Unconstraining Graph-Constrained Group Testing

In network tomography, one goal is to identify a small set of failed links in a network using as little information as possible. One way of setting up this problem is called graph-constrained group testing. Graph-constrained group testing is a variant of the classical combinatorial group testing problem, where the tests that one is allowed are additionally constrained by a graph. In this case, the graph is given by the underlying network topology. The main contribution of this work is to show that for most graphs, the constraints imposed by the graph are no constraint at all. That is, the number of tests required to identify the failed links in graph-constrained group testing is near-optimal even for the corresponding group testing problem with no graph constraints. Our approach is based on a simple randomized construction of tests. To analyze our construction, we prove new results about the size of giant components in randomly sparsified graphs. Finally, we provide empirical results which suggest that our connected-subgraph tests perform better not just in theory but also in practice, and in particular perform better on a real-world network topology

Circular 68

Livestock rations should be balanced for many parameters including protein, and various minerals, and energy, to ensure that all required nutrients are present in the adequate amounts and proper relationships. Energy content is the primary consideration for balancing any farm animal’s diet because it is often the most limiting factor in animal performance. In Alaska, it is extremely important to test for major nutrients and then to balance rations because: 1) Alaska has longer, colder and wetter winters than those in the lower 48 states and consequently Alaskan animals have different nutrient needs. 2) Alaskan feedstuffs tend to be more variable in nutrient content than feeds grown in other states. After energy requirements, crude protein, calcium, phosphorus, and potassium are considered - and with the energy estimate - are the basis of the standard feed analyses performed by the Agricultural and Forestry Experiment Station (AFES) Service Laboratory feed testing section. Because all of these nutrients can vary greatly in the same feed, the Palmer Animal Sciences beef unit of AFES tracks the nutrient values of feed samples submitted to the AFES Service Laboratory. A summary of these values provides an indication of the types and values of feed available in Alaska. It also shows the variability in nutrient content of feedstuffs. Hopefully, this will stimulate the use of individual nutrient analyses for feeding livestock in Alaska

School Counselors\u27 Perceptions about lnterventions for At-Risk Students Including Grade Retention: Implications for School Leaders

The term at-risk is used by educators and policymakers to describe a wide variety of students who struggle in schools (Kronholz, 2011). Factors associated with labeling students at-risk include minority status, poverty, language difficulties, low school attendance, and poor family support (Re~ Akpo-Sanni, Losike-Sedimo, 2012; Stockard, 2010). For many at-risk students, reading at a proficient level is a primary concern for school leaders and teachers (Allington, 2011; McAlenney & Coyne, 2011), especially with increased accountability including school sanctions for not closing reading achievement gaps (Chappell, Nunnery, Pribesh, & Hager, 2011). Although a plethora of interventions have been proposed to assist at-risk students, requiring students to repeat a grade continues to be used as a threat for students who are not proficient, despite evidence that suggests grade retention is detrimental to students on various outcomes (Battistin & Schizzerotto, 2012; Webley, 2012)

No. 05: The HIV and Urban Food Security Nexus

Considerable attention has been devoted to the impact of the HIV and AIDS epidemic on small farmers and the food security of the rural poor. Despite the rapid progression of the epidemic in rural areas, it remains an ever-growing challenge in the continent’s rapidly-growing cities where prevalence rates are still higher than in rural areas. This report examines the reciprocal relationship between HIV and urban food security. Much of the research and most of the policy interventions on the HIV-Urban Food Security Nexus focus on the nutritional status of individual People Living With HIV (PLHIV). Other members of households with PLHIV also experience an increase in food insecurity as household purchasing power declines and nutritional needs increase. Urban food insecurity is a complex phenomenon and nutritional research and interventions on the vicious circle of HIV and nutrition need to be reframed within a broader socio-economic perspective that encompasses all of the various aspects of urban food security

Activation of type II calcium/calmodulin-dependent protein kinase by Ca^(2+)/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain

It is now well established that autophosphorylation of a threonine residue located next to each calmodulin-binding domain in the subunits of type II Ca^(2+)/calmodulin-dependent protein kinase causes the kinase to remain active, although at a reduced rate, after Ca^(2+) is removed from the reaction. This autophosphorylated form of the kinase is still sensitive to Ca2+/calmodulin, which is required for a maximum catalytic rate. After removal of Ca^(2+), new sites are autophosphorylated by the partially active kinase. Autophosphorylation of these sites abolishes sensitivity of the kinase to Ca^(2+)/calmodulin (Hashimoto, Y., Schworer, C. M., Colbran, R. J., and Soderling, T. R. (1987) J. Biol. Chem. 262, 8051-8055). We have identified two pairs of homologous residues, Thr^(305) and Ser^(314) in the alpha subunit and Thr^(306) and Ser^(315) in the beta subunit, that are autophosphorylated only after removal of Ca^(2+) from an autophosphorylation reaction. The sites were identified by direct sequencing of labeled tryptic phosphopeptides isolated by reverse-phase high pressure liquid chromatography. Thr^(305-306) is rapidly dephosphorylated by purified protein phosphatases 1 and 2A, whereas Ser^(314-315) is resistant to dephosphorylation. We have shown by selective dephosphorylation that the presence of phosphate on Thr^(305-306) blocks sensitivity of the kinase to Ca^(2+)/calmodulin. In contrast, the presence of phosphate on Ser^(314-315) is associated with an increase in the Kact for Ca^(2+)/calmodulin of only about 2-fold, producing a relatively small decrease in sensitivity to Ca^(2+)/calmodulin

Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned

Background Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the ‘gold standard’ management system developed for managing diverse operations in major incident and public health arenas. It enables effective and flexible management through integration of personnel, procedures, resources, and communications within a common hierarchical organisational structure. Conventional ICS organisation consists of five function modules: Command, Planning, Operations, Logistics, and Finance/Administration. Large clinical trials will require a separate Regulatory Administrative arm, and an Information arm, consisting of dedicated data management and information technology staff. We applied ICS principles to organisation and management of the Prehospital Use of Plasma in Traumatic Haemorrhage (PUPTH) trial. This trial was a multidepartmental, multiagency, randomised clinical trial investigating prehospital administration of thawed plasma on mortality and coagulation response in severely injured trauma patients. We describe the ICS system as it would apply to large clinical trials in general, and the benefits, barriers, and lessons learned in utilising ICS principles to reorganise and coordinate the PUPTH trial. Results Without a formal trial management structure, early stages of the trial were characterised by inertia and organisational confusion. Implementing ICS improved organisation, coordination, and communication between multiple agencies and service groups, and greatly streamlined regulatory compliance administration. However, unfamiliarity of clinicians with ICS culture, conflicting resource allocation priorities, and communication bottlenecks were significant barriers. Conclusions ICS is a flexible and powerful organisational tool for managing large complex clinical trials. However, for successful implementation the cultural, psychological, and social environment of trial participants must be accounted for, and personnel need to be educated in the basics of ICS

Access to Hospice Care: Expanding Boundaries, Overcoming Barriers

This report looks at issues of social justice, access, and public policy in hospice and palliative care. As it examines the issues from the perspectives of social justice and fairness, it also recommends ways in which the definition of hospice can be expanded to include more Americans for a longer period of time than simply the days or months shortly before death

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic

This fourth annual update on America's high school dropout crisis shows that for the first time the nation is on track to meet the goal of a 90 percent high school graduation rate by the Class of 2020 -- if the pace of improvement from 2006 to 2010 is sustained over the next 10 years. The greatest gains have occurred for the students of color and low-income students most affected by the dropout crisis. Many schools, districts and states are making significant gains in boosting high school graduation rates and putting more students on a path to college and a successful career. This progress is often the result of having better data, an understanding of why and where students drop out, a heightened awareness of the consequences to individuals and the economy, a greater understanding of effective reforms and interventions, and real-world examples of progress and collaboration. These factors have contributed to a wider understanding that the dropout crisis is solvable.While progress is encouraging, a deeper look at the data reveals that gains in graduation rates and declines in dropout factory high schools occurred unevenly across states and subgroups of students (e.g. economically disadvantaged, African American, Hispanic, students with disabilities, and students with limited English proficiency). As a result, large "graduation gaps" remain in many states among students of different races, ethnicities, family incomes, disabilities and limited English proficiencies. To repeat the growth in graduation rates in the next ten years experienced in the second half of the last decade, and to ensure progress for all students, the nation must turn its attention to closing the graduation gap by accelerating progress for student subgroups most affected by the dropout crisis.This report outlines the progress made and the challenges that remain. Part 1: The Data analyzes the latest graduation rates and "dropout factory" trends at the state and national levels. Part 2: Progress and Challenge provides an update on the nation's shared efforts to implement the Civic Marshall Plan to reach the goal of at least a 90 percent high school graduation rate for the Class of 2020 and all classes that follow. Part 3: Paths Forward offers recommendations on how to accelerate our work and achieve our goals, with all students prepared for college and career. The report also offers "snapshots" within schools, communities, and organizations from Orlando to Oakland that are making substantial gains in boosting high school graduation rates

Economic Statistics and U.S. Agricultural Policy

Economic statistics can be used to inform policy as it is being designed, avoid policy design mistakes, or implement government programs once they are established into law. Oftentimes, statistics are used for all three purposes. This paper considers the relationships between statistics and agricultural policy in the case of the United States. We address first the broad historical picture of U.S. official economic statistics concerning agriculture, and then turn to selected examples that relate policies to economic statistics in more detail. The examples show diversity in the interplay between statistics and policy. As policies have become broader in scope, addressing not only farm commodity markets but also differences among farms and a widening set of activities on farms, policymakers have asked for more detailed information about the financial situation of individual farm businesses and households, sources of risk in farm returns, and production practices that affect the environment.Agricultural policy, Data collection and estimation, Economic history of U.S. agriculture, Agricultural and Food Policy, Q18, C8, N52,