114 research outputs found

    Letter to Philander Chase

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    Mary Caswell tells her uncle Philander Chase about her life in England. She now has four children, the youngest having been born in December. She asks Chase if an eighth number of Reminiscences has been published yet, as she and her family enjoyed reading them all, particularly the seventh.https://digital.kenyon.edu/chase_letters/2243/thumbnail.jp

    Santos: Religious Folk Art of New Mexico, 1750 to 1850

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    This study was begun out of a sincere love for the art of the santos. It will cover the santos' beginnings in New Mexico around 1750 and discuss the historical causes for both the santos' rise to popularity and their later demise. This study will attempt to cover all of the factors that had an effect on their creation and style and to discuss what the santos' contribution to folk art in America might be.Housing, Design, and Consumer Resource

    Evolution of nest architecture in tyrant flycatchers and allies

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    This study was funded by Princeton University, a Packard Fellowship for Science and Engineering (to M.C.S.), AFOSR FA9550-20-1-0161 (to M.C.S.), Eric and Wendy Schmidt by recommendation of the Schmidt Futures Polymaths program (to M.C.S.), and European Research Council Advanced Grant 788203. Acknowledgements We would like to thank Karina Vanadzina for sharing unpublished life-history data and Maria Camila LeĆ³n for providing original artwork. Maria E. Mendiwelso Moreno helped to gather information from the literature for some species and Gates Dupont provided insights about statistical analysis in the earliest stages of the project. Mark Mainwaring and two reviewers provided very insightful comments that have improved our manuscript. Photographs were obtained with permission from Daniel Field, Daniel Perrella, John and Milena Beer, Gustavo LondoƱo and Juan Felipe LeĆ³n. We are indebted to the many field biologists who described the nests of Tyrannida species.Peer reviewedPublisher PD

    Rab-coupling protein coordinates recycling of Ī±5Ī²1 integrin and EGFR1 to promote cell migration in 3D microenvironments

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    Here we show that blocking the adhesive function of Ī±vĪ²3 integrin with soluble RGD ligands, such as osteopontin or cilengitide, promoted association of Rab-coupling protein (RCP) with Ī±5Ī²1 integrin and drove RCP-dependent recycling of Ī±5Ī²1 to the plasma membrane and its mobilization to dynamic ruffling protrusions at the cell front. These RCP-driven changes in Ī±5Ī²1 trafficking led to acquisition of rapid/random movement on two-dimensional substrates and to a marked increase in fibronectin-dependent migration of tumor cells into three-dimensional matrices. Recycling of Ī±5Ī²1 integrin did not affect its regulation or ability to form adhesive bonds with substrate fibronectin. Instead, Ī±5Ī²1 controlled the association of EGFR1 with RCP to promote the coordinate recycling of these two receptors. This modified signaling downstream of EGFR1 to increase its autophosphorylation and activation of the proinvasive kinase PKB/Akt. We conclude that RCP provides a scaffold that promotes the physical association and coordinate trafficking of Ī±5Ī²1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices

    A Partial Albino Hatchling Northern Ring-necked Snake, Diadophis punctatus edwardsii, from Big Tancook Island, Mahone Bay, Lunenburg County, Nova Scotia, Canada

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    On 10 June 2012 a sample of seven gravid female Northern Ring-necked Snakes (Diadophis punctatus edwardsii), from Big Tancook Island, Lunenburg County, Nova Scotia, was selected for a seasonal live display at the Nova Scotia Museum of Natural History in Halifax. A total of 13 eggs was removed from the display in late June 2012 and incubated for public viewing. The eggs began hatching on 22 August 2012. One of the hatchlings was partial albino (with zanthophores or amelanistic). This is the first record of an albinistic Northern Ring-necked Snake in Nova Scotia

    NASAwide electronic publishing system: Prototype STI electronic document distribution, stage-4 evaluation report

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    This evaluation report contains an introduction, seven chapters, and five appendices. The Introduction describes the purpose, conceptual frame work, functional description, and technical report server of the STI Electronic Document Distribution (EDD) project. Chapter 1 documents the results of the prototype STI EDD in actual operation. Chapter 2 documents each NASA center's post processing publication processes. Chapter 3 documents each center's STI software, hardware, and communications configurations. Chapter 7 documents STI EDD policy, practices, and procedures. The appendices, which arc contained in Part 2 of this document, consist of (1) STI EDD Project Plan, (2) Team members, (3) Phasing Schedules, (4) Accessing On-line Reports, and (5) Creating an HTML File and Setting Up an xTRS. In summary, Stage 4 of the NASAwide Electronic Publishing System is the final phase of its implementation through the prototyping and gradual integration of each NASA center's electronic printing systems, desktop publishing systems, and technical report servers to be able to provide to NASA's engineers, researchers, scientists, and external users the widest practicable and appropriate dissemination of information concerning its activities and the result thereof to their work stations
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