Factors affecting brownfield regeneration in post-socialist space: the case of the Czech Republic

Using an example of the Czech Republic, this explorative study attempts to answer the question of what factors have a significant influence on a successful regeneration of brownfields in a post-socialistic space. The study is based on a comparative analysis of two data files – the database of existing brownfields provided by the national CzechInvest agency, and the database of successfully regenerated brownfields compiled by the authors themselves. The paper consists of three interrelated parts, the first one dealing with an analysis of the structure of regenerated brownfields, the second one confronting this with the structure of the existing brownfields by means of a comparative analysis, and the third one analyzing the factors of brownfield regeneration. The main types of functional transformation of space were identified and the factors that appeared to be significant determinants of brownfields regeneration were classified as the result

Where AD plants wildly grow: the spatio-temporal diffusion of agricultural biogas production in the Czech Republic

There is fundamental agreement about the environmental benefits of renewable energy technologies, but unintended consequences arising from their deployment are frequent sources of conflicts. The Czech Republic has committed itself to supply 13.5% of its electricity consumption from renewable sources by 2020. High state incentives for renewable energies have been provided to achieve this target, however critical questions can be asked about the appropriateness of the design of the supporting frameworks which caused a boom in photo-voltaic (PV) installations on agricultural land, as well as a boom in the installation of agricultural anaerobic digestion (AD) plants fuelled by dedicated energy crops. This paper analyses the diffusion of agricultural AD plants in the Czech Republic, focusing especially on locational characteristics in relation to the quality of agricultural land, agricultural and population census data. Statistical analysis of those spatial datasets show that agricultural AD plants are mostly located in less favourable agricultural areas, in regions having recently experienced a reduction in cattle breeding, and in regions with significant increases of sowing areas of green maize. These findings suggests shortcomings in the supporting policy for AD plants in the Czech Republic, resulting in unintended environmental consequences, and missed opportunities to enhance energy self-sufficiency and resilience in the countryside

Timbre brownfield prioritization tool to support effective brownfield regeneration.

In the last decade, the regeneration of derelict or underused sites, fully or partly located in urban areas (or so called “brownfields”), has become more common, since free developable land (or so called “greenfields”) has more and more become a scare and, hence, more expensive resource, especially in densely populated areas. Although the regeneration of brownfield sites can offer development potentials, the complexity of these sites requires considerable efforts to successfully complete their revitalization projects and the proper selection of promising sites is a pre-requisite to efficiently allocate the limited financial resources. The identification and analysis of success factors for brownfield sites regeneration can support investors and decision makers in selecting those sites which are the most advantageous for successful regeneration. The objective of this paper is to present the Timbre Brownfield Prioritization Tool (TBPT), developed as a web-based solution to assist stakeholders responsible for wider territories or clusters of brownfield sites (portfolios) to identify which brownfield sites should be preferably considered for redevelopment or further investigation. The prioritization approach is based on a set of success factors properly identified through a systematic stakeholder engagement procedure. Within the TBPT these success factors are integrated by means of a Multi Criteria Decision Analysis (MCDA) methodology, which includes stakeholders' requalification objectives and perspectives related to the brownfield regeneration process and takes into account the three pillars of sustainability (economic, social and environmental dimensions). The tool has been applied to the South Moravia case study (Czech Republic), considering two different requalification objectives identified by local stakeholders, namely the selection of suitable locations for the development of a shopping centre and a solar power plant, respectively. The application of the TBPT to the case study showed that it is flexible and easy to adapt to different local contexts, allowing the assessors to introduce locally relevant parameters identified according to their expertise and considering the availability of local data

GPR, a ground‐penetrating radar for the Netlander mission

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95485/1/jgre1563.pd

Good governance as a strategic choice in brownfield regeneration: Regional dynamics from the Czech Republic

The application of principles of good governance in brownfield regeneration, for instance through improved transparency and participation of various groups of stakeholders, varies between regions and cities. In this article, we approach good governance as a strategic response of actors in the struggle for creating development opportunities on brownfield land. Good governance has been mostly seen as a normative consideration, but it is not clear why regions with lower development prospects would employ it more than better developed regions, as it recently happened in the Czech Republic. We assume that the public administration at the regional and municipal level plays an active role in divising strategies to attract investors for brownfield redevelopment. This process brings public administrations in interaction with each other and with investors, regulators and civil society groups within a society-wide brownfield redevelopment field. This field is an arena where all these different actors struggle for redeveloping their brownfield land. Regional and municipal administrations from developed regions stand to benefit from their higher economic growth potential and hence have a dominant position within the field. We identify the latter as the incumbents or “power-holders” of the national brownfield regeneration field. Less developed regions have lower attractiveness for brownfield redevelopment, which places them in a subordinate position in the field. They are so-called challengers that are likely to favor alternative strategies for their brownfields, going beyond mere economic attractiveness. By comparing differently developed regions and regional capitals in the Czech Republic, we show how some challengers use good governance, such as responsiveness, participation and transparency, as an alternative strategy to attract investors despite their economic predicament. For regional capitals, however, good governance is practiced both by highly developed and less developed cities. We draw evidence from interviews with key stakeholders and socio-economic data at the regional and municipal level in the Czech Republic. In the conclusion, we show some of the identified limitations in good governace, such as obstacles to participation, responsiveness or transparency, and how they can be recognized and overcome

DJ-1 contributes to adipogenesis and obesity-induced inflammation

Adipose tissue functions as an endocrine organ, and the development of systemic inflammation in adipose tissue is closely associated with metabolic diseases, such as obesity and insulin resistance. Accordingly, the fine regulation of the inflammatory response caused by obesity has therapeutic potential for the treatment of metabolic syndrome. In this study, we analyzed the role of DJ-1 (PARK7) in adipogenesis and inflammation related to obesity in vitro and in vivo. Many intracellular functions of DJ-1, including oxidative stress regulation, are known. However, the possibility of DJ-1 involvement in metabolic disease is largely unknown. Our results suggest that DJ-1 deficiency results in reduced adipogenesis and the down-regulation of pro-inflammatory cytokines in vitro. Furthermore, DJ-1-deficient mice show a low-level inflammatory response in the high-fat diet-induced obesity model. These results indicate previously unknown functions of DJ-1 in metabolism and therefore suggest that precise regulation of DJ-1 in adipose tissue might have a therapeutic advantage for metabolic disease treatment.open0

Limited Trafficking of a Neurotropic Virus Through Inefficient Retrograde Axonal Transport and the Type I Interferon Response

Poliovirus is an enteric virus that rarely invades the human central nervous system (CNS). To identify barriers limiting poliovirus spread from the periphery to CNS, we monitored trafficking of 10 marked viruses. After oral inoculation of susceptible mice, poliovirus was present in peripheral neurons, including vagus and sciatic nerves. To model viral trafficking in peripheral neurons, we intramuscularly injected mice with poliovirus, which follows a muscle–sciatic nerve–spinal cord–brain route. Only 20% of the poliovirus population successfully moved from muscle to brain, and three barriers limiting viral trafficking were identified. First, using light-sensitive viruses, we found limited viral replication in peripheral neurons. Second, retrograde axonal transport of poliovirus in peripheral neurons was inefficient; however, the efficiency was increased upon muscle damage, which also increased the transport efficiency of a non-viral neural tracer, wheat germ agglutinin. Third, using susceptible interferon (IFN) α/β receptor knockout mice, we demonstrated that the IFN response limited viral movement from the periphery to the brain. Surprisingly, the retrograde axonal transport barrier was equivalent in strength to the IFN barrier. Illustrating the importance of barriers created by the IFN response and inefficient axonal transport, IFN α/β receptor knockout mice with muscle damage permitted 80% of the viral population to access the brain, and succumbed to disease three times faster than mice with intact barriers. These results suggest that multiple separate barriers limit poliovirus trafficking from peripheral neurons to the CNS, possibly explaining the rare incidence of paralytic poliomyelitis. This study identifies inefficient axonal transport as a substantial barrier to poliovirus trafficking in peripheral neurons, which may limit CNS access for other viruses

Chronic Methamphetamine Administration Causes Differential Regulation of Transcription Factors in the Rat Midbrain

Methamphetamine (METH) is an addictive and neurotoxic psychostimulant widely abused in the USA and throughout the world. When administered in large doses, METH can cause depletion of striatal dopamine terminals, with preservation of midbrain dopaminergic neurons. Because alterations in the expression of transcription factors that regulate the development of dopaminergic neurons might be involved in protecting these neurons after toxic insults, we tested the possibility that their expression might be affected by toxic doses of METH in the adult brain. Male Sprague-Dawley rats pretreated with saline or increasing doses of METH were challenged with toxic doses of the drug and euthanized two weeks later. Animals that received toxic METH challenges showed decreases in dopamine levels and reductions in tyrosine hydroxylase protein concentration in the striatum. METH pretreatment protected against loss of striatal dopamine and tyrosine hydroxylase. In contrast, METH challenges caused decreases in dopamine transporters in both saline- and METH-pretreated animals. Interestingly, METH challenges elicited increases in dopamine transporter mRNA levels in the midbrain in the presence but not in the absence of METH pretreatment. Moreover, toxic METH doses caused decreases in the expression of the dopamine developmental factors, Shh, Lmx1b, and Nurr1, but not in the levels of Otx2 and Pitx3, in saline-pretreated rats. METH pretreatment followed by METH challenges also decreased Nurr1 but increased Otx2 and Pitx3 expression in the midbrain. These findings suggest that, in adult animals, toxic doses of METH can differentially influence the expression of transcription factors involved in the developmental regulation of dopamine neurons. The combined increases in Otx2 and Pitx3 expression after METH preconditioning might represent, in part, some of the mechanisms that served to protect against METH-induced striatal dopamine depletion observed after METH preconditioning