The Constitutional Status of Women in 1787

Women and the Constitution: Presentation from the 1987 Eighth Circuit Judicial Conference, Colorado Springs, Colorado July 17, 1987: Panel Presentation

George Burroughs and The Girls From Casco: The Maine Roots of Salem Witchcraft

Although few hooks about the Salem witchcraft crisis of 1692 have paid much attention to him, the Reverend George Burroughs (who was accused in April, examined in May; and convicted and hanged in August) was the key figure in the episode, along with three young women who numbered among his principal accusers: Mercy Lewis, Susannah Sheldon, and Abigail Hobbs. All four lived in Maine for far longer than they resided in Salem Village. Burroughs spent most of his ministerial career in Falmouth (Portland), Black Point (Scarborough), and Wells; Lewis was born and raised in Falmouth, where Hobbs spent most of her childhood; and Sheldon was born and raised in Black Point. All fled the frontier during the Maine Indian wars. Their crucial roles in the witchcraft crisis inextricably link that iconic episode to events on the Maine frontier during King Philip\u27s and King William\u27s Wars. Mary Beth Norton is the Mary Donlon Alger Professor of American History at Cornell University. This essay is taken from her latest book, In the Devil’s Snare: The Salem Witchcraft Crisis of 1692

The Constitutional Status of Women in 1787

Women and the Constitution: Presentation from the 1987 Eighth Circuit Judicial Conference, Colorado Springs, Colorado July 17, 1987: Panel Presentation

Readers\u27 Speakout

Dear Ms. Howe: In a paper called Lesbian Perspectives on Women\u27s Studies, presented at the National Women\u27s Studies Association\u27s 1980 Convention, Marilyn Frye, professor of philosophy at Michigan State University, said that in her judgment the field of women\u27s studies is heterosexual. This paper has served as a springboard for discussion among the professors and students who comprise the Women\u27s Studies Advisory Committee at the University of Illinois at Urbana-Champaign. Across the country a division between heterosexuals and homosexuals in women\u27s studies is being generated. In a sense we at the University of Illinios at Urbana-Champaign are blessed that this has yet to become a divisive issue; however , we are seeking means to avoid divisiveness. We feel that simply to include a section on homosexuality within a particular course is no more appropriate or satisfactory than it is merely to include a section on women within a course in a particular subject

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development

A People and A Nation

xxiii.1019 hal.;ill.;26 c