.ConclusionThe perceived merit of ES is becoming a factor in payers' coverage for serious diseases with available interventions, even when evidence is perceived insufficient. Payers' views on ES's clinical utility are expanding to include informational utility, aligning with the views of patients and other stakeholders. Our findings inform clinical research, patient advocacy, and policy-making, allowing them to be more relevant to payers