Screening for Bulimia Nervosa in the Primary Care Setting: Educating Healthcare Providers on the use of the Most Valid and Reliable Screening Tools

Abstract There are currently no routine screening guidelines for eating disorders in the primary care setting, despite their high mortality rate. Bulimia Nervosa (BN) is one of the hardest eating disorders to diagnose due to the lack of physical features and its secretive nature. Primary care providers need to have knowledge of the most valid and reliable screening tools in order to better diagnose and treat BN. In order to assess the most valid and reliable screening tools for BN, current literature was appraised with the focus on tools specifically designed for detection of BN. The results of the literature were translated into an educational tool and presented to healthcare team members at a pediatric primary care office in Burlington, Vermont. Pre and post-presentation questionnaires were distributed to attendees to gauge current knowledge around BN screening tools and gauge the efficacy of the presentation

Reading, writing, and metacognition: Theoretical connections and teaching methods

Relationships between reading and writing -- Formation of a thought-world that is a cluster of ideas and associations related to a literacy event -- Establishment of a progression of interrelated ideas from the thought-world -- Creation of intersentence cohesion by filling of gaps

Developing the Yeast Disaggregase Hsp104 as a Treatment for Polyglutamine Disease in Drosophila

There is currently no cure for neurodegenerative disease or the underlying burden of protein aggregation that is associated with symptom development. A novel approach to combat this accumulation of misfolded protein species is surprisingly found in a protein disaggregase in yeast, the heat shock protein Hsp104. To investigate whether Hsp104 can be introduced into an animal system and harnessed to attack disease-associated protein inclusions, we created a transgenic Drosophila model expressing Hsp104 and investigated whether this would mitigate toxicity and alter the load of protein accumulations. We found that Hsp104 indeed suppressed toxicity of a disease-associated protein fragment containing an expanded polyglutamine tract. However, we found that Hsp104 worsened toxicity of the full-length pathogenic polyglutamine protein, and this coincided with increased accumulation of amyloid inclusions. This aberrant activity of Hsp104 depended on intact domains in the non-polyglutamine stretches of the protein, and this negative interaction could be prevented by mutation to these neighboring domains. These results indicate that knowing the precise protein state of a disease environment is critical in evaluating potential therapeutics. Moreover, we sequentially activated Hsp104 after the onset of protein aggregation and start of tissue degeneration, to find that Hsp104, but not Hsp70, significantly suppressed progressive degeneration. Thus, the unique ability of Hsp104 to tackle pre-existing amyloid conformers may offer a novel opportunity to reverse disease progression once underway

Associations of Abdominal Muscle Area and Radiodensity with Adiponectin and Leptin: The Multiethnic Study of Atherosclerosis.

ObjectiveThis study examined the associations of muscle area and radiodensity with adiponectin and leptin.MethodsA total of 1,944 participants who enrolled in the Multi-Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin-6, C-reactive protein, and resistin.ResultsThe mean age and BMI of participants were 64.7 years and 28.1 kg/m2 and 49% were female. With adjustment for age, gender, race/ethnicity, traditional cardiovascular disease risk factors, inflammatory biomarkers, physical activity, and sedentary behavior, a 1-SD increment in total abdominal, stability, and locomotor muscle area was associated with a 19%, 17%, and 12% lower adiponectin level, respectively (P < 0.01 for all) but not leptin (P > 0.05). Muscle radiodensity was more robustly associated with adiponectin and leptin in the multivariable linear regression models. That is, with full adjustment for all covariates, a 1-SD increment in total abdominal, stability, and locomotor muscle radiodensity was associated with a 31%, 31%, and 18% lower adiponectin level (P < 0.01 for all) and a 6.7%, 4.6%, and 8.1% higher leptin level (P < 0.05 for all), respectively.ConclusionsThe data suggest that increases in muscle area and radiodensity may have positive impacts on chronic inflammation and, in turn, reduce the risk of cardiometabolic disease

A Public Health Side Effect of the Coronavirus Pandemic: Screen Time-Related Eye Strain and Eye Fatigue

Has your screen use increased since the start of COVID-19? You’re not alone. COVID-19 social distancing and stay-at-home orders have increased the time we are spending looking at screens. While these technologies help us stay connected and enable us to get the resources we need, too much screen time can lead to eye strain, headaches, and neck and back pain

2010-2011 Drake Memorial Library Annual Report

The 2010-2011 annual report of Drake Memorial Library of The College at Brockport, as compiled by Mary Jo Orzech, Bob Cushman, Pam O\u27Sullivan and Jennifer Smathers with contributions from the Drake Faculty and Staff

2009-2010 Drake Memorial Library Annual Report

The 2009-2010 annual report of Drake Memorial Library of The College at Brockport, as compiled by Mary Jo Orzech, Bob Cushman, Pam O\u27Sullivan and Jennifer Smathers with contributions from the Drake Faculty and Staff

2012-2013 Drake Memorial Library Annual Report

The 2012-2013 annual report of Drake Memorial Library of The College at Brockport, as compiled by Mary Jo Orzech, Bob Cushman, Pam O\u27Sullivan and Jennifer Smathers with contributions from the Drake Faculty and Staff