From Prospero to Peter Palmer : Appropriation of a Shakespearian Character in a Contemporary Short-Story Rewriting of The Tempest

As far as its afterlife during centuries is concerned, several transcodifications have been performed on The  Tempest to make it go beyond the textual and stage limits prescribed by its hypotext, as if it had its own  border to cross. This paper tries to focus on a peculiar transcodification, a contemporary short-story, “Rough  Magic”, included in the volume Shakespeare Stories edited in 1982 by Giles Gordon (1940-2003), and  written by the British journalist, literary critic and novelist David Hughes (1930-2005). Starting from a short  overview both of the cultural reception of the play and of its adaptations, this paper aims at interpreting the  story through a double perspective. First, by tracing the clues of a continuing fascination of imperialist will  to power nowadays and its (metaphorical?) colonialist implications through a contrapuntal reading. Second,  it attempts at exploring and decoding the complex multi-layered structure of dichotomies concerning the  key-concept of borders which underlie the short-story narrative strategies, given the idea that the colonizing  process performed by the protagonist can be seen as a multiple sequence of crossing borders.As far as its afterlife during centuries is concerned, several transcodifications have been performed on The  Tempest to make it go beyond the textual and stage limits prescribed by its hypotext, as if it had its own  border to cross. This paper tries to focus on a peculiar transcodification, a contemporary short-story, “Rough  Magic”, included in the volume Shakespeare Stories edited in 1982 by Giles Gordon (1940-2003), and  written by the British journalist, literary critic and novelist David Hughes (1930-2005). Starting from a short  overview both of the cultural reception of the play and of its adaptations, this paper aims at interpreting the  story through a double perspective. First, by tracing the clues of a continuing fascination of imperialist will  to power nowadays and its (metaphorical?) colonialist implications through a contrapuntal reading. Second,  it attempts at exploring and decoding the complex multi-layered structure of dichotomies concerning the  key-concept of borders which underlie the short-story narrative strategies, given the idea that the colonizing  process performed by the protagonist can be seen as a multiple sequence of crossing borders

The cocktail party effect. An inclusive vision of conversational interactions

Studying the behaviour of disabled users can provide data for designing inclusive technologies for everyone. The focus of this paper is the field of inclusive design in conversational interaction.S..

Newsworthiness and Emotivity

In 1915 the echo of the Ottoman massacres of the Christian minorities living within the borders of the Empire reached the international press at once. The Times functioned as an English-language cross-cultural referential platform for its international readership, and regularly published letters to the editor reporting on the political and humanitarian events involving the Armenians. Those letters to the editor were written in English by notable authors from different national backgrounds and political appointments, including also Armenian notables and delegates. A corpus of letters to the editor of The Times was collected for the purpose of this study and examined through a corpus-driven and a corpus-assisted approach. This article focuses on a quantitative and qualitative analysis of recurring language of evaluation related to discursive news value analysis, with a specific focus on how the parameter of “emotivity” is expressed through the language used in the letters. This study attempts to explain the linguistic strategies through which a cross-cultural intersubjective connection with the readership of The Times was created, and it also attempts to clarify the textual strategies implemented in the letters to the editor of The Times to keep the Armenian events newsworthy

Evaluation of the relationships between computed tomography features, pathological findings, and rrognostic risk assessment in gastrointestinal stromal tumors

Objectives The aim of this study was to correlate computed tomography (CT) findings with pathology in gastrointestinal stromal tumors (GISTs). Methods A retrospective evaluation of CT images of 44 patients with GISTs was performed. Computed tomography findings analyzed were location, size, margins, degree and pattern of contrast enhancement, angiogenesis, necrosis, signs of invasion, peritoneal effusion, peritoneal implants, surface ulceration, and calcifications. Associations between CT features and mitotic rate, Miettinen classes of risk, lesions size, and among CT features were investigated. χ 2 Test and Fisher test were performed. Results Mitotic rate was associated with margins (P = 0.016) and with adjacent organ invasion (P = 0.043). Pattern of contrast enhancement (P = 0.002), angiogenesis (P = 0.006), necrosis (P = 0.006), invasion of adjacent organs (P = 0.011), and margins (P = 0.006) were associated with classes of risk. Several associations (P < 0.05) between lesion size and CT features and among all the investigated CT features were found. Conclusions Computed tomography features could reflect GIST biology being associated with the mitotic rate and with classes of risk

Granulocytic myeloid-derived suppressor cells increased in early phases of primary HIV infection depending on TRAIL plasma level

Background It has been demonstrated that Myeloid Derived Suppressor Cells (MDSC) are expanded in HIV-1 infected individuals and correlated with disease progression. The phase of HIV infection during which MDSC expansion occurs, and the mechanisms that regulate this expansion remain to be established. In this study we evaluated the frequency of MDSC in patients during primary HIV infection, and factors involved in MDSC control. Methods Patients with primary (PHI) and chronic (CHI) HIV infection were enrolled. PHI staging was performed according to Fiebig classification, and circulating MDSC frequency and function were evaluated by flow cytometry. Cytokine levels were evaluated by Luminex technology. Results We found that granulocytic MDSC (Gr-MDSC) frequency was higher in PHI compared to healthy donors, but lower than CHI. Interestingly, Gr-MDSC expansion was observed in the early phases of HIV infection (Fiebig II/III), but it was not associated to HIV viral load and CD4 T cell count. Interestingly, in PHI Gr-MDSC frequency was inversely correlated with plasmatic level of TRAIL, while a direct correlation was observed in CHI. Further, lower level of GMCSF was observed in PHI compared with CHI. In vitro experiments demonstrated that, differently from CHI, recombinant TRAIL induced apoptosis of Gr-MDSC from PHI, can effect that can be abrogated by GM-CSF. Conclusion We found that Gr-MDSC are expanded early during primary HIV infection and may be regulated by TRAIL and GM-CSF levels. These findings shed light on the fine mechanisms regulating the immune system during HIV infection, and open new perspectives for immune-based strategies

Lung MRI as a Possible Alternative to CT Scan for Patients With Primary Immune Deficiencies and Increased Radiosensitivity

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Transcriptional Profiling of Rat Prefrontal Cortex after Acute Inescapable Footshock Stress

Stress is a primary risk factor for psychiatric disorders such as Major Depressive Disorder (MDD) and Post Traumatic Stress Disorder (PTSD). The response to stress involves the regulation of transcriptional programs, which is supposed to play a role in coping with stress. To evaluate transcriptional processes implemented after exposure to unavoidable traumatic stress, we applied microarray expression analysis to the PFC of rats exposed to acute footshock (FS) stress that were sacrificed immediately after the 40 min session or 2 h or 24 h after. While no substantial changes were observed at the single gene level immediately after the stress session, gene set enrichment analysis showed alterations in neuronal pathways associated with glia development, glia-neuron networking, and synaptic function. Furthermore, we found alterations in the expression of gene sets regulated by specific transcription factors that could represent master regulators of the acute stress response. Of note, these pathways and transcriptional programs are activated during the early stress response (immediately after FS) and are already turned off after 2 h-while at 24 h, the transcriptional profile is largely unaffected. Overall, our analysis provided a transcriptional landscape of the early changes triggered by acute unavoidable FS stress in the PFC of rats, suggesting that the transcriptional wave is fast and mild, but probably enough to activate a cellular response to acute stress

Effectiveness of Immunoglobulin Replacement Therapy on Clinical Outcome in Patients with Primary Antibody Deficiencies: Results from a Multicenter Prospective Cohort Study

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