Senator Edmund S. Muskie Interviewed by Marvin Kalb About Publication of Government Documents on Vietnam

CBS correspondent Marvin Kalb interview of Senator Edmund S. Muskie on the issue of the publication of government documents on Vietnam obtained by the New York Times

The New American Gazette: Ayn Rand “Apollo (11) and Dionysus (at Woodstock), at Ford Hall Forum, transcript

Ayn Rand provides a detailed analysis of two major event of the sixties -- the Woodstock music festival and the Apollo 11 spaceflight in a forum entitled, “Apollo (11) and Dionysus (at Woodstock).” The forum was originally recorded on November 9, 1969 and rebroadcast as part of the New American Gazette radio program on March 1 1990. The radio broadcast is introduced by host Marvin Kalb.https://dc.suffolk.edu/fhf-av/1000/thumbnail.jp

The New American Gazette: An Evening with Robert Frost at Ford Hall Forum, transcript

Robert Frost, a Pulitzer Prize winning American poet, addresses his views of America through readings of his poetry. The forum was originally recorded in 1961 and rebroadcast as part of the New American Gazette radio program on March 22, 1990. The radio broadcast is introduced by host Marvin Kalb.https://dc.suffolk.edu/fhf-av/1001/thumbnail.jp

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for Parkinson's disease (PD). Here, we employ global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell (iPSC)-derived neurons and midbrain organoids to dissect the mechanisms underlying GCase-related neurodegeneration. We demonstrate that GCase can be imported from the cytosol into the mitochondria via recognition of internal mitochondrial targeting sequence-like signals. In mitochondria, GCase promotes the maintenance of mitochondrial complex I (CI) integrity and function. Furthermore, GCase interacts with the mitochondrial quality control proteins HSP60 and LONP1. Disease-associated mutations impair CI stability and function and enhance the interaction with the mitochondrial quality control machinery. These findings reveal a mitochondrial role of GCase and suggest that defective CI activity and energy metabolism may drive the pathogenesis of GCase-linked neurodegeneration

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Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk