On the interplay between fluctuations and efficiency in a model economy with heterogeneous adaptive consumers

We discuss the stationary states of a model economy in which $N$ heterogeneous adaptive consumers purchase commodity bundles repeatedly from $P$ sellers. The system undergoes a transition from an inefficient to an efficient state as the number of consumers increases. In the latter phase, however, price fluctuations may be much larger than in the inefficient regime. Results from dynamical mean-field theory obtained for $N\to\infty$ compare fairly well with computer simulations.Comment: prepared for the proceedings of Fluctuations and Noise 200

Replica symmetry breaking in the minority game

We extend and complete recent work concerning the analytic solution of the minority game. Nash equilibria (NE) of the game have been found to be related to the ground states of a disordered hamiltonian with replica symmetry breaking (RSB), signalling the presence of a large number of them. Here we study the number of NE both analytically and numerically. We then analyze the stability of the recently-obtained replica-symmetric (RS) solution and, in the region where it becomes unstable, derive the solution within one-step RSB approximation. We are finally able to draw a detailed phase diagram of the model.Comment: Replaced with a revised versio

Rock falls impacting railway tracks. Detection analysis through an artificial intelligence camera prototype

During the last few years, several approaches have been proposed to improve early warning systems for managing geological risk due to landslides, where important infrastructures (such as railways, highways, pipelines, and aqueducts) are exposed elements. In this regard, an Artificial intelligence Camera Prototype (AiCP) for real-time monitoring has been integrated in a multisensor monitoring system devoted to rock fall detection. An abandoned limestone quarry was chosen at Acuto (central Italy) as test-site for verifying the reliability of the integratedmonitoring system. A portion of jointed rockmass, with dimensions suitable for optical monitoring, was instrumented by extensometers. One meter of railway track was used as a target for fallen blocks and a weather station was installed nearby. Main goals of the test were (i) evaluating the reliability of the AiCP and (ii) detecting rock blocks that reach the railway track by the AiCP. At this aim, several experiments were carried out by throwing rock blocks over the railway track. During these experiments, the AiCP detected the blocks and automatically transmitted an alarm signal

MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory

It has recently been suggested that the competition for a finite pool of microRNAs (miRNA) gives rise to effective interactions among their common targets (competing endogenous RNAs or ceRNAs) that could prove to be crucial for post-transcriptional regulation (PTR). We have studied a minimal model of PTR where the emergence and the nature of such interactions can be characterized in detail at steady state. Sensitivity analysis shows that binding free energies and repression mechanisms are the key ingredients for the cross-talk between ceRNAs to arise. Interactions emerge in specific ranges of repression values, can be symmetrical (one ceRNA influences another and vice-versa) or asymmetrical (one ceRNA influences another but not the reverse) and may be highly selective, while possibly limited by noise. In addition, we show that non-trivial correlations among ceRNAs can emerge in experimental readouts due to transcriptional fluctuations even in absence of miRNA-mediated cross-talk.Comment: 15 pages, 10 figures, to appear in Biophys

RNA-based regulation: dynamics and response to perturbations of competing RNAs

The observation that, through a titration mechanism, microRNAs (miRNAs) can act as mediators of effective interactions among their common targets (competing endogenous RNAs or ceRNAs) has brought forward the idea ('ceRNA hypothesis') that RNAs can regulate each other in extended 'cross-talk' networks. Such an ability might play a major role in post-transcriptional regulation (PTR) in shaping a cell's protein repertoire. Recent work focusing on the emergent properties of the cross-talk networks has emphasized the high flexibility and selectivity that may be achieved at stationarity. On the other hand, dynamical aspects, possibly crucial on the relevant time scales, are far less clear. We have carried out a dynamical study of the ceRNA hypothesis on a model of PTR. Sensitivity analysis shows that ceRNA cross-talk is dynamically extended, i.e. it may take place on time scales shorter than those required to achieve stationairity even in cases where no cross-talk occurs in the steady state, and is possibly amplified. Besides, in case of large, transfection-like perturbations the system may develop strongly non-linear, threshold response. Finally, we show that the ceRNA effect provides a very efficient way for a cell to achieve fast positive shifts in the level of a ceRNA when necessary. These results indicate that competition for miRNAs may indeed provide an elementary mechanism to achieve system-level regulatory effects on the transcriptome over physiologically relevant time scales.Comment: Main text: 10 pages, 13 figures. Supporting Text: 3 pages, 6 figure

Uniform sampling of steady states in metabolic networks: heterogeneous scales and rounding

The uniform sampling of convex polytopes is an interesting computational problem with many applications in inference from linear constraints, but the performances of sampling algorithms can be affected by ill-conditioning. This is the case of inferring the feasible steady states in models of metabolic networks, since they can show heterogeneous time scales . In this work we focus on rounding procedures based on building an ellipsoid that closely matches the sampling space, that can be used to define an efficient hit-and-run (HR) Markov Chain Monte Carlo. In this way the uniformity of the sampling of the convex space of interest is rigorously guaranteed, at odds with non markovian methods. We analyze and compare three rounding methods in order to sample the feasible steady states of metabolic networks of three models of growing size up to genomic scale. The first is based on principal component analysis (PCA), the second on linear programming (LP) and finally we employ the lovasz ellipsoid method (LEM). Our results show that a rounding procedure is mandatory for the application of the HR in these inference problem and suggest that a combination of LEM or LP with a subsequent PCA perform the best. We finally compare the distributions of the HR with that of two heuristics based on the Artificially Centered hit-and-run (ACHR), gpSampler and optGpSampler. They show a good agreement with the results of the HR for the small network, while on genome scale models present inconsistencies.Comment: Replacement with major revision

A working model on large-scale spatio-temporal organization of brain functioning and its implications for bipolar disorder

A working model on large-scale spatio-temporal organization of brain functioning and its implications for bipolar disorde

Investigating rock mass failure precursors using a multi-sensor monitoring system. Preliminary results from a test-site (Acuto, Italy)

In the last few years, several approaches and methods have been proposed to improve early warning systems for managing risks due to rapid slope failures where important infrastructures are the main exposed elements. To this aim, a multi-sensor monitoring system has been installed in an abandoned quarry at Acuto (central Italy) to realise a natural-scale test site for detecting rock-falls from a cliff slope. The installed multi-sensor monitoring system consists of: i) two weather stations; ii) optical cam (Smart Camera) connected to an Artificial Intelligence (AI) system; iii) stress- strain geotechnical system; iv) seismic monitoring device and nano-seismic array for detecting microseismic events on the cliff slope. The main objective of the experiment at this test site is to investigate precursors of rock mass failures by coupling remote and local sensors. The integrated monitoring system is devoted to record strain rates of rock mass joints, capturing their variations as an effect of forcing actions, which are the temperature, the rainfalls and the wind velocity and direction. The preliminary tests demonstrate that the data analysis methods allowed the identification of external destabilizing actions responsible for strain effects on rock joints. More in particular, it was observed that the temperature variations play a significant role for detectable strains of rock mass joints. The preliminary results obtained so far encourage further experiments

Detection of nanoseismic events related to slope instabilities in the quarry district of Coreno Ausonio (Italy)

Le cave per l’estrazione di materiale roccioso rappresentano contesti in cui possono aver luogo eventi di instabilità gravitativa causati dalle continue sollecitazioni cui sono soggette le pareti produttive, principalmente connesse alle vibrazioni dovute alle esplosioni necessarie alle operazioni di disgaggio. La necessità di gestione del rischio da frana per la salvaguardia del personale impegnato nell’attività estrattiva ha portato, nel tempo, alla richiesta di attivare sistemi di monitoraggio nelle aree di coltivazione mineraria e di cava. Nel presente lavoro il monitoraggio nanosismometrico, una tecnica di geofisica passiva recentemente sviluppata per le indagini di microsismicità, è stato impiegato nel distretto di cave a cielo aperto di Coreno Ausonio (in provincia di Frosinone). Il monitoraggio nanosismometrico consente l’individuazione e la localizzazione di deboli eventi sismici, fino a magnitudo locale (ML) nell’ordine di -3, attraverso l’impiego di quattro sensori sismometrici disposti secondo una specifica geometria di array detta SNS (Seismic Navigation System). Dopo aver individuato una cava in cui erano programmate esplosioni per la volata delle pareti in roccia, nel corso del 2013 sono state organizzate 3 campagne di acquisizione durante tre giornate, pianificate in modo da monitorare l’area in un periodo compreso da qualche ora prima dell’esplosione alle 24 ore successive. Su una parete della cava non più produttiva è stato effettuato un rilevamento geologico-tecnico che ha permesso di individuare 4 principali sistemi di discontinuità e caratterizzarli in termini di giacitura, resistenza, rugosità, apertura, spaziatura e condizioni idrauliche secondo gli standard ISRM (1978). L’analisi di stabilità della parete in esame, tenuto conto della sua orientazione, ha restituito una scarsa propensione ad eventi di instabilità. Analizzando mediante il software NanoseismicSuite i dati sismometrici acquisiti è stato possibile ottenere i “supersonogrammi”, ovvero particolari spettrogrammi auto-adattanti alle variazioni del rumore sismico di fondo, dai quali sono state definite alcune caratteristiche specifiche di forma d’onda per diverse tipologie di eventi. In base ai supersonogrammi, è stato possibile individuare e localizzare 15 esplosioni, di cui 3 provenienti dalla cava di riferimento e 12 da cave adiacenti del distretto, e 27 deboli eventi di instabilità gravitativa, distinti in 23 eventi di collasso e 4 rotture legate alle fratturazione dell’ammasso roccioso. Le 3 esplosioni avvenute nella cava di riferimento, e quindi aventi coordinate di origine nota, sono state utilizzate per calibrare il modello di sottosuolo, successivamente impiegato per localizzare gli altri eventi registrati. Le rotture sono risultate originate in diverse zone del distretto estrattivo, mentre gli eventi di collasso sono stati localizzati in una specifica area e risultano essere avvenuti prevalentemente in un limitato intervallo di tempo a seguito delle 9 esplosioni registrate nella campagna del 26-27 luglio 2013. Non è stato possibile, invece, individuare eventi riconducibili ad instabilità negli orari di attività di cava a causa dell’elevato livello di rumore apportato dagli strumenti per l’estrazione e la lavorazione del materiale roccioso. Si è escluso che gli eventi di collasso fossero riconducibili direttamente all’attività di estrazione sia perché registrati al di fuori dell’orario di lavorazione delle cave sia perché, analizzando l’intera registrazione per intervalli orari, le frequenze tipiche dei macchinari di lavorazione non sono risultate energizzante. La zona di origine è risultata essere un’area nella quale sono stati rinvenuti detrito sciolto costituito da blocchi eterometrici ed una parete non in coltivazione con medesime caratteristiche delle discontinuità rispetto alla parete sulla quale era stato effettuato il rilevamento geologico-tecnico, ma con diversa orientazione. In definitiva, la fase di sperimentazione ha restituito dei risultati di indubbio interesse consentendo di mettere in evidenza alcune limitazioni del monitoraggio nanosismometrico nel contesto preso in esame, in particolare legate all’eccessiva rumorosità registrata nelle ore di attività di cava. La tecnica appare, comunque, un utile strumento di monitoraggio per i fenomeni gravitativi di debole intensità, in grado di contribuire alla gestione del rischio da frana in aree ad elevata attività antropica ed in ambienti naturalmente predisposti ad instabilità gravitative che possono interessare pareti in roccia.Nanoseismic monitoring is a passive geophysical technique used to identify and locate weak seismic events (down to local magnitudes, ML, around -3). This technique was applied in the open-pit quarry district of Coreno Ausonio (central Italy) to detect possible gravity-induced slope instabilities resulting from quarry rock blasting. After identifying an active quarry, an engineering-geological survey was carried out to characterise the jointed rock mass on an abandoned wall in front of the quarry. Four main joint sets were surveyed and their geometric and mechanical properties were measured in order to carry out stability analyses that evidenced scarce proneness to failure of the investigated wall. The analysis of seismic records obtained during three monitoring surveys, performed through the NanoseismicSuite software, made it possible to detect and characterise 15 blasts, of which 3 from the reference quarry and 12 from nearby quarries within the district, as well as 27 weak slope instability events (23 collapses and 4 failures). While failures originated from different areas of the quarry district, collapses occurred in a site characterised by an abandoned quarry having a wall more prone to gravity-induced instabilities than the one previously characterised