844 research outputs found
The 4-H Summer Cultural Arts Day Camp: Bringing The World to My World
This article describes a community-based 4-H Cultural Arts Day Camp designed to address the out of school time needs of youth in a rural, isolated area. The camp was conducted in collaboration with several local agencies and the Oregon State University Extension Service, and is intended to provide intercultural awareness through the artistic exploration of various world cultures. An evaluation of the camp in 2003 concluded that participating youth were actively learning about other cultures. The camp clearly meets an important need, both in terms of raising intercultural awareness and providing much needed summer opportunities for rural youth
Predoctoral Interns\u27 Nondisclosure in Supervision
In interviews with 14 counseling center predoctoral interns regarding a significant nondisclosure in supervision, eight interns reported good supervisory relationships and six indicated that they experienced problematic supervisory relationships. Nondisclosures for the interns in good supervisory relationships related to personal reactions to clients, whereas nondisclosures for interns in problematic supervisory relationships related to global dissatisfaction with the supervisory relationship. In both groups, interns mentioned concerns about evaluation and negative feelings as typical reasons for nondisclosure. Additional reasons for nondisclosure for interns in problematic supervision were power dynamics, inhibiting demographic or cultural variables, and the supervisor\u27s theoretical orientation. Both groups described negative effects of nondisclosure on themselves and their relationships with clients. Interns in problematic supervision also reported that nondisclosures had negative effects on the supervisory relationship
Agreement of direct antifungal susceptibility testing from positive blood culture bottles with the conventional method for candida species
Early availability of antifungal susceptibilities can ensure timely institution of targeted therapy in candidemia, which can improve patient outcomes. This study prospectively determines the agreement between the results of direct testing of antifungal susceptibilities from blood culture bottles by disk diffusion and Etest and the results of standardized susceptibility testing methods; direct testing would allow susceptibility results to be available 1 to 2 days earlier. A total of 104 blood cultures with different Candida species (28% C. albicans, 27% C. parapsilosis, 26% C. tropicalis, etc.) were evaluated between January 2012 and May 2013 for agreement of fluconazole, voriconazole, and amphotericin B susceptibility results by disk diffusion. Agreement in MICs obtained by Etest was determined for fluconazole (21 isolates), voriconazole (28 isolates), amphotericin (29 isolates), and caspofungin (29 isolates). The kappa scores for categorical agreement were highest for fluconazole by disk diffusion (0.902, standard error [SE] = 0.076) and Etest (1.00, SE = 0.218) and for amphotericin B by disk diffusion (1.00, SE = 0.098). The Pearson correlation (r) of zone diameters was strongest for fluconazole (0.69) and amphotericin (0.70) and moderate for voriconazole (0.60), and the Pearson correlation of MICs was strongest for fluconazole (0.94) and caspofungin (0.88). However, the moderate correlation of amphotericin MICs with zone diameters (−0.42) precludes the use of amphotericin B disk diffusion for susceptibility testing. There were no very major errors; however, there were 1 (1%) major and 5 (4.8%) minor errors with disk diffusion and 4 (13.3%) minor errors with Etest. Thus, antifungal disk diffusion directly from blood culture bottles is a rapid and easy method for fluconazole and voriconazole susceptibility testing for timely tailoring of candidemia therapy
Conceptual Design of the Coronagraphic High Angular Resolution Imaging Spectrograph (CHARIS) for the Subaru Telescope
Recent developments in high-contrast imaging techniques now make possible
both imaging and spectroscopy of planets around nearby stars. We present the
conceptual design of the Coronagraphic High Angular Resolution Imaging
Spectrograph (CHARIS), a lenslet-based, cryogenic integral field spectrograph
(IFS) for imaging exoplanets on the Subaru telescope. The IFS will provide
spectral information for 140x140 spatial elements over a 1.75 arcsecs x 1.75
arcsecs field of view (FOV). CHARIS will operate in the near infrared (lambda =
0.9 - 2.5 microns) and provide a spectral resolution of R = 14, 33, and 65 in
three separate observing modes. Taking advantage of the adaptive optics systems
and advanced coronagraphs (AO188 and SCExAO) on the Subaru telescope, CHARIS
will provide sufficient contrast to obtain spectra of young self-luminous
Jupiter-mass exoplanets. CHARIS is in the early design phases and is projected
to have first light by the end of 2015. We report here on the current
conceptual design of CHARIS and the design challenges
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Longitudinal Medication Usage in Alzheimer Disease Patients
This study examined in detail patterns of cholinesterase inhibitors (ChEIs) and memantine use and explored the relationship between patient characteristics and such use. Patients with probable Alzheimer disease AD (n=201) were recruited from the Predictors Study in 3 academic AD centers and followed from early disease stages for up to 6 years. Random effects logistic regressions were used to examine effects of patient characteristics on ChEIs/memantine use over time. Independent variables included measures of function, cognition, comorbidities, the presence of extrapyramidal signs, psychotic symptoms, age, sex, and patient's living situation at each interval. Control variables included assessment interval, year of study entry, and site. During a 6-year study period, rate of ChEIs use decreased (80.6% to 73.0%) whereas memantine use increased (2.0% to 45.9%). Random effects logistic regression analyses showed that ChEI use was associated with better function, no psychotic symptoms, and younger age. Memantine use was associated with better function, poorer cognition, living at home, later assessment interval, and later year of study entry. Results suggest that high rate of ChEI use and increasing memantine use over time are consistent with current practice guidelines of initiation of ChEIs in mild-to-moderate AD patients and initiation of memantine in moderate-to-severe patients
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Utilization of Antihypertensives, Antidepressants, Antipsychotics, and Hormones in Alzheimer Disease
This study explores the longitudinal relationship between patient characteristics and use of 4 drug classes (antihypertensives, antidepressants, antipsychotics, and hormones) that showed significant changes in use rates over time in patients with Alzheimer disease. Patient/caregiver-reported prescription medication usage was categorized by drug class for 201 patients from the Predictors Study. Patient characteristics included use of cholinesterase inhibitors and/or memantine, function, cognition, living situation, baseline age, and sex. Assessment interval, year of study entry, and site were controlled for. Before adjusting for covariates, useage increased for antihypertensives (47.8% to 62.2%), antipsychotics (3.5% to 27.0%), and antidepressants (32.3% to 40.5%); use of hormones decreased (19.4% to 5.4%). After controlling for patient characteristics, effects of time on the use of antidepressants were no longer significant. Antihypertensive use was associated with poorer functioning, concurrent use of memantine, and older age. Antipsychotic use was associated with poorer functioning and poorer cognition. Antidepressant use was associated with younger age, poorer functioning, and concurrent use of cholinesterase inhibitors and memantine. Hormone use was associated with being female and younger age. Findings suggest accurate modeling of the Alzheimer disease treatment paradigm for certain subgroups of patients should include antihypertensives and antipsychotics in addition to cholinesterase inhibitors and memantine
The Ionized Gas and Nuclear Environment in NGC 3783 V. Variability and Modeling of the Intrinsic Ultraviolet Absorption
We present results on the location, physical conditions, and geometry of the
outflow in the Seyfert 1 galaxy NGC 3783 from a study of the variable intrinsic
UV absorption. Based on 18 observations with HST/STIS and 6 observations with
FUSE, we find: 1) The absorption from the lowest-ionization species in each of
the three strong kinematic components varied inversely with the continuum flux,
indicating the ionization structure responded to changes in the photoionizing
flux over the weekly timescales sampled by our observations. 2) A multi-
component model with an unocculted NLR and separate BLR and continuum
line-of-sight covering factors predicts saturation in several lines, consistent
with the lack of observed variability. 3) Column densities for the individual
metastable levels are measured from the resolved C III *1175 absorption complex
observed in one component. Based on our computed metastable level populations,
the electron density of this absorber is ~3x10^4 cm^-3. Photoionization
modeling results place it at ~25 pc from the central source. 4) Using
time-dependent calculations, we are able to reproduce the detailed variability
observed in this absorber, and derive upper limits on the distances for the
other components of 25-50 pc. 5) The ionization parameters derived for the
higher ionization UV absorbers are consistent with the modeling results for the
lowest-ionization X-ray component, but with smaller total column density. They
have similar pressures as the three X-ray ionization components. These results
are consistent with an inhomogeneous wind model for the outflow in NGC 3783. 6)
Based on the predicted emission-line luminosities, global covering factor
constraints, and distances derived for the UV absorbers, they may be identified
with emission- line gas observed in the inner NLR of AGNs. (abridged)Comment: 30 pages, 18 figures (7 color), emulateapj, accepted for publication
in The Astrophysical Journa
Consensus in Guidelines for Evaluation of DSD by the Texas Children's Hospital Multidisciplinary Gender Medicine Team
The Gender Medicine Team (GMT), comprised of members with expertise in endocrinology, ethics, genetics, gynecology, pediatric surgery, psychology, and urology, at Texas Children's Hospital and Baylor College of Medicine formed a task force to formulate a consensus statement on practice guidelines for managing disorders of sexual differentiation (DSD) and for making sex assignments. The GMT task force reviewed published evidence and incorporated findings from clinical experience. Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence presented in the literature for establishing evidence-based guidelines. The task force presents a consensus statement regarding specific diagnostic and therapeutic issues in the management of individuals who present with DSD. The consensus statement includes recommendations for (1) laboratory workup, (2) acute management, (3) sex assignment in an ethical framework that includes education and involvement of the parents, and (4) surgical management
CHARIS Science: Performance Simulations for the Subaru Telescope's Third-Generation of Exoplanet Imaging Instrumentation
We describe the expected scientific capabilities of CHARIS, a high-contrast
integral-field spectrograph (IFS) currently under construction for the Subaru
telescope. CHARIS is part of a new generation of instruments, enabled by
extreme adaptive optics (AO) systems (including SCExAO at Subaru), that promise
greatly improved contrasts at small angular separation thanks to their ability
to use spectral information to distinguish planets from quasistatic speckles in
the stellar point-spread function (PSF). CHARIS is similar in concept to GPI
and SPHERE, on Gemini South and the Very Large Telescope, respectively, but
will be unique in its ability to simultaneously cover the entire near-infrared
, , and bands with a low-resolution mode. This extraordinarily broad
wavelength coverage will enable spectral differential imaging down to angular
separations of a few , corresponding to 0.\!\!''1. SCExAO
will also offer contrast approaching at similar separations,
0.\!\!''1--0.\!\!''2. The discovery yield of a CHARIS survey will
depend on the exoplanet distribution function at around 10 AU. If the
distribution of planets discovered by radial velocity surveys extends unchanged
to 20 AU, observations of 200 mostly young, nearby stars targeted
by existing high-contrast instruments might find 1--3 planets. Carefully
optimizing the target sample could improve this yield by a factor of a few,
while an upturn in frequency at a few AU could also increase the number of
detections. CHARIS, with a higher spectral resolution mode of , will
also be among the best instruments to characterize planets and brown dwarfs
like HR 8799 cde and And b.Comment: 13 pages, 7 figures, proceedings from SPIE Montrea
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