Thermosensitive Magnetic Nanoparticles for Self-Controlled Hyperthermia Cancer Treatment

Magnetic nanoparticles show remarkable phenomena such as superparamagnetism, high field irreversibility and high saturation magnetization [1]. The study of magnetic nanoparticles has been a very active research field due to many important applications such as drug delivery, imaging and hyperthermia cancer treatment [2]. Hyperthermia has been used for many years to treat a wide variety of tumors in patients and used as well as an adjunct to cancer radiotherapy or chemotherapy [3,4]. Its use is based on the fact that tumor cells are more sensitive to temperature in the range of 42–45°C (which yields necrosis, coagulation, or carbonization) than normal tissue cells. This temperature range has become critical for cancer treatment due to damaging the cancerous cells without altering the healthy cells by selective heating (up to 45°C) and controlling heating rate and time

Reactive self-heating model of aluminum spherical nanoparticles

Aluminum-oxygen reaction is important in many highly energetic, high pressure generating systems. Recent experiments with nanostructured thermites suggest that oxidation of aluminum nanoparticles occurs in a few microseconds. Such rapid reaction cannot be explained by a conventional diffusion-based mechanism. We present a rapid oxidation model of a spherical aluminum nanoparticle, using Cabrera-Mott moving boundary mechanism, and taking self-heating into account. In our model, electric potential solves the nonlinear Poisson equation. In contrast with the Coulomb potential, a "double-layer" type solution for the potential and self-heating leads to enhanced oxidation rates. At maximal reaction temperature of 2000 C, our model predicts overall oxidation time scale in microseconds range, in agreement with experimental evidence.Comment: submitte

Modeling and Simulation of Janus-like Nanoparticles Formation by Solid-Gas Exothermic Reactions

Theoretical model for the simulation of synthesis of Janus-like particles (JP) consisting two different phases using the Carbon Combustion Synthesis of Oxides (CCSO) is presented. The model includes the variation of sample initial porosity, carbon concentration and oxygen flow rate used to predict the formation of JP features. The two temperature (2T) combustion model of chemically active submicron-dispersed mixture of two phases including ferroelectric and ferromagnetic was implemented and assessed by using the experimentally estimated activation energy of 112±3.3 kJ/mol and combustion temperature. The experimental values allowed to account the thermal and concentration expansion effect along with the dispersion by the slip-jump simulation for high Knudsen numbers. The model predicted that the smaller initial porosity of the combustion media creates higher formation rate of Janus-like particles. The simulation of slippage and jumps of the gas temperature allowed the scale-bridging between macro- and micro- structures

Simulation of the Elastic Properties of Reinforced Kevlar-Graphene Composites

The compressive strength of unidirectional fiber composites in the form of Kevlar yarn with a thin outer layer of graphene was investigated and modeled. Such fiber structure may be fabricated by using a strong chemical bond between Kevlar yarn and graphene sheets. Chemical functionalization of graphene and Kevlar may achieved by modification of appropriate surface-bound functional (e.g., carboxylic acid) groups on their surfaces. In this report we studied elastic response to unidirectional in-plane applied load with load peaks along the diameter. The 2D linear elasticity model predicts that significant strengthening occurs when graphene outer layer radius is about 4 % of kevlar yarn radius. The polymer chains of Kevlar are linked into locally planar structure by hydrogen bonds across the chains, with transversal strength considerably weaker than longitudinal one. This suggests that introducing outer enveloping layer of graphene, linked to polymer chains by strong chemical bonds may significantly strengthen Kevlar fiber with respect to transversal deformations

The behavior of nanothermite reaction based on Bi2O3/Al

We studied the impact of aluminum particle size and the thickness of surrounding alumina layer on the dynamic pressure discharge of nanothermite reactions in the Bi2O3/Al system. A pressure discharge from 9 to 13 MPa was generated using as-synthesized Bi2O3 nano-particles produced by combustion synthesis and Al nanoparticles with size from 3 μm to 100 nm. The maximum reaction temperature was measured to be ∼2700 °C. The estimated activation energy of the reaction was 45 kJ/mol. A very large (several orders of magnitude) difference existed between the rate of the pressure pulse release by nanothermite reactions and by thermite reactions with large aluminum particles. The maximum observed pressurization rate was 3200 GPa/s. The time needed to reach the peak pressure was 0.01 ms and 100 ms for aluminum particles with diameter of 100 nm and 70 microns, respectively. The discharge pressure was a monotonic decreasing function of the thickness of the surrounding alumina layer

Electric-Field Generated by the Combustion of Titanium in Nitrogen

A short temporal electrical impulse (duration of 30–150ms) was generated during the nitridation of mixtures of titanium and titanium nitride by a high temperature moving reaction front. The maximum voltage and current were generated in the combustion front region, in which the conversion of Ti to TiN was incomplete. The electric field (voltage up to 2V and current up to 60mA) decayed and vanished before the maximum combustion temperature was attained. The generation of an electric field during a rapid high-temperature nitridation is most probably due to the different diffusion velocities of charge carriers through the growing titanium nitride shell during the initial stage of the reaction. When the reactant mixture contained a high percentage of pure titanium (larger than 60wt%), partial melting led to irreproducibility in the amplitude and duration of the electrical signal

Electrical pulse formation during high temperature reaction between Ni and Al

An electric voltage pulse (duration of about 2ms) with an amplitude of up to 0.6V was generated during the reaction between nickel and aluminum powders by a high temperature moving reaction front. The electrical signal formed during the initial stages of the combustion was annihilated before the moving front attained its maximum temperature. The voltage amplitude and combustion temperature depended on the particle size of the reactants as well as the Al to Ni ratio in the reactant mixture, and their largest values were attained for a mixture containing 27–31.5wt% Al. The combustion temperature increased when smaller Al particles were used. The electric signals annihilated either due to the growth of the initially formed product layer and∕or as a result of the formation of a molten Al matrix as the reaction propagated. Oscillatory signals formed during unstable combustion in which the reaction front was perturbed. Unipolar and nonoscillating signals formed when the combustion front was planar. We conjecture that the electric field was generated by the different diffusion rates of charge carriers through a reaction generated thin exterior intermediate products shell of Al3Ni∕Al3Ni2

Diffuse Spectra Model of Photoluminescence in Carbon Quantum Dots

The attractive aspect of excitation related to fluorescence nature in carbon quantum dots (CQD) has guided to several assumptions correlated with clusters size distribution, shapes as well as presence of different emissive states. In this study, a dimer–excimer model of photoluminescence (PL) in CQD describing discrete multiple electronic states for the excitation-dependent emission is described. The functional dependence of the characteristic width of the diffuse spectra of PL on the size of a quantum dots are calculated. The effective width of PL spectrum can be tuned from 0.1 to 1 eV

Gravity Effect on Electrical Field Generation and Charge Carriers Transfer During Combustion Synthesis of Sulfides

The effect of gravity on the electric potential generated by the combustion synthesis of zinc sulfide is analyzed using the numerical simulation. Recent experimental studies on generation of electric voltage during combustion synthesis of zinc sulfide (ZnS) have revealed high voltage signals (4 V) with duration about 1 s, which are much higher than those produced by the gas–solid and solid–solid combustion reactions studied previously. These data have raised the question about mechanism of such a phenomenon. In our previous work we developed a novel (distributed) model describing the electric potential generation during combustion synthesis of sulfides (CSS) that didn\u27t count the effect of gravity. In this paper the simulations of heat - mass transfer, charge carriers motion, and voltage profiles taking into account the Earth gravity effect. The simulations confirms that the gravitation force strongly affects the emission of negatively charged sulfur ions as well as electrons and has a significant impact on the amplitude and temporal evolution of the combustion induced voltage. The voltage reduction up to four times has been observed numerically in the case when gravity acts in the direction coincident to that of the propagating combustion wave. Vice versa, the significant acceleration of the combustion and the voltage amplification due to the advection is simulated when gravity acts in the direction opposite to that of the propagating combustion wave

Screen-printing of ferrite magnetic nanoparticles produced by carbon combustion synthesis of oxides

The feasibility of screen-printing process of hard ferrite magnetic nanoparticles produced by carbon combustion synthesis of oxides (CCSO) is investigated. In CCSO, the exothermic oxidation of carbon generates a smolder thermal reaction wave that propagates through the solid reactant mixture converting it to the desired oxides. The complete conversion of hexaferrites occurs using reactant mixtures containing 11 wt. % of carbon. The BaFe12O19 and SrFe12O19 hexaferrites had hard magnetic properties with coercivity of 3 and 4.5 kOe, respectively. It was shown that the synthesized nanoparticles could be used to fabricate permanent magnet structures by consolidating them using screen-printing techniques